Impact of pantoprazole on absorption and disposition of hydroxychloroquine, a drug used in Corona Virus Disease-19 (Covid-19): A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesPrimary objective: Evaluation of the effect of the proton pump inhibitor (PPI) pantoprazole on the absorption of hydroxychloroquine (HCQ).Secondary objectives:• Evaluation of the relationship between HCQ concentrations in whole blood, plasma and intracellular concentrations in target cells - peripheral blood mononuclear cells (PBMCs).• Evaluation of HCQ as a potential perpetrator in drug-drug interactions at the level of cytochrome P450 (CYP) 3A4 and CYP2D6 (major drug metabolizing enzymes).Trial designSingle centre, open-label, parallel group, two-arm, phase I drug-drug interaction trial.Participants...
Source: Trials - June 28, 2020 Category: Research Source Type: clinical trials
Effect of Obesity on Proton Pump Inhibitors
Conditions: Pediatric Obesity; NAFLD; GERD Intervention: Drug: Pantoprazole Sponsor: Children's Mercy Hospital Kansas City Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 30, 2020 Category: Research Source Type: clinical trials
