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Viruses, Vol. 15, Pages 1933: Unraveling the Dynamics of Omicron (BA.1, BA.2, and BA.5) Waves and Emergence of the Deltacton Variant: Genomic Epidemiology of the SARS-CoV-2 Epidemic in Cyprus (Oct 2021 & ndash;Oct 2022)
This study offers a comprehensive assessment spanning genetic, phylogenetic, phylodynamic, and phylogeographic dimensions, focused on the trajectory of the SARS-CoV-2 epidemic in Cyprus. Based on a dataset comprising 4700 viral genomic sequences obtained from affected individuals between October 2021 and October 2022, our analysis is presented. Over this timeframe, a total of 167 distinct lineages and sublineages emerged, including variants such as Delta and Omicron (1, 2, and 5). Notably, during the fifth wave of infections, Omicron subvariants 1 and 2 gained prominence, followed by the ascendancy of Omicron 5 in the subs...
Source: Viruses - September 15, 2023 Category: Virology Authors: Andreas C. Chrysostomou Bram Vrancken Christos Haralambous Maria Alexandrou Ioanna Gregoriou Marios Ioannides Costakis Ioannou Olga Kalakouta Christos Karagiannis Markella Marcou Christina Masia Michail Mendris Panagiotis Papastergiou Philippos C. Patsali Tags: Article Source Type: research

Genomic epidemiology of SARS-CoV-2 variants in South Korea between January 2020 and February 2023
Virology. 2023 Aug 26;587:109869. doi: 10.1016/j.virol.2023.109869. Online ahead of print.ABSTRACTThe Korea Disease Control and Prevention Agency (KDCA) has been conducting national genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). To monitor and characterize circulating SARS-CoV-2 variants in South Korea, 102,873 oropharyngeal/nasopharyngeal swab samples collected from patients with confirmed COVID-19 were sequenced, assigned lineages, and phylogenetically analyzed. Each wave followed a pattern of variants emerging first abroad and then spreading domestically. In 2020, B.41 lineage led ...
Source: Virology - September 6, 2023 Category: Virology Authors: Il-Hwan Kim Jin Sun No Jeong-Ah Kim Ae Kyung Park HyeokJin Lee Jeong-Min Kim Nam-Joo Lee Chi-Kyeong Kim Chae Young Lee SangHee Woo Jaehee Lee JeeEun Rhee Eun-Jin Kim Source Type: research

Vaccine effectiveness in symptom and viral load mitigation in COVID-19 breakthrough infections in South Korea
by Jieun Jang, Hyopin Jeong, Bong-Hwa Kim, Sura An, Hye-Ryun Yang, Sunjoo Kim ObjectivesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine effectiveness in coronavirus disease (COVID-19) patients with breakthrough infections has not been established in South Korea. To address this, we assessed the impact of vaccination on symptom occurrence and viral load. MethodsWe performed a retrospective cohort study of 9,030 COVID-19 patients enrolled between February and November 2021. The impact of vaccination on the incidence of symptoms and viral load as indicated by cycle threshold (Ct) values ofRdRp andE genes ...
Source: PLoS One - August 16, 2023 Category: Biomedical Science Authors: Jieun Jang Source Type: research

A Model-Based Cost-Effectiveness Analysis of Long-Acting Monoclonal Antibody (Tixagevimab and Cilgavimab: Evusheld) Preventive Treatment for High-Risk Populations Against SARS-CoV-2 in Korea
CONCLUSION: As the COVID-19 variants and risk group-specific durable efficacy, toxicity (and/or resistance) and optimal dosing of Evusheld remain uncertain, better empirical estimates to inform these values in different epidemiological contexts are needed. These results may help decision-makers prioritize resources toward more equitable and effective COVID-19 control efforts.PMID:37582500 | PMC:PMC10427216 | DOI:10.3346/jkms.2023.38.e250
Source: J Korean Med Sci - August 15, 2023 Category: General Medicine Authors: Youngji Jo Sun Bean Kim Jaehun Jung Source Type: research

Change in Severity and Clinical Manifestation of MIS-C Over SARS-CoV-2 Variant Outbreaks in Korea
CONCLUSION: Omicron period were associated with less severe clinical manifestation compared to pre-delta and delta periods. Although incidence rate of MIS-C was lower for the omicron period than pre-delta and delta periods, number of patients reported with MIS-C may pose a substantial clinical burden.PMID:37527908 | DOI:10.3346/jkms.2023.38.e225
Source: J Korean Med Sci - August 1, 2023 Category: General Medicine Authors: Young June Choe Eun Hwa Choi Jong Woon Choi Byung Wook Eun Lucy Youngmin Eun Yae-Jean Kim Yeo Hyang Kim Young A Kim Yun-Kyung Kim Ji Hee Kwak Hyukmin Lee June Dong Park Yeon Haw Jung Jin Gwack Sangwon Lee MIS-C Surveillance Group Source Type: research