New technique for testing drugs to treat cystic fibrosis and epilepsy
Researchers from the University of Southampton, in collaboration with researchers at the University of Quebec at Montreal, have developed a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy.A large percentage of pharmaceutical drugs target ion channels, which are proteins found in a cell's membrane, that play a pivotal role in these serious disorders and that are used to test the effectiveness of new drugs. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 30, 2013 Category: Consumer Health News Tags: Pharma Industry / Biotech Industry Source Type: news
Discovery of most common cause of muscle-weakening disease myasthenia gravis
An antibody to a protein critical to enabling the brain to talk to muscles has been identified as a cause of myasthenia gravis, researchers report. The finding that an antibody to LRP4 is a cause of the most common disease affecting brain-muscle interaction helps explain why as many as 10 percent of patients have classic symptoms, like drooping eyelids and generalized muscle weakness, yet their blood provides no clue of the cause, said Dr. Lin Mei, Director of the Institute of Molecular Medicine and Genetics at the Medical College of Georgia at Georgia Regents University... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 13, 2013 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news
New cause found for muscle-weakening disease myasthenia gravis
(Medical College of Georgia at Georgia Regents University) An antibody to a protein critical to enabling the brain to talk to muscles has been identified as a cause of myasthenia gravis, researchers report. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 11, 2013 Category: Global & Universal Source Type: news
JCI early table of contents for Nov. 8, 2013
(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, Nov., 8, 2013, in the JCI: Ion channel inhibition limits injury-induced loss of kidney filtration, Researchers identify a histone demethylase associated with non-small cell lung cancer,Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis, Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy, Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma, and more....
Source: EurekAlert! - Medicine and Health - November 8, 2013 Category: Global & Universal Source Type: news
Late-Onset Myasthenia Gravis Linked to Higher Cancer RiskLate-Onset Myasthenia Gravis Linked to Higher Cancer Risk
Myasthenia gravis, especially if it is of late onset, carries a high risk for cancers outside of the thymus. These malignancies were of heterogeneous origin, and all were solid tumors, a study shows. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 3, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Myasthenia Gravis May Follow Infection by West Nile VirusMyasthenia Gravis May Follow Infection by West Nile Virus
West Nile virus infection is now linked to myasthenia gravis months later, case reports indicate. Residual deficits, such as weakness or fatigue, may confound or delay the myasthenia gravis diagnosis. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 2, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
How Often Does Clubfoot Recur?
Discussion
Newborn foot deformities are relatively common with an incidence of ~4.2%. About 75% of these are due to metatarsus adductus. Talipes equinovarus, calcaneovulgus foot and vertical talus are the other most common abnormalities.
Congenital talipes equinovarus or clubfoot deformity occurs in 1-2/1000 births. The mneumonic CAVE identifies the major findings of Cavus, forefoot Adduction, hindfoot Varus and Equinus. Clubfoot can be mild to severe with the more severe forms being associated with other problems.
The Ponseti method is currently considered the main treatment method with better short-term outcomes compa...
Source: PediatricEducation.org - May 6, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Tirasemtiv: Initial Promise in Myasthenia Gravis Tirasemtiv: Initial Promise in Myasthenia Gravis
Results of a pilot trial suggest that the drug, which is also being studied in ALS, may improve function in myasthenia gravis. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Fatigue and fatigability in neurologic illnesses: Proposal for a unified taxonomy - Kluger BM, Krupp LB, Enoka RM.
Fatigue is commonly reported in many neurologic illnesses, including multiple sclerosis, Parkinson disease, myasthenia gravis, traumatic brain injury, and stroke. Fatigue contributes substantially to decrements in quality of life and disability in these il... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - January 25, 2013 Category: Global & Universal Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Clinical Review: Myasthenia gravis
The characteristics of myasthenia gravis, key diagnostic features and how to manage this condition, aplus a round up of the current evidence base. (Source: GP Online Education)
Source: GP Online Education - April 29, 2011 Category: Primary Care Tags: Autoimmune disorders Source Type: news
