Assessment of Methadone Dose Taken Using Electrochemistry
Conditions: Methadone Toxicity; Methadone Overdose; Pain, Chronic; Drug Metabolism, Poor, CYP2D6-Related; Metabolism Medication Toxicity Interventions: Device: ISF extraction device 1; Diagnostic Test: Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo; Device: Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo; Drug: Measurement of Methadone in ISF before and after taking prescribed dose; Device: ISF Extraction Device 2 Sponsor: Cari Health Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 8, 2023 Category: Research Source Type: clinical trials
Pragmatic, randomized, blinded trial to shorten pharmacologic treatment of newborns with neonatal opioid withdrawal syndrome (NOWS)
DiscussionThe proposed study is a pragmatic trial to determine whether a rapid-weaning intervention reduces the number of days of opioid treatment, compared to a slow-weaning intervention, and we powered the proposed study to detect a 2-day difference in the length of treatment. Hospitals will be able to use either morphine or methadone with the knowledge that we may find a positive treatment effect for both, one, or neither drugs.Trial registrationNCT04214834. Registered January 2, 2020. (Source: Trials)
Source: Trials - July 21, 2023 Category: Research Source Type: clinical trials
Hyperbaric Oxygen Treatment (HBOT) During Methadone Tapering
Condition: Opioid Use Disorder Interventions: Biological: Hyperbaric Oxygen Treatment Full; Biological: Hyperbaric Oxygen Treatment Partial Sponsor: Washington State University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 29, 2023 Category: Research Source Type: clinical trials
