Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome
Conditions: Squamous Cell Carcinoma of the Oral Cavity; Squamous Cell Carcinoma of the Oropharynx; Squamous Cell Carcinoma of the Hypopharynx; Squamous Cell Carcinoma of the Larynx Interventions: Other: data collection Sponsors: AIO-Studien-gGmbH; Merck Sharp& Dohme LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 24, 2024 Category: Research Source Type: clinical trials

Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer
Conditions: Oropharyngeal Squamous Cell Carcinoma; Human Papillomavirus Infection Interventions: Genetic: Pre-Radiation Dental Evaluation/Sample Collection; Other: Pre-Study Visit; Genetic: Oral Medicine Consultation Visit/Sample Collection Sponsors: Wake Forest University Health Sciences; InnoTech Precision Medicine Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials

Oropharynx (OPX) Biomarker Trial
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Metastatic Oropharyngeal Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma; Recurrent Oropharyngeal Squamous Cell Carcinoma; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Interventions: Other: Non-Interventional Study Sponsors: Mayo Clinic Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 10, 2024 Category: Research Source Type: clinical trials

Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer
Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Oropharyngeal Squamous Cell Carcinoma Interventions: Procedure: Biospecimen Collection; Drug: Carboplatin; Drug: Cisplatin; Procedure: Computed Tomography; Radiation: External Beam Radiation Therapy; Drug: Paclitaxel; Procedure: Positron Emission Tomography; Other: Questionnaire Administration Sponsors: Ohio State University Comprehensive Cancer Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 21, 2024 Category: Research Source Type: clinical trials

A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer
Conditions: HPV-Related Cervical Carcinoma; HPV Positive Oropharyngeal Squamous Cell Carcinoma Interventions: Drug: Two IM injections Lenti-HPV-07; Drug: One IM injection Lenti-HPV-07 Sponsors: Theravectys S.A. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials

Ex Vivo 3D-ultrasound for Oropharyngeal Cancer
Conditions: Oropharyngeal Squamous Cell Carcinoma Interventions: Diagnostic Test: Ultrasound Sponsors: Rigshospitalet, Denmark Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials

Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly
Conditions: Oropharynx Cancer; Frailty Interventions: Radiation: Modified dose and fields intensity modulated radiotherapy Sponsors: Omar Mahmoud Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 13, 2024 Category: Research Source Type: clinical trials

Comparative Study of New Classification and Traditional Classification of Radioactive Oropharyngeal Mucositis
Conditions: Head and Neck Cancer; Radiation-Induced Mucositis Sponsors: Nanfang Hospital, Southern Medical University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)
Conditions: HPV-Related Oropharyngeal Cancer Interventions: Diagnostic Test: combined HPV 16 DNA and host gene methylation oral biomarker panel Sponsors: H. Lee Moffitt Cancer Center and Research Institute; National Institutes of Health (NIH) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials

De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE)
Conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma Interventions: Radiation: De-escalation; Radiation: Standard of care Sponsors: Royal North Shore Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 12, 2024 Category: Research Source Type: clinical trials

Application of FDG Combined With FAPI PET Dual Imaging in the Diagnosis and Staging of Oropharyngeal and Laryngeal Cancer
Conditions: Cancer Interventions: Diagnostic Test: Diagnostic efficacy,SUV Sponsors: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 11, 2024 Category: Research Source Type: clinical trials

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia
Conditions: Oropharynx Cancer; Head and Neck Cancer; Xerostomia Interventions: Radiation: standard radiotherapy; Radiation: experimental radiotherapy Sponsors: UNC Lineberger Comprehensive Cancer Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 26, 2024 Category: Research Source Type: clinical trials

Pre-operative Atezolizumab in Patients With Resectable, Human Papillomavirus Related Oropharyngeal Carcinoma
Conditions: Oropharynx Cancer, Stage I Interventions: Biological: Atezolizumab; Procedure: Transoral Surgery with cervical lymphadenctomy (neck dissection); Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging Sponsors: Emory University; National Cancer Institute (NCI); Genentech, Inc. Suspended (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials

Trial of Individualized Adaptive RT in HPV-related High Risk Oropharynx Cancer
Conditions: Oropharynx Cancer; HPV-Related Carcinoma Interventions: Radiation: Radiation; Drug: Platinum based chemotherapy Sponsors: University of Michigan Rogel Cancer Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 31, 2024 Category: Research Source Type: clinical trials

Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer
Conditions: Squamous Cell Carcinoma of the Head and Neck; Oropharynx; Human Papillomavirus Viruses; Drug Therapy; Cancer Vaccine Interventions: Drug: Docetaxel; Drug: Cisplatin; Drug: PRGN-2009 Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 25, 2024 Category: Research Source Type: clinical trials