Clinical trial protocol to evaluate the efficacy of cefixime in the treatment of early syphilis
This study evaluates the efficacy of oral cefixime for the treatment of early syphilis.MethodsWe are conducting a randomized, multisite, open-label, non-comparative clinical trial in Los Angeles and Oakland, CA. Eligible participants are ≥ 18 years old, with primary, secondary, or early latent syphilis (rapid plasma reagin [RPR] titer ≥ 1:8). Patients with HIV infection must have a viral load≤ 200 copies/mL and CD4+ T cell count ≥ 350 cells/μL during the past 6 months. Participants are randomized to receive either 2.4 M IU benzathine penicillin G intramuscularly once or cefixime 400 mg orally t...
Source: Trials - December 9, 2020 Category: Research Source Type: clinical trials
Penicillin Allergy Testing in STD Clinics
Condition: Penicillin Allergy Interventions: Drug: Penicillin Major Determinant (PrePen) Skin Testing; Drug: Direct Oral challenge Sponsors: Johns Hopkins University; Indiana University School of Medicine; Wake Forest University Health Sciences; Louisiana State University Health Sciences Center in New Orleans; University of Washington Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2020 Category: Research Source Type: clinical trials
