Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas
Conditions:   Primary Central Nervous System Lymphoma;   Secondary Central Nervous System Lymphoma;   Relapsed Cancer;   Refractory Cancer Interventions:   Drug: Pemetrexed;   Drug: Zanubrutinib;   Procedure: Autologous Stem Cell Transplant (ASCT);   Radiation: Whole Brain Radiation Therapy (WBRT) Sponsors:   Baptist Health South Florida;   BeiGene Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 12, 2023 Category: Research Source Type: clinical trials

Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes) for the Treatment of Primary Central Nervous System Lymphoma
Condition:   Central Nervous System Lymphoma Interventions:   Procedure: Aspiration;   Procedure: Biospecimen Collection;   Procedure: Catheterization;   Biological: CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes;   Procedure: Computed Tomography;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Procedure: Leukapheresis;   Procedure: Lumbar Puncture;   Procedure: Magnetic Resonance Imaging;   Procedure: Positron Emission Tomography Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 23, 2022 Category: Research Source Type: clinical trials