A Phase II Study of SBRT Followed by Neoadjuvant Chemoimmunotherapy of Sindilizumab Plus Docetaxel and Cisplatin for Locoregionally Advanced Squamous Carcinoma of Oral Cavity and Oropharynx
Conditions: SBRT Interventions: Combination Product: SBRT+chemoimmunotherapy Sponsors: Sun Yat-sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 23, 2024 Category: Research Source Type: clinical trials

CompARE: study protocol for a phase III randomised controlled platform trial comparing alternative regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer
DiscussionCompARE is designed to be efficient and cost-effective in response to new data, emerging new treatments or difficulties, with the aim of bringing new treatment options for these patients.Trial registrationISRCTNISRCTN41478539. Registered on 29 April 2015 (Source: Trials)
Source: Trials - January 15, 2024 Category: Research Source Type: clinical trials

Validity of Viome's Oral/Throat Cancer Test
Conditions: Oral and Throat Cancer; Oropharyngeal Squamous Cell Carcinoma; Oral Squamous Cell Carcinoma Interventions: Device: Oral/Throat cancer test Sponsors: Viome Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 18, 2023 Category: Research Source Type: clinical trials

Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)
Conditions: Oropharyngeal Neoplasms; Robotic Surgery and/or Radiotherapy; Lymphoscintigraphy Interventions: Radiation: Arm 1- Ipsilateral Sponsors: M.D. Anderson Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 12, 2023 Category: Research Source Type: clinical trials

PD-1 Inhibitor Based Induction Chemotherapy Followed by De-escalation Protocols in OPSCC
Conditions: Oropharyngeal Cancer Interventions: Procedure: Toxicities reduced treatment; Procedure: Conventional treatment Sponsors: Fudan University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 5, 2023 Category: Research Source Type: clinical trials

A New Mutational and Epigenetic Signature to Predict Early OPSCC Relapse
Conditions: Oropharyngeal Squamous Cell Carcinoma Sponsors: Centro di Riferimento Oncologico - Aviano Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 18, 2023 Category: Research Source Type: clinical trials

Standard Pulsed Radiofrequency Versus Supervoltage Pulsed Radiofrequency Glossopharyngeal Nerve in Oropharyngeal Cancer Pain
Conditions: Pulsed Radiofrequency; Super Voltage Pulsed Radiofrequency; Glossopharyngeal Nerve; Oropharyngeal Cancer; Pain Interventions: Procedure: Supervoltage pulsed radiofrequency glossopharyngeal nerve block; Procedure: Standard voltage pulsed radiofrequency glossopharyngeal nerve block Sponsors: National Cancer Institute, Egypt Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 7, 2023 Category: Research Source Type: clinical trials

Prospective Assessment of HPV Associated Anogenital Pathology in Female Patients and Female Partners of Patients With Confirmed HPV Associated Oropharyngeal Carcinoma, PAP-OP Study
Conditions: Oropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma Interventions: Other: Non-Interventional Study Sponsors: Mayo Clinic Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 3, 2023 Category: Research Source Type: clinical trials

Prospective Clinical Study to Assess the Safety and Efficacy of Versius, in Transoral Robotic Surgery
Conditions: Squamous Cell Carcinoma of the Oropharynx; Squamous Cell Carcinoma, Unknown Primary Interventions: Device: Versius Surgical System Sponsors: CMR Surgical Ltd; Liverpool University Hospitals NHS Foundation Trust; Sintesi Research S.r.l. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 1, 2023 Category: Research Source Type: clinical trials

Real-time Targeted Fluorescence Endoscopy for Detection of the Primary Cancer Lesion in Patients With a Metastasis of Unknown Primary Tumor in the Head and Neck
Conditions: Unknown Primary Tumors; Oropharynx Cancer Interventions: Diagnostic Test: Detection of lesions using fluorescence molecular imaging Sponsors: University Medical Center Groningen Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials

New Prognostic and Predictive Biomarkers for HPV-associated Oropharyngeal Cancer
Conditions: PREDICTIVE BIOMARKERS; Evaluation of HPV-specific E5 Transcript Expression in a Cohort of Patients With HPV-associated OPC; HPV 16 Positive Oropharyngeal Tumors (OPC) Interventions: Diagnostic Test: HPV-ASSOCIATED OROPHARYNGEAL CANCER Sponsors: Regina Elena Cancer Institute; University of California, San Diego; Lega Italiana per la Lotta contro i Tumori Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 24, 2023 Category: Research Source Type: clinical trials

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)
Conditions: Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Oropharynx Cancer; Oropharynx Squamous Cell Carcinoma; HPV Positive Oropharyngeal Squamous Cell Carcinoma Interventions: Other: Experimental Observation; Other: Observation per Standard of Care; Radiation: Adjuvant Treatment per Standard of Care; Diagnostic Test: Circulating Tumor DNA test (ctDNA test) Sponsors: University of Maryland, Baltimore Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 18, 2023 Category: Research Source Type: clinical trials

A Window of Opportunity Study of Black Raspberry for Patients With HNSCC
Conditions: Squamous Cell Carcinoma of the Oral Cavity or Oropharynx Interventions: Drug: Black Raspberry Sponsors: Mitchell Machtay Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 17, 2023 Category: Research Source Type: clinical trials

Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer
Conditions: Head and Neck Squamous Cell Carcinoma; Hypopharyngeal Squamous Cell Carcinoma; Laryngeal Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma; Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Lip and Oral Cavity Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Lip and Or...
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials

The Efficacy and Safety of the COMBO Endoscopy Oropharyngeal Airway in Gastrointestinal Endoscopy Procedure
Conditions: Hypoxia; Gastric Polyp; Colon Cancer; Esophageal Cancer Interventions: Device: the COMBO Endoscopy Oropharyngeal Airway; Device: Regular Nasal Cannula Sponsors: RenJi Hospital; Tianjin Medical University General Hospital; The First Affiliated Hospital with Nanjing Medical University; First Affiliated Hospital Xi ' an Jiaotong University; Qianfoshan Hospital; Fudan University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 13, 2023 Category: Research Source Type: clinical trials