Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes) for the Treatment of Primary Central Nervous System Lymphoma

Condition:   Central Nervous System Lymphoma Interventions:   Procedure: Aspiration;   Procedure: Biospecimen Collection;   Procedure: Catheterization;   Biological: CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes;   Procedure: Computed Tomography;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Procedure: Leukapheresis;   Procedure: Lumbar Puncture;   Procedure: Magnetic Resonance Imaging;   Procedure: Positron Emission Tomography Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials