Primitive neuroectodermal tumors of the ovary: a multidecade review of the scientific literature
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):5-12. doi: 10.47162/RJME.65.1.01.ABSTRACTPrimitive neuroectodermal tumor (PNET) is a general term used in scientific literature for a heterogeneous group of small round-cell malignant tumors primarily arising from neural crest cells. These are extremely aggressive neoplasms which usually occur within soft tissue or bone of young adults. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare, with only few case reports in scientific literature. Due to being so exceedingly rare, PNETs are frequently misdiagnosed and there are no standard therapeutic guidelin...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Tiberiu Augustin Georgescu Antonia Carmen Georgescu Andrei Dennis Voichi ţoiu Drago ş Creţoiu Nicolae Suciu Adriana Irina Ciuvic ă Source Type: research
Neurobiological mechanisms and therapeutic impact of electroconvulsive therapy (ECT)
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):13-17. doi: 10.47162/RJME.65.1.02.ABSTRACTElectroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefrontal region of the brain and spreads to the cortex and subcortex, including the diencephalic structures. This is achieved by creating a transcranial electric field and synchronously depolarizing neuronal membranes. The mechanisms of action of EC...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Ana Maria Cojocaru Antonia Ioana Vasile Simona Corina Trifu Source Type: research
Primitive neuroectodermal tumors of the ovary: a multidecade review of the scientific literature
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):5-12. doi: 10.47162/RJME.65.1.01.ABSTRACTPrimitive neuroectodermal tumor (PNET) is a general term used in scientific literature for a heterogeneous group of small round-cell malignant tumors primarily arising from neural crest cells. These are extremely aggressive neoplasms which usually occur within soft tissue or bone of young adults. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare, with only few case reports in scientific literature. Due to being so exceedingly rare, PNETs are frequently misdiagnosed and there are no standard therapeutic guidelin...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Tiberiu Augustin Georgescu Antonia Carmen Georgescu Andrei Dennis Voichi ţoiu Drago ş Creţoiu Nicolae Suciu Adriana Irina Ciuvic ă Source Type: research
Immunoexpression of Ki67, P16 and Beta-catenin in precursor lesions of cutaneous squamous cell carcinoma
In this study, we analyzed the expression of Ki67, P16 and Beta-catenin in the precursor lesions of CSCC in relation to histological prognostic parameters, respectively between them, with the aim of identifying possible correlations with a role in prognosis. Ki67 and P16 presented higher scores in advanced precancerous lesions, such as keratinocyte intraepithelial neoplasia (KIN) III and BD and low scores in seborrheic keratosis (SK). The immunoreactivity to the investigated markers confirms the multistage skin carcinogenesis, and their involvement starting from the initiation phase of the cancer process. The importance of...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Alina Maria V îlcea Loredana Elena Stoica Bianca C ătălina Andreiana Cecil Sorin Mirea Tiberiu Ştefăniţă Ţenea Cojan Ioana Cristina V îlcea Claudiu M ărgăritescu Source Type: research
Epidemiological and histopathological aspects of ocular melanomas in Northeastern Romania
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):35-44. doi: 10.47162/RJME.65.1.05.ABSTRACTOcular melanoma is a rare but complex disease in current medical practice. Our retrospective study spans over a period of 28 years and analyzed uveal and conjunctival melanomas that were consecutively admitted, diagnosed, and treated in the 2nd Ophthalmology Clinic of Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania. The patients were selected from the records of the Department of Pathology of our Hospital, being diagnosed by standard histopathological techniques. The aim of this study was to summarize the epidemiological ...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Claudia Florida Costea Andrei Ionu ţ Cucu Gabriela Floren ţa Dumitrescu Anca Sava Gabriela Dimitriu Tina Bo ţoc Mihaela Roxana Popescu C ătălin Mihai Buzdugă Ana Maria Dumitrescu Alexandra St ărică Georgiana Macovei Iulian Prutianu Lauren ţiu And Source Type: research
