TWiV 838: The magic virus bus
The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer, and Christine Marizzi, Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Biobus Wild Bird Fund FluLab B1.1.529 (COVID-19-lineages) Report on Omicron spike changes (virological) Omicro...
Source: This Week in Virology - MP3 Edition - December 5, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 837: COVID-19 clinical update #91 with Dr. Daniel Griffin
In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Update on Mol...
Source: This Week in Virology - MP3 Edition - December 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 836: OMG, Omicron!
TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cells in culture and induce membrane fusion. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron genome changes (Covariants) Omicron shared changes with other variants (Covariants) Update on Omicron (WHO) Spike polymutant PMS20 (bioRxiv) Syncytium formation of variants of concern (EMBO J) Variants as...
Source: This Week in Virology - MP3 Edition - December 2, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 835: Giving thanks for antibodies
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 vaccines for children (Science) Risk of infection with variants (medRxiv) Immune correlates of mRNA-1273 (Science) Letters read on TWiV 835 Timestamps by J...
Source: This Week in Virology - MP3 Edition - November 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 834: COVID-19 clinical update #90 with Dr. Daniel Griffin
In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Expanded eligibility for booster doses (FDA) More rapid antigen tests approved...
Source: This Week in Virology - MP3 Edition - November 27, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 833: Grand theft kinesin
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles. Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Early COVID-19 cases in Wuhan (Science) Herpesviruses assimilate kinesin (Nature) Letters read on TWiV 833 Timestamps by Jolene. Thanks! Weekly Picks Kathy – Power of poop Alan – Under the Sky We Make, by Kimberly Nicholas Vincent – Enzymatic amplification of beta-globing...
Source: This Week in Virology - MP3 Edition - November 25, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 832: Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Smallpox vials contain vaccinia virus (6abc.com) European re-emergence of enterovirus D68 (Eurosurveill) Efficacy of inactivated SARS-CoV-2 vaccine (Lancet) Cellular correlates of protection for oral flu vaccine (Cell Host M...
Source: This Week in Virology - MP3 Edition - November 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 831: COVID-19 clinical update #89 with Dr. Daniel Griffin
In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Scott Hammer on TWiV 52 Meeting for molnupiravir EUA (FDA) SARS-CoV-2 reinfection associates with antibodies (Clinical Inf Dis...
Source: This Week in Virology - MP3 Edition - November 20, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 830: A culture of resistance
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Click arrow to play Download TWiV 830 (67 MB .mp3, 112 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this ...
Source: This Week in Virology - MP3 Edition - November 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 829: Antiviral and cytotoxically empowered for COVID-19
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode How SARS-CoV-2 attacks olfactory mucosa (Cell) SARS-CoV-2-specific stem cell memory T cells after mRNA vaccine (Sci Immunol) Oral SARS-CoV-2 protease inhibitor (Science) Paxlovid phase 2/3 trial preliminary results (Pfizer) Lette...
Source: This Week in Virology - MP3 Edition - November 14, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 828: COVID-19 clinical update #88 with Dr. Daniel Griffin
In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine protection of US veterans (Science) Long term protection by REGEN-COV (Regeneron) Pfizer protease inhibitor Paxlovid phase 2/3 results (Pfizer...
Source: This Week in Virology - MP3 Edition - November 13, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 827: A shot to save the world with Greg Zuckerman
Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambitions, ego, and a desire to save the world. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Greg Zuckerman Click arrow to play Download TWiV 824 (76 MB .mp3, 127 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A Shot to Save the World (Hardcover, Kindle) Letters read on TWiV 827 Timestamps by Jolene. Thanks! Weekly Picks Dickson â...
Source: This Week in Virology - MP3 Edition - November 7, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 826: COVID-19 clinical update #87 with Dr. Daniel Griffin
In COVID-19 clinical update #87, Dr. Griffin reviews PCR cycle threshold and RNA copy number, rapid antigen tests, hospitalization rate after infection or vaccination, allergies and vaccination, community transmission and viral RNA load, early treatment with sotrovimab, meta-analysis of tocilizumab treatment, antibiotic overuse, and guidelines on the use of anticoagulation for thromboprophylaxis. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CDC vaccine nod to 5-11 year olds (CDC) Sensitivity of rapid antigen tests ...
Source: This Week in Virology - MP3 Edition - November 6, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts