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TWiV 874: COVID-19 clinical update #105 with Dr. Daniel Griffin
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infection and changes in brain structure (Nature) Dementia among pneumonia survivors (Open Forum Inf Dis) Narrative dynamics around COVID-19 vaccines (FSI) Children and COVID (AAP) Paxlovid in pediatric patients (Pfizer) Mask effectiveness i...
Source: This Week in Virology - MP3 Edition - March 12, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 873: Pig viruses and big viruses
TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Click arrow to play Download TWiV 873 (128 MB .mp3, 107 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Porcine coronaviruses (Virol Sin) Mimivirus nucleocapsid (bioRxiv) Letters read on TWiV 873 Timestamps by Jolene. Thanks! Weekly Picks Brianne â...
Source: This Week in Virology - MP3 Edition - March 6, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine effectiveness 5-11 year olds (medRxiv) Vaccine effectiveness vs ED and UCE 5-12 year olds (medRxiv)...
Source: This Week in Virology - MP3 Edition - March 5, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 871: If the ACE2 fits, ferret
TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registration (ASV) Microbiology & Immunology at LSU Health Is Omicron a new serotype? (Nat Rev Micr) Adaptation of SARS-CoV-2 to mink/ferret (Cell Rep) Letters read on T...
Source: This Week in Virology - MP3 Edition - February 27, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 870: COVID-19 clinical update #103 with Dr. Daniel Griffin
In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode What does society owe immunocompromised people (Atlantic) Prevalence of immunosuppression in US (JAME) Hospitali...
Source: This Week in Virology - MP3 Edition - February 26, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 869: Epstein-Barr virus and MS, a perfect storm
TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists ASV Annual Meeting Registration (ASV) Microbiology & Immunology at LSU Health Viremia in human poliomyelitis (J Exp Med) EBV associated with MS (Scienc...
Source: This Week in Virology - MP3 Edition - February 20, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 868: COVID-19 clinical update #102 with Dr. Daniel Griffin
In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children and COVID state data (AAP) Effectiveness of maternal vaccina...
Source: This Week in Virology - MP3 Edition - February 19, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 867: I love the smell of vaccines in the morning
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Dorothy Horstmann (Wikipedia) Intranasal SARS-CoV-2 experimental vaccine (Cell) t-SNE (Wikipedia) Timestamps by Jolene. Thanks! Weekly Picks Kathy – 477-mile-long megaflash lightning in Seattle Times (originally Washington Post) and extra info ...
Source: This Week in Virology - MP3 Edition - February 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 866: EV antibodies rEVolutionize our thinking
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Cross-reactive enterovirus antibodies (mBio) Poliovirus receptor transgenic mice (virology blog) Timestamps by Jolene. Thanks! Weekly Picks Di...
Source: This Week in Virology - MP3 Edition - February 13, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 865: COVID-19 clinical update #101 with Dr. Daniel Griffin
In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Children and COVID state data (AAP) Human challenge study (Res Sq) Effectiveness of mask use (MMWR) Omicron boost in macaques (bioRxiv) Mucosal vaccine candidate (Cell) Long-term cardiovascular outcomes (Nat Med) Global vaccine perceptions (PLoSNTD) Lette...
Source: This Week in Virology - MP3 Edition - February 12, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

259: Sea Sawdust
Mark Martin returns to TWiM for a discussion of the frightening global burden of bacterial antibiotic resistance, and a solution to the problem of daylight nitrogen fixation in a cyanobacterium, despite the incompatibility of nitrogenase with oxygen produced during photosynthesis. Become a patron of TWiM. Links for this episode: Global bacterial antimicrobial resistance (Nat Micro) Cancer moon shot (NCI) When antibiotics don’t work (TED) Cyanobacterium buoyancy (Nat Micro) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe...
Source: This Week in Virology - MP3 Edition - February 11, 2022 Category: Virology Authors: Vincent Racaniello, Elio Schaechter, Michele Swanson, Michael Schmidt, Mark O. Martin Source Type: podcasts

TWiV 864: A game of thrones
Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guests: John Dennehy, Marc Johnson, Davida Smyth, and Monica Trujillo Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode SARS-CoV-2 in NYC wastewater (TWiV 737) Cryptic SARS-CoV-2 in NYC wastewater (Nat Comm) Timestamps by Jolene. Thanks! Weekly Picks Brianne – When scientific conferences went on...
Source: This Week in Virology - MP3 Edition - February 10, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 863: Does this challenge study pass the smell test?
TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position 3:27 UK SARS-CoV-2 challenge study (Res Sq) U of Pennsylvania smell test (Wikipedia) Letters read on TWiV 863 Timesta...
Source: This Week in Virology - MP3 Edition - February 6, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 862: COVID-19 clinical update #100 with Dr. Daniel Griffin
In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Omicron severity challenges (NEJM) Children and COVID data (AAP) ...
Source: This Week in Virology - MP3 Edition - February 5, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 861: Rough draft of Omicron origins
Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Nels Elde Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Columbia University BSL-3 Manager position Did Omicron come from mice? (J Genet Genomics) Persistent SARS-CoV-2 infection (SSRN) Letters read on TWiV 861 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Groundhogs Emerge Fro...
Source: This Week in Virology - MP3 Edition - February 4, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts