Rhabdomyolysis in 114 patients with acute poisonings - Mousavi SR, Vahabzadeh M, Mahdizadeh A, Vafaee M, Sadeghi M, Afshari R, Balali-Mood M.
BACKGROUND: Rhabdomyolysis is a clinical and biochemical syndrome, which is observed in some patients with acute chemical and/or pharmaceutical poisonings. We aimed to investigate rhabdomyolysis in patients with acute poisonings due to different chemicals,... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 4, 2015 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
A case report about skinny jeans sparks media frenzy
Conclusion
This study describes a case where the combination of squatting for a prolonged period while wearing skinny jeans seems to have led to severe ankle weakness.
With this kind of one-off event, it is difficult to be absolutely certain what causes it, but doctors look at the circumstances around the event and see what might explain it. They concluded that it was the extensive squatting that probably started the problem off, but once the woman's legs started to swell the jeans probably made it worse.
Given the fact that many people wear skinny jeans and this is the first report of this kind of severe problem, it is l...
Source: NHS News Feed - June 23, 2015 Category: Consumer Health News Tags: Lifestyle/exercise Neurology Source Type: news
Hair dye poisoning and rhabdomyolysis - Bokutz M, Nasir N, Mahmood F, Sajid S.
Hair dye ingestion is a rare cause of toxicity in Pakistan. We are presenting the case report of a 55 year old male who presented with accidental hair dye ingestion and developed laryngeal oedema requiring emergent tracheostomy. He had also developed aspir... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 23, 2015 Category: Global & Universal Tags: Home and Consumer Product Safety Source Type: news
A fatal outcome due to pulmonary hemorrhage following Russell's viper bite - Palangasinghe DR, Weerakkody RM, Dalpatadu CG, Gnanathasan CA.
Russell's viper (RV) envenomation causes local effects, coagulopathy, thrombosis, rhabdomyolysis, acute kidney injury, and neurological manifestations. Although coagulopathy and endothelial destruction causing local and mucosal surface bleeding is known, i... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 19, 2015 Category: Global & Universal Tags: Non-Human Animals and Insects Source Type: news
Severe reactions to “Spice” on rise, some associated with drug MAB-CHMINACA
AB-CHMINACA
3 out of 5 stars
In vitro and in vivo human metabolism of the synthetic cannabinoid AB-CHMINACA Erratico C et al. Drug Test Analysis 2015 Apr 12 [Epub ahead of print]
Abstract
The New York Times reported today on the recent dramatic increase in emergency department visits related to use of synthetic cannabinoids (call colloquially, but somewhat inaccurately, “Spice”). This phenomenon has been seen in many states, especially Mississippi, Pennsylvania, and New York.
According to reports, patients often present with agitation, delirium, and hallucinations. Medical complications have included rhabdo...
Source: The Poison Review - April 25, 2015 Category: Toxicology Authors: Leon Tags: Medical CHMINACA spice synthetic cannabinoid Source Type: news
Poisonous birds: what’s new
3 out of 5 stars
Poisonous birds: A timely review. Ligabue-Braun R, Carlini CR. Toxicon 2015 Mar 31;99:102-108.
Abstract
It was just over two decades ago that Dumbacher et al published their landmark paper describing the presence of the alkaloid batrachotoxin (BTX, “frog poison”) in the skin and feathers of three species of Pitohui bird in New Guinea. This toxin binds to voltage-gated sodium channels maintaining them in the open position. This action causes depolarization of nerves and myocardial cells. This may serve the bird by acting as a “chemical defense” against large predators, or as a ...
Source: The Poison Review - April 21, 2015 Category: Toxicology Authors: Leon Tags: Medical batrachotoxin bird catharidin coturnism hoopoe pitohui bird poison quail rhabdomyolysis spur-winged goose toxicity Source Type: news
27 fatalities from laboratory-confirmed exposure to PMMA (“Dr. Death”)
4 out of 5 stars
Deaths from exposure to paramethoxymethamphetamine in Alberta and British Columbia, Canada: a case series. Nicol JJE et al. CMAJ Open. 2015 Jan 13;3(1):E83-9
Full Text
From June 2011 through April 2012, 27 deaths in the Canadian provinces of Albert and British Columbia were attributed to the hallucinogenic stimulant para-methoxy-N-methylamphetamine (PMMA) as the primary toxic agent based postmortem examination and toxicology results. PMMA is so dangerous that it is known on the street as “Death” and “Dr. Death.” This paper constitutes a retrospective review of those cases based on r...
Source: The Poison Review - April 18, 2015 Category: Toxicology Authors: Leon Tags: Best of TPR Medical alberta bath salt british columbia canada death dr. death ecstasy fatality hyperthermia mdma PMMA serotonin syndrome synthetic designer drug Source Type: news
How Long Do Creatine Kinase Levels Remain Elevated After Exercise?
Discussion
Acute rhabdomyolysis is an emergency that can cause acute renal failure (especially acute tubular necrosis caused by myoglobinemia) and electrolyte abnormalities. Common presenting findings are dark urine, myalgia and muscle weakness. Milder episodes can go unnoticed. Acute exertional rhabdomyolysis or unrecognized muscle injury can occur in underconditioned persons and even trained athletes who increase their exertion or exercise. Being unaccustomed to the ambient conditions such as heat, humidity and sun can also increase fluid loss and the risk of muscle injury. An overview and differential diagnosis of rhab...
Source: PediatricEducation.org - April 13, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Creatine Phosphokinase (CPK) Test: Facts & Information
Creatine phosphokinase or, ‘CPK,’ is an enzyme found in high concentrations in a person’s muscles where it facilitates a person’s muscle contraction. CPK is also referred to as, ‘creatine kinase,’ or, ‘CK.’ A doctor might check a person’s CPK when they are concerned a person has experienced muscle damage or breakdown. In a rare condition called, ‘rhabdomyolysis,’ extreme muscle breakdown floods a person’s blood with CPK and additional chemicals in their muscle cells. Some of these are toxic to a person’s kidneys, making the condition a dangerous one. A doctor might repeatedly check a person’s CP...
Source: Disabled World - March 17, 2015 Category: Disability Tags: Health and Disability Source Type: news
Creatine Phosphokinase (CPK) Test Information
A creatine phosphokinase test may be used to detect inflammation of muscles or serious muscle damage, or to diagnose rhabdomyolysis (Source: Disabled World)
Source: Disabled World - March 17, 2015 Category: Disability Tags: Health and Disability Source Type: news
Do medical toxicologists use physostigmine to treat anticholinergic toxidrome?
2.5 out of 5 stars
The Use of Physostigmine by Toxicologists in Anticholinergic Toxicity. Watkins JW et al. J Med Toxicol 2014 Dec 16 [Epub ahead of print]
Abstract
Physostigmine is a carbamate that reversibly inhibits acetylcholinesterase, the enzyme that breaks down acetylcholine (ACh). By so doing, it increases the levels of ACh in synapses, serving as an antidote for drugs and agents causing anticholinergic syndrome. Unlike neostigmine, physostigmine crossed the blood-brain-barrier and has both peripheral and central effects.
Decades ago, physostigmine was routinely used with some frequency to treat overdose with ...
Source: The Poison Review - February 18, 2015 Category: Toxicology Authors: Leon Tags: Medical anticholinergic toxidrome physostigmine ToxIC registry Source Type: news
Death after injecting alpha-PVP
3 out of 5 stars
Death due to intravenous use of α-pyrrolidinopentiophenone. Sellors K et al. Med J Aust 2014 Nov 17;201:601-3.
Full Text
α-pyrrolidinopentiophenone (α-PVP) is a synthetic cathinone stimulant with structural similarities to MDPV. Like MDPV, α-PVP contains a pyrrolidine ring, a 5-sided nitrogen-containing component that enables the molecule to effectively block reuptake of dopamine and norepinephrine, with much weaker effects at the serotonin transporter.
This dramatic case report describes a 44-year-old man who injected a product labelled “Smokin’ Slurries Scrubba” (α-PVP) intrave...
Source: The Poison Review - December 31, 2014 Category: Toxicology Authors: Leon Tags: Medical agitted delirium alphya-PVP death fatality MDPV Source Type: news
Rhabdomyolysis Symptoms and Causes
Title: Rhabdomyolysis Symptoms and CausesCategory: Doctor's & Expert's views on SymptomsCreated: 1/28/2011 12:00:00 AMLast Editorial Review: 12/29/2014 12:00:00 AM (Source: MedicineNet Cholesterol General)
Source: MedicineNet Cholesterol General - December 29, 2014 Category: Cardiology Source Type: news
Palytoxin: deadlier than fugu?
Palytoxin
3 out of 5 stars
Hyperkalemia, Hyperphosphatemia, Acute Kidney Injury, and Fatal Dysrhythmias After Consumption of Palytoxin-Contaminated Goldspot Herring. Wu M: et al. Ann Emerg Med 2014 Dec;64:633-6.
Abstract
Palytoxin, a huge heat-stable molecule, is one of the most deadly of all the marine toxins. Fortunately, cases of severe palytoxin poisoning are relatively rare. This paper from Taiwan describes 4 patients from a single family who became symptomatic after eating fish soup made from the local catch. One person died. The presence of palytoxin was confirmed in samples of leftover fish.
The following question...
Source: The Poison Review - December 5, 2014 Category: Toxicology Authors: Leon Tags: Medical fish poisoning Goldspot herring marine palytoxin Source Type: news
Haff Time: fish-induced rhabdomyolysis
Buffalo fish (Ictiobus cyprinellus)
3 out of 5 stars
Haff Disease: Rhabdomyolysis After Eating Buffalo Fish. Herman LL, Bies C. West J Emerg Med 2014 Sept;15:664-6.
Abstract
Haff Disease was first described in 1924 after an outbreak of acute muscle rigidity accompanied by dark urine among patients living near the Königsberger Haff shores along the Baltic Coast. Similar cases occurred in the following summers along the haff (a shallow lagoon.) Most victims gave a history of recently ingesting various fish — burbot, eel, pike, etc.
Cases of rhabdomyolysis after ingesting fish were not reported in the United States u...
Source: The Poison Review - November 24, 2014 Category: Toxicology Authors: Leon Tags: Medical fish poisoning haff disease palytoxin rhabdomyolysis Source Type: news
