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COVID-19 pandemic decreased the ophthalmic outpatient numbers and altered the diagnosis distribution in a community hospital in Taiwan: An observational study
by Chu-Yu Yen, I-Mo Fang, Huei-Fen Tang, Hsin-Jui Lee, Shang-Hsien Yang The aim of this study was to determine the effect of Coronavirus disease 2019 (COVID-19) pandemic on ophthalmic outpatient numbers and ophthalmic diagnosis distribution in a community hospital (Taipei City Hospital Zhongxiao Branch) in Taiwan. The COVID-19 pandemic period in Taiwan was defined as May 1 to July 31, 2021. Demographic data, including age, gender, and top 10 diagnoses from ophthalmic outpatients during this period, were collected. A corresponding control group from the same time in 2020 was also collected. The distribution of different di...
Source: PLoS One - March 8, 2022 Category: Biomedical Science Authors: Chu-Yu Yen Source Type: research

Central nervous system as a target of novel coronavirus infections: Potential routes of entry and pathogenic mechanisms
J Biosci. 2021;46:106.ABSTRACTSince the COVID-19 pandemic started in December 2019, there have been several reports of patients succumbing to neurological complications. Early reports were suggestive of a possibility, while by early 2020 it was clearly evident that although SARS-CoV-2 primarily attacks the respiratory system, the brain is one of the most affected organs post-recovery. Although it may be premature to comment on the long-term effects of COVID-19 in brain, some reliable predictions can be made based on the data currently available. Further, exploring the CNS connections of SARS-CoV-2 is of keen interest for n...
Source: Journal of Biosciences - November 29, 2021 Category: Biomedical Science Authors: Sapana Sharma Harsha Jagadeesh Ambrish Saxena Harshini Chakravarthy Vasudharani Devanathan Source Type: research

Clinical characterization and therapeutic targets of vitamin A in patients with hepatocholangiocarcinoma and coronavirus disease
Aging (Albany NY). 2021 Jun 27;13. doi: 10.18632/aging.203220. Online ahead of print.ABSTRACTRecent reports indicate that patients with hepatocholangiocarcinoma (CHOL) have a higher morbidity and mortality rate for coronavirus disease (COVID-19). Anti-CHOL/COVID-19 medicines are inexistent. Vitamin A (VA) refers to a potent nutrient with anti-cytotoxic and anti-inflammatory actions. Therefore, this study aimed to determine the potential functions and molecular mechanisms of VA as a potential treatment for patients with both CHOL and COVID-19 (CHOL/COVID-19). The transcriptome data of CHOL patients were obtained from the Ca...
Source: Aging - June 28, 2021 Category: Biomedical Science Authors: Xiao Liang Rui Zhou Yu Li Lu Yang Min Su Keng Po Lai Source Type: research

Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina?
ConclusionsIn this study, no significant level of SARS-CoV-2-RNA was detected in the human retinal and vitreous fluid samples of deceased COVID-19 patients. Histopathological examinations confirmed no morphological sign of damage to retinal vasculature or tissues. Further studies are needed to confirm or refute the results.
Source: PLoS One - May 13, 2021 Category: Biomedical Science Authors: Tarek Bayyoud Source Type: research

Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19.
In this study, bioinformatics analysis and computation assays using a network pharmacology method were conducted to explore and uncover the therapeutic targets and mechanisms of VA for treating COVID-19. We identified candidate targets, pharmacological functions, and therapeutic pathways of VA against SARS-CoV-2. Bioinformatics findings indicate that the mechanisms of action of VA against SARS-CoV-2 include enrichment of immunoreaction, inhibition of inflammatory reaction, and biological processes related to reactive oxygen species. Furthermore, seven core targets of VA against COVID-19, including MAPK1, IL10, EGFR, ICAM1,...
Source: Aging - August 14, 2020 Category: Biomedical Science Authors: Li R, Wu K, Li Y, Liang X, Tse WKF, Yang L, Lai KP Tags: Aging (Albany NY) Source Type: research

COVID-19 pandemic from an ophthalmology point of view.
Abstract Coronavirus disease 2019 (COVID-19) is caused by a highly contagious RNA virus termed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ophthalmologists are at high-risk due to their proximity and short working distance at the time of slit-lamp examination. Eye care professionals can be caught unaware because conjunctivitis may be one of the first signs of COVID-19 at presentation, even precluding the emergence of additional symptoms such as dry cough and anosmia. Breath and eye shields as well as N95 masks, should be worn while examining patients with fever, breathlessness, or any history ...
Source: The Indian Journal of Medical Research - April 30, 2020 Category: Biomedical Science Authors: Gupta PC, Kumar MP, Ram J Tags: Indian J Med Res Source Type: research