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Advances in the surgical treatment of liver cancer
Biosci Trends. 2022 Jun 23. doi: 10.5582/bst.2022.01245. Online ahead of print.ABSTRACTLiver resection is the standard curative treatment for liver cancer. Advances in surgical techniques over the last 30 years, including the preoperative assessment of the future liver remnant, have improved the safety of liver resection. In addition, advances in nonsurgical multidisciplinary treatment have increased the opportunities for tumor downstaging. Consequently, the indications for resection of more advanced liver cancer have expanded. Laparoscopic and robot-assisted liver resections have also gradually become more widespread. The...
Source: BioScience Trends - June 22, 2022 Category: Biomedical Science Authors: Harufumi Maki Kiyoshi Hasegawa Source Type: research

Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients
This study reveals that COVID-19 and HCC are closely linked at the molecular level and proposes dr ugs that may play an important role in HCC patients with COVID-19. More importantly, according to the results of our research, two critical drugs, Ilomastat and Palmatine, may be effective for HCC patients with COVID-19, which provides clinicians with a novel therapeutic idea when facing possible co mplications in HCC patients with COVID-19.
Source: PLoS One - May 31, 2022 Category: Biomedical Science Authors: Luhong Wang Source Type: research

Clinical Effect of Hepatitis B Virus on COVID-19 Infected Patients: A Nationwide Population-Based Study Using the Health Insurance Review & amp;amp; Assessment Service Database
CONCLUSION: COVID-19-infected patients with HBV infections showed worse clinical courses than non-HBV-infected COVID-19 patients. However, after adjustment, chronic HBV infection itself does not seem to affect the clinical outcomes in COVID-19 patients.PMID:35075828 | PMC:PMC8787805 | DOI:10.3346/jkms.2022.37.e29
Source: Journal of Korean Medical Science - January 25, 2022 Category: Biomedical Science Authors: Jung Wan Choe Young Kul Jung Hyung Joon Yim Gi Hyeon Seo Source Type: research

< em > In silico < /em > analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients
Aging (Albany NY). 2021 Jun 24;13. doi: 10.18632/aging.203159. Online ahead of print.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), and is highly contagious and pathogenic. TMPRSS2 and Neuropilin-1, the key components that facilitate SARS-CoV-2 infection, are potential targets for treatment of COVID-19. Here we performed a comprehensive analysis on NRP1 and TMPRSS2 in lung to provide information for treating comorbidity of COVID-19 with lung cancer. NRP1 is widely expressed across all the human tissues while TMPRSS2 is expressed in a restricted pattern. ...
Source: Aging - June 25, 2021 Category: Biomedical Science Authors: Song Hu Zheyu Hu Jiajia Qin Chuwen Lin Xuan Jiang Source Type: research

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