Case Report: Variegate porphyria disclosed by post-gastric bypass complications and causing predominant painful sensorimotor axonal peripheral neuropathy
Conclusion: This case documents gastric bypass surgery as a trigger of severe VP invalidating neurological symptoms and illustrates how the delayed diagnosis and post-interventional complications could have been prevented by screening for porphyria cardinal symptoms prior to the intervention. Likewise, this cost-effective screening should be performed before any treatment influencing the diet, which would dramatically improve the porphyria diagnosis rate and outcome. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - October 31, 2022 Category: Genetics & Stem Cells Source Type: research
Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil
This article evaluates the weight of evidence for this MOA based on the modified Bradford Hill criteria. The MOA data were aligned with the dose and temporal concordance, biological plausibility, coherence, strength, consistency, and specificity for a porphyria-mediated cytotoxicity MOA while excluding other alternative MOAs. Although the postulated MOA could qualitatively potentially occur in humans, we demonstrate that it is unlikely to occur in humans because of quantitative toxicodynamic and toxicokinetic differences between mice and humans. Therefore, this MOA is considered not relevant to humans, utilizing the IPCS H...
Source: Regulatory Toxicology and Pharmacology : RTP - October 9, 2022 Category: Toxicology Authors: Satoki Fukunaga Keiko Ogata Ayumi Eguchi Kohei Matsunaga Kengo Sakurai Jun Abe Samuel M Cohen Hiroyuki Asano Source Type: research
Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil
This article evaluates the weight of evidence for this MOA based on the modified Bradford Hill criteria. The MOA data were aligned with the dose and temporal concordance, biological plausibility, coherence, strength, consistency, and specificity for a porphyria-mediated cytotoxicity MOA while excluding other alternative MOAs. Although the postulated MOA could qualitatively potentially occur in humans, we demonstrate that it is unlikely to occur in humans because of quantitative toxicodynamic and toxicokinetic differences between mice and humans. Therefore, this MOA is considered not relevant to humans, utilizing the IPCS H...
Source: Regulatory Toxicology and Pharmacology : RTP - October 9, 2022 Category: Toxicology Authors: Satoki Fukunaga Keiko Ogata Ayumi Eguchi Kohei Matsunaga Kengo Sakurai Jun Abe Samuel M Cohen Hiroyuki Asano Source Type: research
Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil
This article evaluates the weight of evidence for this MOA based on the modified Bradford Hill criteria. The MOA data were aligned with the dose and temporal concordance, biological plausibility, coherence, strength, consistency, and specificity for a porphyria-mediated cytotoxicity MOA while excluding other alternative MOAs. Although the postulated MOA could qualitatively potentially occur in humans, we demonstrate that it is unlikely to occur in humans because of quantitative toxicodynamic and toxicokinetic differences between mice and humans. Therefore, this MOA is considered not relevant to humans, utilizing the IPCS H...
Source: Regulatory Toxicology and Pharmacology : RTP - October 9, 2022 Category: Toxicology Authors: Satoki Fukunaga Keiko Ogata Ayumi Eguchi Kohei Matsunaga Kengo Sakurai Jun Abe Samuel M Cohen Hiroyuki Asano Source Type: research
Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil
This article evaluates the weight of evidence for this MOA based on the modified Bradford Hill criteria. The MOA data were aligned with the dose and temporal concordance, biological plausibility, coherence, strength, consistency, and specificity for a porphyria-mediated cytotoxicity MOA while excluding other alternative MOAs. Although the postulated MOA could qualitatively potentially occur in humans, we demonstrate that it is unlikely to occur in humans because of quantitative toxicodynamic and toxicokinetic differences between mice and humans. Therefore, this MOA is considered not relevant to humans, utilizing the IPCS H...
Source: Regulatory Toxicology and Pharmacology : RTP - October 9, 2022 Category: Toxicology Authors: Satoki Fukunaga Keiko Ogata Ayumi Eguchi Kohei Matsunaga Kengo Sakurai Jun Abe Samuel M Cohen Hiroyuki Asano Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Pain Physician)
Source: Pain Physician - September 13, 2022 Category: Anesthesiology Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Pain Physician)
Source: Pain Physician - September 13, 2022 Category: Anesthesiology Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
A case of pink urine associated with abdominal pain crisis
Ann Biol Clin (Paris). 2022 Jul 1;80(4):389-392. doi: 10.1684/abc.2022.1743.ABSTRACTAn adolescent girl consults a physician for abdominal pain attacks occurring regularly for 2 years. After eliminating gastroenterologic or gynecologic causes, an acute hepatic porphyria is suspected. The pink color of her urine seems consistent with the suspicion of porphyria; however, the urinary profile of porphyrins and its precursors is normal.PMID:36099345 | DOI:10.1684/abc.2022.1743 (Source: Annales de Biologie Clinique)
Source: Annales de Biologie Clinique - September 13, 2022 Category: Biochemistry Authors: Emeline Gernez Isabelle Kim Claire Douillard Dries Dobbelaere Guillaume Grzych Source Type: research
