Retrospective Study of Airway Management in Dutch ED's
Conditions: Endotracheal Intubation Interventions: Procedure: Endotracheal intubation Sponsors: Medical Centre Leeuwarden; VieCuri Medical Centre; Catharina Ziekenhuis Eindhoven; Rijnstate Hospital; Zuyderland Medical Centre Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials

Longevity Families of the Netherlands
Conditions: Longevity; Familial Longevity; Extreme Longevity; Aging Sponsors: Leiden University Medical Center; Jacobijn Gussekloo, Prof. dr.; Simon P. Mooijaart, Prof. dr. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 18, 2024 Category: Research Source Type: clinical trials

Prediction Models for Complications After CRT in Esophageal Cancer
Conditions: The Aim of This Project is to Develop and Validate NTCP-models for Complications After nCRT (and Surgical Resection) Interventions: Other: retrospective Sponsors: University Medical Center Groningen; Dutch Cancer Society; Comprehensive Cancer Centre The Netherlands; Dutch Institute for Clinical Auditing (DICA); ZorgTTP Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 16, 2024 Category: Research Source Type: clinical trials

UK ANDROMEDA-Shock-2 RCT
Conditions: Septic Shock Interventions: Procedure: Personalised fluid and haemodynamic resuscitation Sponsors: Guy ' s and St Thomas ' NHS Foundation Trust; Pontificia Universidad Catolica de Chile; University of Rotterdam, The Netherlands Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 16, 2024 Category: Research Source Type: clinical trials

CARE1 Pragmatic Clinical Trial
Conditions: Metastatic Kidney Cancer; Metastatic Kidney Carcinoma Interventions: Drug: Nivolumab; Drug: Ipilimumab; Drug: Pembrolizumab; Drug: Cabozantinib; Drug: Axitinib; Drug: Lenvatinib Sponsors: Gustave Roussy, Cancer Campus, Grand Paris; European Commission; CRIS Cancer Foundation; National Cancer Institute, France; Rennes University Hospital; University Hospital, Essen; Fundaci ó Privada Institut d ' Investigaci ó Oncològica de Vall d ' Hebron; The Netherlands Cancer Institute; Servicio Madrile ño de Salud, Madrid, Spain; Hospital Universitario 12 de Octubre; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan...
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials

#Chatsafe Netherlands: a Social Media Intervention to Improve Dutch Young People's Safe Communication About Suicide Online
Conditions: Suicide Prevention; Communication; Social Media Interventions: Behavioral: Social Media campaign Sponsors: 113 Suicide Prevention; Orygen; Mind Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials

The (cost-)effectiveness of early intervention (MBT-early) versus standard protocolized treatment (CBT) for emerging borderline personality disorder in adolescents (the EARLY study): a study protocol for a randomized controlled trial
This study is a multi-centre randomized controlled trial. A total of 132 adolescents, presenting with either depression, anxiety, or both and significant BPD features will be randomized to either MBT-early or CBT. The severity of BPD, symptoms of depression and anxiety, personality, social and academic functioning, and quality of life will be assessed at baseline, end of treatment, and at 12-, 18-, and 24-month follow-up, along with medical costs and costs of productivity losses for cost-effectiveness analyses.DiscussionThis study will provide an empirical evaluation of the potential surplus value of early intervention in ...
Source: Trials - April 15, 2024 Category: Research Source Type: clinical trials

Preoperative Accelerated Partial Breast Irradiation in Patients With Locally Recurrent or Second Primary Breast Cancer
Conditions: Breast Cancer Interventions: Radiation: Preoperative accelerated partial breast irradiation; Procedure: Breast conserving surgery; Procedure: Sentinel node procedure; Procedure: Biopsy track removal Sponsors: The Netherlands Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials

Gaining Insight Into Dual Sensory Loss
Conditions: Dual Sensory Impairment of Vision and Hearing Sponsors: Amsterdam UMC, location VUmc; Royal Dutch Visio Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials

RISEinFAMILY project: the integration of families at neonatal intensive care units (NICUs) to empower them as primary caregivers: study protocol for a stepped wedge cluster controlled trial
This study aims to evaluate the scalability and adaptation of FICare across a broader range of geographical and sociocultural contexts and address its sustainability. Furthermore, it seeks to compare the RISEinFAMILY model with standard care, examining differences in short-term newborn outcomes, family mental health, and professional satisfaction.Trial registrationClinicalTrials.gov NCT06087666. Registered on 17 October 2023. Protocol version: 19 December 2022; version 2.2. (Source: Trials)
Source: Trials - April 10, 2024 Category: Research Source Type: clinical trials

Carboplatin/Paclitaxel + Pembrolizumab for Locoregionally Advanced Penile Cancer
Conditions: Urologic Neoplasms; Urogenital Neoplasms; Male Urogenital Diseases; Penile Cancer; Penile Squamous Cell Carcinoma; Locally Advanced Penile Carcinoma Interventions: Drug: Carboplatin/Paclitaxel; Drug: Pembrolizumab; Procedure: Partial or total penectomy with inguinal and/or pelvic lymph node dissection Sponsors: The Netherlands Cancer Institute; Merck Sharp& Dohme LLC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 9, 2024 Category: Research Source Type: clinical trials

Intervention Social Anxiety: Combining Parent-child Treatment
Conditions: Social Anxiety Disorder of Childhood Interventions: Other: Denken + Doen = Durven; Other: Supportive Parenting for Anxious Childhood Emotions Sponsors: Leiden University; Leids Universitair Behandel en Expertise Centrum (LUBEC); GGZ Delfland; Netherlands Organisation for Scientific Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 8, 2024 Category: Research Source Type: clinical trials

Dutch CHolEcystitis Snapshot Study
Conditions: Cholecystitis; Cholecystitis; Gallstone; Cholecystitis; Choledocholithiasis Sponsors: St. Antonius Hospital; St. Antonius Onderzoeksfonds; Dutch Snapshot Research Grpup; Nederlandse Leverpatientenvereniging Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 5, 2024 Category: Research Source Type: clinical trials

Robotic Subretinal tPA Injection Study
Conditions: Subretinal Hemorrhage; Age-Related Macular Degeneration Interventions: Device: Robotic subretinal tPA injection Sponsors: Universitaire Ziekenhuizen KU Leuven; DORC Dutch Ophthalmic Research Center International BV Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 4, 2024 Category: Research Source Type: clinical trials

Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema
Conditions: Hereditary Angioedema; Hereditary Angioedema Type I; Hereditary Angioedema Type II; Hereditary Angioedema Types I and II; Hereditary Angioedema Attack; Hereditary Angioedema With C1 Esterase Inhibitor Deficiency; Hereditary Angioedema - Type 1; Hereditary Angioedema - Type 2; C1 Esterase Inhibitor [C1-INH] Deficiency; C1 Esterase Inhibitor Deficiency; C1 Esterase Inhibitor, Deficiency of; C1 Inhibitor Deficiency Interventions: Drug: Deucrictibant, Placebo Sponsors: Pharvaris Netherlands B.V. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 3, 2024 Category: Research Source Type: clinical trials