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TWiV 860: Evading a Toll on the road to RNA vaccines
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position RNA modifications suppress innate recognition (Immunity) Critical contribution of pseudouridine (Front Cell Dev Biol) Rich Condit reminisces (YouTube) Letters read ...
Source: This Week in Virology - MP3 Edition - January 30, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 859: COVID-19 clinical update #99 with Dr. Daniel Griffin
In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron disease severity (MMWR) Neurologic manifestations in children (Pediatric Neurol) Respiratory virus interference (Emerg Inf Dis) Hospitalization by vaccination status (C...
Source: This Week in Virology - MP3 Edition - January 29, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 858: The vax of life with John Mascola
John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: John Mascola Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Accelerated COVID-19 vaccine development (Immunity) Letters read on TWiV 858 Timestamps by Jolene. Thanks! Weekly Picks Brianne – How Sesame Street is Handling the Pandemic Rich – Zamboni: How it works Alan – How lightning starts V...
Source: This Week in Virology - MP3 Edition - January 28, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 857: Not just antibody, Jon Yewdell
Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Jon Yewdell on TWiV 208, 467, 597, 620 Letters read on TWiV 857 Timestamps by Jolene. Thanks! Weekly Picks Jon – The Premonition by Michael Lewis Dickson – Nature photographer of the year 2021 Brianne – Should BioBank Volunteers Be Warned About Mutations? Rich ...
Source: This Week in Virology - MP3 Edition - January 23, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 856: COVID-19 clinical update #98 with Dr. Daniel Griffin
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic. Click arrow to play Download TWiV 853 (58 MB .mp3, 48 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 in South Africa (pdf) Ancestral T cells recogn...
Source: This Week in Virology - MP3 Edition - January 22, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 855: T time with Alessandro Sette
Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Alessandro Sette Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travel Award Applications (ASV) 3:20 Impact of variants on T cells (Cell Rep Med) Timestamps by Jolene. Thanks! Letters read on TWiV 855 Weekly Picks Brianne – 75 years of research on human diseases in 1 minute Kathy – 10 second video of COVID-19 spread...
Source: This Week in Virology - MP3 Edition - January 21, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 854: Omicron is evasive
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Travel Awa...
Source: This Week in Virology - MP3 Edition - January 16, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 853: COVID-19 clinical update #97 with Dr. Daniel Griffin
In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Quarantine and isolation (CDC) Outcomes before and after Omicron (medRxiv) Infectious viral load in Delta vs Omicron infecti...
Source: This Week in Virology - MP3 Edition - January 15, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 852: Tree man syndrome
A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) CD28 deficiency and severe warts (Cell) Vincent interviews Harald zur Hausen (virology blog) Letters read on TWiV 853 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Every Pore on Your Face Is a Walled Ga...
Source: This Week in Virology - MP3 Edition - January 13, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 851: Questions are tricky
The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) Omicron infection in mice and hamsters (Res Square) Letters read on TWiV 851 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Engineering the James Webb Space Telescope Amy – T cells might be our bodies’ best shot agai...
Source: This Week in Virology - MP3 Edition - January 9, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 850: COVID-19 clinical update #96 with Dr. Daniel Griffin
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant proportions (CDC) Omicron in South Africa (JAMA) Transmission of SARS-CoV-2 (Ann Int Med) Diagnostics for COVID-19 (Lancet) Comparison of rapid antigen tests (J Clin Med) Rapid antigen tests to reduce isolation (medRxiv) Frequency of viral confections (MMWR) Iso...
Source: This Week in Virology - MP3 Edition - January 8, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 849: Arc of the epitope
TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID vaccines: TWiV 708, 715, 718, 844 Non-CoV papers: TWiV 763, 784, 819, 822, 740, 848 Immune correlates of protection: TWiV 791, 799, 835, 832, 841, 789 Fitness: TWiV 705, 836, 768, 757 Guests off beaten track: 723, 726, 732, 838, 773, 745 Lab leak nonsense: TWiV 762, 774 One...
Source: This Week in Virology - MP3 Edition - January 7, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 847: On Dasher, on Dancer, on Corona and Lassa
For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codon-deoptimized Lassa fever vaccine (mBio) Attenuation of dengue virus by codon deoptimization (TWiV 351) Codon deoptimization of poliovirus and RS virus (TWiV 740) Codon deoptimization of DNA viruses (TWiV 362 lett...
Source: This Week in Virology - MP3 Edition - January 2, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 848: COVID-19 clinical update #95 with Dr. Daniel Griffin
In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Isolation and quarantine guidance (CDC) EUA for Molnupiravir (FDA) Children and COVID state data (AAP) Vaccine safety in 5-11 year olds (MMWR) Omicron and antigen tests (FDA) Omicron in Nebraska (MMWR) Omicron in Danish households (medRxiv) ...
Source: This Week in Virology - MP3 Edition - January 1, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 846: Beta was stirring, and now in a mouse
TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Impact of enteric virome on rotavirus vaccine (Cell Host Micr) Beta variant infects wild type mice (Sig Transd Targ Ther) Timestamps by Jolene. Thanks! Weekly Picks Brianne – XKCD on Immune Responses and Immunity Kathy – UVA Rotunda ...
Source: This Week in Virology - MP3 Edition - December 26, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts