Neoadjuvant Radiation Therapy Forums This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Breast RNI and IMN coverage Discussion.... Again. Breast is the worst x 4?
New breast is the worst case. Just saw a 39 yo with a BRCA mutation who had what was called a cT2N2 ER+ PR-/HER2- breast cancer. This was in the setting of a biopsied 4.6 cm primary and an MRI with 7 abnormal-appearing axillary nodes, none of which were biopsied. Got neoadjuvant chemo followed by lumpectomy and ax dissection. Final staging was ypT1aN0. Residual primary was 1.5 mm with treatment effect noted. 0/17 nodes with no treatment effect noted. For reference, an abnormal node... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - April 3, 2024 Category: Universities & Medical Training Authors: Ray D. Ayshun Tags: Radiation Oncology Source Type: forums

Retroperitoneal sarcoma delineation
Hello! I have a question concerning the delineation of a retroperitoneal sarcoma. This patient has a dedifferentiated RPS, the biopsy was performed in the solid mass in the upper left abdomen. It's a high-grade liposarcoma, not metastatic. However, as you can see, there is a considerable mass, which likely represents well differentiated sarcoma, reaching very far into the pelvis. Neoadjuvant treatment is planned with chemo + RT, followed by surgery. Would any of you... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - March 21, 2024 Category: Universities & Medical Training Authors: Palex80 Tags: Radiation Oncology Source Type: forums

Thoughts?
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages Iâ€“III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial - Nature Communications The authors previously reported the primary outcomes of a randomized phase II trial comparing neoadjuvant durvalumab (anti-PD-L1) alone or in combination with stereotactic radiotherapy in patients with early-stage NSCLC. Here, the authors report the secondary outcomes of the trial and post hoc... www.nature.com (Source: Student Doctor Network)
Source: Student Doctor Network - December 29, 2023 Category: Universities & Medical Training Authors: Lamount Tags: Radiation Oncology Source Type: forums

Photons vs. Protons for Esophageal Cancer
Hey, I wanna hear your feedback on this one. I just found out that this trial is running protecttrial.eu protecttrial.eu A randomized Phase III trial on photons vs. protons for neoadjuvant chemorads in esophageal cancer. The trial will cost roughly 5 million dollars IMI Innovative Medicines Initiative | PROTECT-trial | Proton versus photon therapy for esophageal cancer - a trimodality strategy Radiotherapy plays a key role in the ...
Source: Student Doctor Network - August 23, 2023 Category: Universities & Medical Training Authors: Palex80 Tags: Radiation Oncology Source Type: forums

Asco 2023
Abstracts are out. A selection of interesting stuff: LBAs (results pending): https://meetings.asco.org/abstracts-presentations/218388 This is the long awaited late breaking abstract of PEACE-1, testing RT to the prostate for mHSPC. Perhaps confirmation of STAMPEDE Arm-H results, perhaps not. https://meetings.asco.org/abstracts-presentations/219804 Phase III trial on chemo-RT vs. chemo as neoadjuvant treatment of rectal cancer. I have a bad feeling about this... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - May 26, 2023 Category: Universities & Medical Training Authors: Palex80 Tags: Radiation Oncology Source Type: forums

MSI High Rectal Cancer
Has anyone seen the latest NCCN rectal guidelines showing neoadjuvant/definitive immunotherapy for MSI high patients as category 2B recommendation. Does anyone know what data this recommendation is based on? I'm hoping it's not that 12 person study. (Source: Student Doctor Network)
Source: Student Doctor Network - April 19, 2023 Category: Universities & Medical Training Authors: madchemist89 Tags: Radiation Oncology Source Type: forums

when do you use SCRT (25Gy/5fr) within a total neoadjuvant approach for Rectal Ca?
Dear Colleagues, I am interested to know when do you favor standard LCRT versus SCRT in the setting of a TNT approach for rectal cancer? What are the criterias you follow ? does the age matter (young versus elderly)? location (lower/upper rectum)? sphincter involvement? sequencing (induction chemo versus upfront RT)? Any other considerations? ty a lot for sharing your thoughts (Source: Student Doctor Network)
Source: Student Doctor Network - November 29, 2022 Category: Universities & Medical Training Authors: Kroll2013 Tags: Radiation Oncology Source Type: forums

Lutetium Psma localized prostate cance
Anyone know the status of trials for lutetium Psma in localized prostate cancer either alone or neoadjuvant to surgery. Could really transform the specialty if it pans out. How about lutetium vs as? Lutetium-PSMA Appears Safe in Locally Advanced High-Risk Prostate Cancer Treatment with neoadjuvant lutetium prostate-specific membrane antigen followed by radical prostatectomy exhibited a favorable safety profile in patients with locally advanced high-risk prostate cancer. www.onclive.com (Source: Student Doctor Network)
Source: Student Doctor Network - June 22, 2022 Category: Universities & Medical Training Authors: RickyScott Tags: Radiation Oncology Source Type: forums

Neoadjuvant FLOT/MAGIC vs. CROSS in Distal Esophageal
I'm at a major academic center and the other day it was suggested that we should start considering neoadjuvant chemo alone for distal esophageal cancers based on this abstract at ASCO. Every single reported metric in the table below was superior for CROSS and yet the conclusion was "the data strongly suggests non-inferiority and equipoise." When us doom and gloomers talk about the declining indications for radiation it's because of things like this. We're perpetually one successful chemo... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - March 31, 2022 Category: Universities & Medical Training Authors: RSAOaky Tags: Radiation Oncology Source Type: forums

PREOPANC Discussion
Can a GI specialist decipher this for me? Big wig med onc at MDACC. At first it seemed to me he was speaking positively about neoadjuvant chemoRT, but then in his reply to a commenter it seems like maybe I misinterpreted? (Source: Student Doctor Network)
Source: Student Doctor Network - February 1, 2022 Category: Universities & Medical Training Authors: Krukenberg Tags: Radiation Oncology Source Type: forums

CROSS regimen on the chopping block
Tried to see if this was limited to Siewert II/III but seems all locations allowed: NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS) - Full Text View - ClinicalTrials.gov So periop chemo may become an option now for esophagus… (Source: Student Doctor Network)
Source: Student Doctor Network - June 6, 2021 Category: Universities & Medical Training Authors: frijoles Tags: Radiation Oncology Source Type: forums

What after neoadjuvant CT-RT for Lung Ca that remained inoperable?
Dear Colleagues, I hope you are safe. I need your advice concerning my patient 65 years old, who initially presented (at another institution) for a left lung para-hilar mass, 5cm, involving the left lingular bronchi, N2 on Pet, M0. Biopsy: Poorly differentiated NSCLC, EGFR neg, ALK neg, PD-L1 90% He received neo-adjuvant CT (CDDP-Navelbine) + RT 45Gy/25fr. He had a partial response but still inoperable. Last RT session was on october 26/10/20. What to do ? Do you recommend SBRT to the... Read more (Source: Student Doctor Network)
Source: Student Doctor Network - January 28, 2021 Category: Universities & Medical Training Authors: Kroll2013 Tags: Radiation Oncology Source Type: forums

Triple Neg with residual post neoadjuvant....
.... med onc wants to give Xeloda during radiation. Are you hypofractionating or standard fractionation? (Source: Student Doctor Network)
Source: Student Doctor Network - January 28, 2021 Category: Universities & Medical Training Authors: Mandelin Rain Tags: Radiation Oncology Source Type: forums

Nodal ITC after neoadjuvant chemotherapy
Dear colleagues, I would greatly appreciate your input on this situation. cT2N0 triple positive breast cancer. Mastectomy and axillary clearance after neoadjuvant chemotherapy shows pCR in the breast and sentinel node biopsy shows ITC. RT? Leave alone? Thanks (Source: Student Doctor Network)
Source: Student Doctor Network - October 5, 2020 Category: Universities & Medical Training Authors: Treat Tags: Radiation Oncology Source Type: forums

Breast Case
41 y/o female, 6cm IDC, 2 enlarged axillary lymph nodes on preop imaging (2cm and 1.5cm respectively), IDC, ER 10%, PR/HER-2-negative. 2cm axillary node core biopsy negative (clip placed at time of biopsy). BRCA-negative. Received neoadjuvant ACT with imaging showing complete resolution of breast mass and "normalization" of both enlarged nodes. (Per imaging, the 1.5 cm node initially showed thickened cortex but now normalized with fatty hilum). Got simple mastectomy + SLNB + immediate... Breast Case (Source: Student Doctor Network)
Source: Student Doctor Network - May 29, 2020 Category: Universities & Medical Training Authors: Reaganite Tags: Radiation Oncology Source Type: forums