The role of fine-needle aspiration biopsy in the diagnosis of malignant tumors
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):81-87. doi: 10.47162/RJME.65.1.10.ABSTRACTCytopathology and histopathology play a key role in the process of diagnosing oncological diseases and premalignant conditions. Fine-needle aspiration (FNA) is one of the techniques used for obtaining biopsy of a wide variety of body tissues, causing patients minimal discomfort. Therefore, it is often considered to be the best strategy for investigating and diagnosing some precancerous or potential malignant lesions. Being successful as a means of confirming the clinical suspicion of metastatic recurrence in the cases of an already known ca...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Marius Rus Mircea Ioachim Popescu Ioana Adrian Ardelean Felicia Liana Andronie-Cioar ă Mihaela Gabriela Bon ţea R ăzvan Marius Vicaş Iulia Denisa Bogdan Source Type: research
Effects of quercetin on gentamicin-induced experimental testicular injury in rats
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):69-80. doi: 10.47162/RJME.65.1.09.ABSTRACTThe purpose of this study was to investigate the effects of gentamicin (GEN) on the testis and whether quercetin (QUE) has any protective effect. Twenty-four adult male Sprague-Dawley rats were divided into equal four groups: control (0.9% saline solution), GEN (80 mg∕kg GEN), QUE (50 mg∕kg QUE) and GEN+QUE (80 mg∕kg GEN + 50 mg∕kg QUE). Histopathological (HP) evaluation of testis was performed, epididymal sperm parameters were analyzed and oxidative status was evaluated. The use of QUE improved the HP findings, such as decrease in ...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Ayse Firuze Biyik Esin Yulug Engin Yenilmez Abdulkadir Kutlu Ahmet Alver Seniz Erdem Source Type: research
Endothelial cell proliferation and vascular patterns in urothelial carcinoma
CONCLUSIONS: The vascular patterns may contribute to a better stratification of the patient subgroups and antiangiogenic treatment algorithms.PMID:38527985 | DOI:10.47162/RJME.65.1.08 (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Tiberiu Gabriel Adelmann Amalia Raluca Ceau şu Nela Pu şa Gaje Marius Raica Source Type: research
Ultrastructural changes of lung tissue under conditions of experimental obesity and smoking
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):53-59. doi: 10.47162/RJME.65.1.07.ABSTRACTObesity can cause respiratory disorders inflicted by adipose tissue accumulation and the numerous cytokines adipocytes produce. Smoking is, first of all, associated with a wide range of lung diseases characterized by diffuse changes in the lung tissue and a decrease in the respiratory volume of the lungs. The study aimed to investigate the ultrastructural changes in the lungs of sexually mature male rats under conditions of experimental obesity and smoking. The total sample of experimental animals consisted of 120 rats, divided into four gr...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Yuliia Kuzyk Olena Mazur Yuryj Bisyarin Source Type: research
MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination
CONCLUSIONS: This study emphasizes the roles of MMP1, MMP9, and MMP13 in the process of metastasis in melanoma and the opportunity to use them as therapeutic targets and surveillance molecules.PMID:38527983 | DOI:10.47162/RJME.65.1.06 (Source: Romanian Journal of Morphology and Embryology)
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Bogdan Stelian Mastalier Manolescu Angela M ădălina Lazar George Sorin Ţiplica Sabina Andrada Zurac Adrian Rebo şapcă Bogdan Andreescu Cristiana Gabriela Popp Source Type: research
Epidemiological and histopathological aspects of ocular melanomas in Northeastern Romania
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):35-44. doi: 10.47162/RJME.65.1.05.ABSTRACTOcular melanoma is a rare but complex disease in current medical practice. Our retrospective study spans over a period of 28 years and analyzed uveal and conjunctival melanomas that were consecutively admitted, diagnosed, and treated in the 2nd Ophthalmology Clinic of Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania. The patients were selected from the records of the Department of Pathology of our Hospital, being diagnosed by standard histopathological techniques. The aim of this study was to summarize the epidemiological ...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Claudia Florida Costea Andrei Ionu ţ Cucu Gabriela Floren ţa Dumitrescu Anca Sava Gabriela Dimitriu Tina Bo ţoc Mihaela Roxana Popescu C ătălin Mihai Buzdugă Ana Maria Dumitrescu Alexandra St ărică Georgiana Macovei Iulian Prutianu Lauren ţiu And Source Type: research
Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines
In this study, we aimed to investigate the effects of 4-Hydroperoxy cyclophosphamide (4-HC), which is active form of CP, on glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), phospho-protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (p-PERK), phospho-inositol-requiring enzyme 1 alpha (p-IRE1α), eukaryotic translation initiation factor 2 alpha (eIF2α), and caspase-3 messenger ribonucleic acids (mRNAs) and proteins that play roles in the ER stress pathway and apoptosis in U87 and T98 human glioblastoma cell lines. U87 and T98 human glioblastoma cell lines were divided into control a...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Mustafa Oztatlici Hulya Oztatlici Suna Karadeniz Saygili Ismail Kaya Ilker Deniz Cingoz Source Type: research
Immunoexpression of Ki67, P16 and Beta-catenin in precursor lesions of cutaneous squamous cell carcinoma
In this study, we analyzed the expression of Ki67, P16 and Beta-catenin in the precursor lesions of CSCC in relation to histological prognostic parameters, respectively between them, with the aim of identifying possible correlations with a role in prognosis. Ki67 and P16 presented higher scores in advanced precancerous lesions, such as keratinocyte intraepithelial neoplasia (KIN) III and BD and low scores in seborrheic keratosis (SK). The immunoreactivity to the investigated markers confirms the multistage skin carcinogenesis, and their involvement starting from the initiation phase of the cancer process. The importance of...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Alina Maria V îlcea Loredana Elena Stoica Bianca C ătălina Andreiana Cecil Sorin Mirea Tiberiu Ştefăniţă Ţenea Cojan Ioana Cristina V îlcea Claudiu M ărgăritescu Source Type: research
Neurobiological mechanisms and therapeutic impact of electroconvulsive therapy (ECT)
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):13-17. doi: 10.47162/RJME.65.1.02.ABSTRACTElectroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefrontal region of the brain and spreads to the cortex and subcortex, including the diencephalic structures. This is achieved by creating a transcranial electric field and synchronously depolarizing neuronal membranes. The mechanisms of action of EC...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Ana Maria Cojocaru Antonia Ioana Vasile Simona Corina Trifu Source Type: research
Primitive neuroectodermal tumors of the ovary: a multidecade review of the scientific literature
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):5-12. doi: 10.47162/RJME.65.1.01.ABSTRACTPrimitive neuroectodermal tumor (PNET) is a general term used in scientific literature for a heterogeneous group of small round-cell malignant tumors primarily arising from neural crest cells. These are extremely aggressive neoplasms which usually occur within soft tissue or bone of young adults. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare, with only few case reports in scientific literature. Due to being so exceedingly rare, PNETs are frequently misdiagnosed and there are no standard therapeutic guidelin...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Tiberiu Augustin Georgescu Antonia Carmen Georgescu Andrei Dennis Voichi ţoiu Drago ş Creţoiu Nicolae Suciu Adriana Irina Ciuvic ă Source Type: research
Neurobiological mechanisms and therapeutic impact of electroconvulsive therapy (ECT)
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):13-17. doi: 10.47162/RJME.65.1.02.ABSTRACTElectroconvulsive therapy (ECT) is an efficient therapeutic resource for psycho-pharmacotherapeutic resistant forms of depression. ECT is a form of electrical brain stimulation involving the induction of a controlled seizure, clinically similar to an epileptic seizure, that is initiated in the prefrontal region of the brain and spreads to the cortex and subcortex, including the diencephalic structures. This is achieved by creating a transcranial electric field and synchronously depolarizing neuronal membranes. The mechanisms of action of EC...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Ana Maria Cojocaru Antonia Ioana Vasile Simona Corina Trifu Source Type: research
Ultrastructural changes of lung tissue under conditions of experimental obesity and smoking
Rom J Morphol Embryol. 2024 Jan-Mar;65(1):53-59. doi: 10.47162/RJME.65.1.07.ABSTRACTObesity can cause respiratory disorders inflicted by adipose tissue accumulation and the numerous cytokines adipocytes produce. Smoking is, first of all, associated with a wide range of lung diseases characterized by diffuse changes in the lung tissue and a decrease in the respiratory volume of the lungs. The study aimed to investigate the ultrastructural changes in the lungs of sexually mature male rats under conditions of experimental obesity and smoking. The total sample of experimental animals consisted of 120 rats, divided into four gr...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Yuliia Kuzyk Olena Mazur Yuryj Bisyarin Source Type: research
Immunoexpression of Ki67, P16 and Beta-catenin in precursor lesions of cutaneous squamous cell carcinoma
In this study, we analyzed the expression of Ki67, P16 and Beta-catenin in the precursor lesions of CSCC in relation to histological prognostic parameters, respectively between them, with the aim of identifying possible correlations with a role in prognosis. Ki67 and P16 presented higher scores in advanced precancerous lesions, such as keratinocyte intraepithelial neoplasia (KIN) III and BD and low scores in seborrheic keratosis (SK). The immunoreactivity to the investigated markers confirms the multistage skin carcinogenesis, and their involvement starting from the initiation phase of the cancer process. The importance of...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Alina Maria V îlcea Loredana Elena Stoica Bianca C ătălina Andreiana Cecil Sorin Mirea Tiberiu Ştefăniţă Ţenea Cojan Ioana Cristina V îlcea Claudiu M ărgăritescu Source Type: research
Cyclophosphamide stimulates endoplasmic reticulum stress and induces apoptotic cell death in human glioblastoma cell lines
In this study, we aimed to investigate the effects of 4-Hydroperoxy cyclophosphamide (4-HC), which is active form of CP, on glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), phospho-protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (p-PERK), phospho-inositol-requiring enzyme 1 alpha (p-IRE1α), eukaryotic translation initiation factor 2 alpha (eIF2α), and caspase-3 messenger ribonucleic acids (mRNAs) and proteins that play roles in the ER stress pathway and apoptosis in U87 and T98 human glioblastoma cell lines. U87 and T98 human glioblastoma cell lines were divided into control a...
Source: Romanian Journal of Morphology and Embryology - March 26, 2024 Category: General Medicine Authors: Mustafa Oztatlici Hulya Oztatlici Suna Karadeniz Saygili Ismail Kaya Ilker Deniz Cingoz Source Type: research
