Association between microsatellite status and characteristics and outcomes of early-onset compared to late-onset rectal cancer
ConclusionsIn both age groups, MSI-H rectal cancers were more often mucinous and poorly differentiated carcinomas and had pT3-4 stage more often than MSS cancers. MSI-H rectal cancers tend to present less often with distant metastases and nodal involvement than MSS cancers only in early-onset, but not in late-onset rectal cancers. The association between MSI status and survival was not notable in this study, whether in the early-onset or late-onset groups. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - March 28, 2024 Category: Gastroenterology Source Type: research

Timing of Surgery and Social Determinants of Health Related to Pathologic Complete Response after Total Neoadjuvant Therapy for Rectal Adenocarcinoma: Retrospective Study of National Cancer Database
This study utilized the National Cancer Database (NCDB) to retrospectively analyze 5997 stage-appropriate RAC cases treated with TNT from 2016 to 2020. The overall pCR rate was 18.6%, with most patients undergoing induction chemotherapy followed by long-course chemoradiation (81.5%). Multivariable logistic regression models revealed a significant non-linear relationship between the rest period and pCR (p = 0.033), with optimal odds at 14.7-15.9 weeks post radiation (odds ratio: 1.49, 95% confidence interval: 1.13-1.98) when compared to 4.0 weeks. Medicaid, distance to the treatment facility, and community education were as...
Source: Current Oncology - March 27, 2024 Category: Cancer & Oncology Authors: Megan Mai Jodi Goldman Duke Appiah Ramzi Abdulrahman John Kidwell Zheng Shi Source Type: research

A review of perioperative treatment strategies with immunotherapy and tyrosine kinase inhibitors in resectable and stage IIIA-N2 non-small cell lung cancer
Stage IIIA-N2 non-small cell lung cancer (NSCLC) is a heterogeneous group with different potential therapeutic approaches. Treatment is typically multimodal with either surgical resection after neoadjuvant chemotherapy and/or radiation or concurrent chemotherapy and radiation if unresectable. Despite the multimodal treatment and early stage, cure rates have traditionally been low. The introduction of immunotherapy changed the treatment landscape for NSCLC in all stages, and the introduction of immunotherapy in early-stage lung cancer has improved event free survival and overall survival. Tyrosine Kinase inhibitors (TKIs) h...
Source: Frontiers in Oncology - March 27, 2024 Category: Cancer & Oncology Source Type: research

Comparison of clinical characteristics between ACOSOG Z0011-eligible cohort and sentinel lymph node-positive breast cancer patients in Hong Kong
CONCLUSION: This study demonstrated that clinicopathological features were comparable between SLN-positive breast cancer patients undergoing mastectomy and those undergoing breast-conserving treatment. Low-risk SLN-positive mastectomy patients may safely avoid completion axillary lymph node dissection.PMID:38523397 | DOI:10.12809/hkmj2210286 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - March 25, 2024 Category: General Medicine Authors: V Man A Kwong Source Type: research

Comparison of clinical characteristics between ACOSOG Z0011-eligible cohort and sentinel lymph node-positive breast cancer patients in Hong Kong
CONCLUSION: This study demonstrated that clinicopathological features were comparable between SLN-positive breast cancer patients undergoing mastectomy and those undergoing breast-conserving treatment. Low-risk SLN-positive mastectomy patients may safely avoid completion axillary lymph node dissection.PMID:38523397 | DOI:10.12809/hkmj2210286 (Source: Hong Kong Med J)
Source: Hong Kong Med J - March 25, 2024 Category: General Medicine Authors: V Man A Kwong Source Type: research

Comparison of clinical characteristics between ACOSOG Z0011-eligible cohort and sentinel lymph node-positive breast cancer patients in Hong Kong
CONCLUSION: This study demonstrated that clinicopathological features were comparable between SLN-positive breast cancer patients undergoing mastectomy and those undergoing breast-conserving treatment. Low-risk SLN-positive mastectomy patients may safely avoid completion axillary lymph node dissection.PMID:38523397 | DOI:10.12809/hkmj2210286 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - March 25, 2024 Category: General Medicine Authors: V Man A Kwong Source Type: research

Comparison of clinical characteristics between ACOSOG Z0011-eligible cohort and sentinel lymph node-positive breast cancer patients in Hong Kong
CONCLUSION: This study demonstrated that clinicopathological features were comparable between SLN-positive breast cancer patients undergoing mastectomy and those undergoing breast-conserving treatment. Low-risk SLN-positive mastectomy patients may safely avoid completion axillary lymph node dissection.PMID:38523397 | DOI:10.12809/hkmj2210286 (Source: Hong Kong Med J)
Source: Hong Kong Med J - March 25, 2024 Category: General Medicine Authors: V Man A Kwong Source Type: research

Role of Oxaliplatin in the Neoadjuvant Concurrent Chemoradiotherapy in Locally Advanced Rectal Cancer: a Review of Evidence
Clin Med Insights Oncol. 2024 Mar 19;18:11795549241236409. doi: 10.1177/11795549241236409. eCollection 2024.ABSTRACTThe treatment of locally advanced rectal cancer (LARC) is a challenging situation for radiation oncologists and colorectal surgeons. Most current approaches recommend neoadjuvant fluorouracil or capecitabine-based chemoradiotherapy followed by surgery as a standard of care. Intensification of concurrent chemotherapy by adding oxaliplatin to fluorouracil or capecitabine backbone to get better outcomes is the matter that has remained unresolved. In this review, we searched Medline and Google Scholar databases a...
Source: Clinical Colorectal Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Reza Nazari Guglielmo Niccol ò Piozzi Reza Ghalehtaki Seyed Mohsen Ahmadi-Tafti Behnam Behboudi Nima Mousavi Darzikolaee Mahdi Aghili Maria Antonietta Gambacorta Source Type: research

Role of Oxaliplatin in the Neoadjuvant Concurrent Chemoradiotherapy in Locally Advanced Rectal Cancer: a Review of Evidence
Clin Med Insights Oncol. 2024 Mar 19;18:11795549241236409. doi: 10.1177/11795549241236409. eCollection 2024.ABSTRACTThe treatment of locally advanced rectal cancer (LARC) is a challenging situation for radiation oncologists and colorectal surgeons. Most current approaches recommend neoadjuvant fluorouracil or capecitabine-based chemoradiotherapy followed by surgery as a standard of care. Intensification of concurrent chemotherapy by adding oxaliplatin to fluorouracil or capecitabine backbone to get better outcomes is the matter that has remained unresolved. In this review, we searched Medline and Google Scholar databases a...
Source: Clinical Colorectal Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Reza Nazari Guglielmo Niccol ò Piozzi Reza Ghalehtaki Seyed Mohsen Ahmadi-Tafti Behnam Behboudi Nima Mousavi Darzikolaee Mahdi Aghili Maria Antonietta Gambacorta Source Type: research

CDKL3 shapes immunosuppressive tumor microenvironment and initiates autophagy in esophageal cancer
ConclusionCDKL3 may play an important role in anti-tumor immunity by regulating autophagy to promote the formation of immunosuppressive TME, thus playing a critical role in the prognosis of ESCA. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 18, 2024 Category: Allergy & Immunology Source Type: research

A Randomized Trial Comparing Quality of Life After LDR or HDR Prostate Brachytherapy Boost with Pelvic External Beam Radiation Therapy
CONCLUSIONS: Patient experience for combined EBRT and prostate BT is improved with HDR BT. Urinary QoL improves over time to be equivalent between the 2 modalities after 18 months, but LDR patients report lasting bowel symptoms.PMID:38493901 | DOI:10.1016/j.ijrobp.2024.02.064 (Source: Health Physics)
Source: Health Physics - March 17, 2024 Category: Physics Authors: Juanita Crook Nikitha Moideen Greg Arbour Felipe Castro C ánovas Cynthia Araujo Deidre Batchelar Ross Halperin Michelle Hilts David Kim David Petrik Jim Rose J C Cheng Francois Bachand Source Type: research

Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the pancreas
CONCLUSION: Despite rigorous QA, we encountered variability in simulation, contouring, plan coverage, and dose on trial. While clinical outcomes did not appear to be impacted, findings from this analysis serve to inform subsequent PDAC SBRT trial designs and QA requirements.PMID:38492812 | DOI:10.1016/j.ijrobp.2024.03.013 (Source: Health Physics)
Source: Health Physics - March 16, 2024 Category: Physics Authors: Leila T Tchelebi Diana Segovia Koren Smith Qian Shi T J Fitzgerald Michael D Chuong Tyler J Zemla Eileen M O'Reilly Jeffrey Meyerhardt Eugene J Koay Jessica Leif Ardaman Shergill Matthew Hg Katz Joseph M Herman Source Type: research

Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the pancreas
CONCLUSION: Despite rigorous QA, we encountered variability in simulation, contouring, plan coverage, and dose on trial. While clinical outcomes did not appear to be impacted, findings from this analysis serve to inform subsequent PDAC SBRT trial designs and QA requirements.PMID:38492812 | DOI:10.1016/j.ijrobp.2024.03.013 (Source: Health Physics)
Source: Health Physics - March 16, 2024 Category: Physics Authors: Leila T Tchelebi Diana Segovia Koren Smith Qian Shi T J Fitzgerald Michael D Chuong Tyler J Zemla Eileen M O'Reilly Jeffrey Meyerhardt Eugene J Koay Jessica Leif Ardaman Shergill Matthew Hg Katz Joseph M Herman Source Type: research

Evaluating persistent T1-weighted lesions without concurrent abnormal enhancement on breast MRI in neoadjuvant chemotherapy patients: implications for complete pathological response
ConclusionPersistent T1-weighted lesions without associated abnormal enhancement on post-treatment breast MRI correlate with lower complete pathological and imaging response rates.Clinical relevance statementThe study underscores the importance of persistent T1-weighted lesions on breast MRI as vital clinical markers, being inversely related to a complete pathological response following neoadjuvant chemotherapy; they should be a key factor in guiding post-neoadjuvant chemotherapy treatment decisions.Key Points•Persistent T1 lesions on post-chemotherapy breast MRI indicate a reduced likelihood of achieving a complete path...
Source: European Radiology - March 16, 2024 Category: Radiology Source Type: research

The Microbiome is Associated with Responses to Neoadjuvant Therapy in Primary Nasopharyngeal Carcinoma
The microbiome has been noted to be altered in a variety of malignancies including nasopharyngeal carcinoma (NPC). Microbiome dysbiosis is postulated to affect the tumor immune microenvironment and potentially responses to radiotherapy, chemotherapy and immunotherapy. Here we sought to elucidate the role of the microbiome in predicting responses to neoadjuvant therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: J. Chan, J. Chen, D. Yeung, Z. Chen Tags: 238 Source Type: research