TPR Podcast Episode #6: I’m tripping and I can’t get down
TPR Podcast Episode 6: I’ve Tripped and I Can’t Get Down
Written by Theresa Kim, MD
Outline
1) Synthetic cathinones
2) Piperazine compounds
3) Gamma-hydroxybutyric acid (GHB)
4) 25C-NBOMe
This month’s podcast was inspired by the New York Times article “A Year After Drug Deaths, the Electric Zoo Music Festival Tries Again” which covered designer drug related deaths associated with summer music festivals
Synthetic Cathinones
Derivatives of the Catha edulis (khat) plant’s psychoactive alkaloid (cathinone)
o examples: mephedrone, methedrone, MD...
Source: The Poison Review - October 7, 2014 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news
Two cases of laboratory-confirmed exposure to 25B-NBOMe
25I-NBOMe blotter paper
3 out of 5 stars
Two cases of severe intoxication associated with analytically confirmed use of the novel psychoactive substances 25B-NBOMe and 25C-NBOMe. Tang MHY et al. Clin Toxicol 2014 Jun;52:561-565.
Abstract
The NBOMe series of drugs are substituted phenethylamines. They act as agonists at both the 5-HT2A receptors and the α-receptors. Because of these actions, they can cause both hallucinations (5-HT2A effects) and sympathomimetic toxidrome (α effects.) Since these drugs are so potent, they are often sold in the form of impregnated blotter paper.
This paper, from Hong Kong, describes ...
Source: The Poison Review - July 18, 2014 Category: Toxicology Authors: Leon Tags: Medical 25B-NBOMe 25C-NBOME 25I-NBOMe blotter paper hallucinogenics sympathomimetic toxidrome Source Type: news
'More adults should be taking statins,' says NICE
Conclusion
Despite somewhat hysterical media coverage to the contrary ("millions more to be given statins," according to the Daily Express), nobody will be forced to take statins.
If your GP does recommend statins, you should ask them to explain the benefits and risks for you personally of starting statin treatment. You may want to find out more about statins before making up your mind – the NHS Choices Health A-Z information on statins is a good place to start.
If you do experience troublesome side effects while taking statins, contact your GP or the doctor in charge of your care. It could be the case that a...
Source: NHS News Feed - July 18, 2014 Category: Consumer Health News Tags: Heart/lungs Medication QA articles Source Type: news
Rubbing alcohol toxicity
3.5 out of 5 stars
Isopropanol poisoning. slaughter RJ et al. Clin Toxicol 2014 May 9 [Epub ahead of print]
Abstract
This comprehensive and well done review article will tell you perhaps more than you wanted to know about isopropyl alcohol poisoning.
This is, frankly, not the sexiest topic in medical toxicology, since isopropanol ingestion generally responds to supportive care and rarely causes death. However, for those who want to get granular on the subject, this is now the go-to paper.
Some key points:
Isopropanol is rapidly absorbed, mostly in the first 30 minutes after ingestion.
Isopropanol toxicity typically pres...
Source: The Poison Review - May 31, 2014 Category: Toxicology Authors: Leon Tags: Medical isopropanol isopropyl alcohol Review rubbing alcohol Source Type: news
Statins aren't a wonder drug | Malcolm Kendrick
The claims made for statins are overblown. They are not a cure for most of the major diseases afflicting western civilisationStatins are the most widely prescribed drugs in medical history. They appear to have effortlessly conquered heart disease. If guidance proposed by Nice – the National Institute for Health and Care Excellence – is followed, 15 million people in the UK, most with no history of heart disease, could soon be taking them.A recent study by researchers at Imperial College London made the claim that "statins have virtually no side effects, with users experiencing fewer adverse symptoms than if they had ta...
Source: Guardian Unlimited Science - March 23, 2014 Category: Science Authors: Malcolm Kendrick Tags: Comment The Guardian World news Health Health policy Society Drugs UK news Statins Comment is free Source Type: news
Statins aren't a wonder drug | Malcolm Kendrick
This article was corrected on 24 March 2014. It originally said in the eighth paragraph: "Flecainide suppressed dangerous heart arrhythmias, but was pulled from the market for killing thousands of people." This has been amended, as the drug that was pulled from the market was encainide, not flecainide.StatinsDrugsHealthHealth policyMalcolm Kendricktheguardian.com © 2014 Guardian News and Media Limited or its affiliated companies. All rights reserved. | Use of this content is subject to our Terms & Conditions | More Feeds (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - March 23, 2014 Category: Science Authors: Malcolm Kendrick Tags: Statins Drugs Health Health policy Society UK news World news The Guardian Comment Comment is free Source Type: news
Right bundle branch block: an uncommon cardiotoxic manifestation of hair dye poisoning-a case report - Balasubramanian D, Subramanian S, Thangaraju P, Shanmugam K.
Hair dye poisoning has been rising in incidence in the recent years. Apart from the commoner manifestations of upper airway edema, rhabdomyolysis and acute renal failure, cardiac toxicity, convulsions and sudden cardiac death are relatively rare complicati... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 15, 2014 Category: Global & Universal Tags: Poisoning Source Type: news
What Are Complications of Fractures?
Discussion
Fifth metatarsal fractures are a common fracture of the foot and are the most common metatarsal fracture in children > 5 years of age and adults. There is a peak age distribution in the second and fifth decades of life. Teenage boys in organized sports are one of the most common groups affected. In acute fractures, acute pain and inability to walk are common presentations, whereas in a stress fracture an increase in activity, or chronic repetitive forces are at play. Fifth metatarsal fractures have various classifications. Fracture locations from proximal to distal include avulsion fractures (a common acute f...
Source: PediatricEducation.org - March 10, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
A baby with symmetrical hand injuries and rhabdomyolysis following nonfatal electrocution by an unusual mechanism - Hon KL, Tse WL, Cheung HM, Yip ST, Cheung KL, Wong W.
We report the case of a 21-month boy with severe electrical injuries of both hands and explored underlying mechanism for the incident. Meticulous orthopedic repair and reconstruction ensures ... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 28, 2014 Category: Global & Universal Tags: Age: Infants and Children Source Type: news
Causes of rhabdomyolysis in acute poisonings - Janković SR, Stosić JJ, Vucinić S, Vukcević NP, Ercegović GV.
BACKGROUND/AIM: Rhabdomyolysis (RM) is potentially lethal syndrome, but there are no enough published data on its frequency and characteristics in acute poisonings. The aim of this study was to determine the causes and severity of RM in acute poisonings. M... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 15, 2014 Category: Global & Universal Tags: Poisoning Source Type: news
CDC report on “Crazy Clown” synthetic cannabinoid exposure in Georgia
3.5 out of 5 stars
Severe Illness Associated with Synthetic Cannabinoid Use — Brunswick, Georgia, 2013. MMWR 2013 Nov 22;62:939.
Full Text
Back in August, TPR noted sketchy news reports describing multiple patients who were seen in emergency departments in southern Georgia after smoking a synthetic cannabinoid product labeled as “Crazy Clown.” Some were in critical condition requiring ICU admission. At that time, it was not clear exactly what drug or drugs were involved.
Today, the CDC released their report on the incident. A total of 22 patients were seen in the Brunswick, Georgia hospital after using sy...
Source: The Poison Review - November 22, 2013 Category: Toxicology Authors: Leon Tags: Medical CDC crazy clown georgia mmwr synthetic cannabinoid Source Type: news
Rhabdomyolysis
Title: RhabdomyolysisCategory: Diseases and ConditionsCreated: 4/7/2009 12:00:00 AMLast Editorial Review: 11/8/2013 12:00:00 AM (Source: MedicineNet Cholesterol General)
Source: MedicineNet Cholesterol General - November 8, 2013 Category: Cardiology Source Type: news
Furosemide-Induced Severe Hypokalemia With RhabdomyolysisFurosemide-Induced Severe Hypokalemia With Rhabdomyolysis
Find out about a very different kind of drug abuse with life threatening consequences. BMC Women's Health (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 4, 2013 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news
Perils and Pitfalls of Long-term Effects of PPIsPerils and Pitfalls of Long-term Effects of PPIs
PPIs are associated with adverse effects such as thrombocytopenia, rhabdomyolysis, and acute interstitial nephritis. Expert Review of Clinical Pharmacology (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - September 27, 2013 Category: Gastroenterology Tags: Gastroenterology Journal Article Source Type: news
Tumors (skin and GI) and Rhabdomyolysis
Which of these GI and skin lesions should you worry about most? Is rhabdomyolysis usually the result of infection? See how well you do with this week’s questions. . . (Source: Consultant Live)
Source: Consultant Live - September 17, 2013 Category: Primary Care Source Type: news
