Fight Aging! Newsletter, May 1st 2017
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation."
In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create molec...
Source: Fight Aging! - April 30, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Evidence for Senescent Cells as a Significant Cause of Osteoarthritis
UNITY Biotechnology has obtained a large amount of venture funding in order to work on senolytic therapies, treatments capable of removing significant numbers of the senescent cells that accumulate with advancing age. Cellular senescence is one of the root cases of aging, as these cells cause inflammation and disruption of tissue structure and function. Enough of them can and will kill you, though the usual mechanism of producing ultimately fatal age-related diseases, assuming that none of the other causes of aging get there first. The UNITY Biotechnology principals initially aim to push senolytics through the regulatory p...
Source: Fight Aging! - April 25, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, April 24th 2017
This study identified 1,497 genes with significantly different expression at different ages. Gene sets with a defined age-associated expression pattern provide information about molecular processes with altered activity during aging and provide a valuable diagnostic tool for determining individual biological rate of aging and predicting risk of age-associated disease, as demonstrated in follow-up analyses. On a gene-by-gene basis, differential expression alone is insufficient to distinguish between genes that play a causative role in aging and genes that merely respond to the altered physiological environment in an aging o...
Source: Fight Aging! - April 23, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
If Much Older than 30, Save More Aggressively Over the Next Decade or Two
The objective for most of us is to make those lines cross sooner rather than later. If you dent your savings in a way that pushes out the achievement of traditional retirement goals by a few years in order to undergo an effective rejuvenation therapy, I think that puts you ahead of the game. Besides, traditional retirement isn't going to look very traditional any more by the time most of the younger folk in the audience get there. The aging of the population ensures that more people will simply remain working because there will be more work to accomplish than young people available to accomplish it. The advent of rejuvenat...
Source: Fight Aging! - April 22, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Some Surgicenters Listing Prices, Reject Insurance, and Require Cash Payment
I have been closely tracking various developments in free-standing clinics and surgicenters that may stumulate a more competitive environment for hospitals (see, for example:Tug of War between Hospitals and Surgicenters for Knee Replacements). I recently blogged about how opaque hospital bills have discouraged many patients (see:Coding for Hospital Services; One Reason for the High Cost of Healthcare). I also posted a note about how some hospitals were providing more price transparency (see:Greater Transparency for Hospital Charges Slowly Becoming the Norm).In order to be more competitiv...
Source: Lab Soft News - April 14, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Healthcare Business Healthcare Delivery Healthcare Insurance Hospital Financial Medical Consumerism Quality of Care Source Type: blogs
Key Mechanisms That Define Health City Cayman Islands ’ Value Innovation
Conclusion
Building on NH’s goal of delivering the highest quality care at the lowest possible cost, HCCI represents a refreshing and potentially highly disruptive approach to globally competitive medicine.
HCCI offers unquestionably high quality care at surprisingly affordable prices, but the model’s marketability is being tested by the US market, which is all but locked in by special interest structures. For example, health plans seeking to make health care cost more, rather than less – net earnings may be a percentage of total expenditures – may see nearshore care as counter to their interests. Brokers m...
Source: The Health Care Blog - April 4, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, April 3rd 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - April 2, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Open Longevity Initiative Works Towards Organization of Trials
I noted the existence of the Open Longevity initiative earlier this month. This is an evolution of the core Russian-language longevity science community, involved in the Science for Life Extension Foundation and related advocacy initiatives. The members of that community have been building bridges to the European and US longevity science communities for a decade now, aided by progress in automated translation technologies and the growing prospects for therapies that can meaningful treat the causes of aging. Collectively, we've reached the point at which meaningful treatments are almost at the clinic; it is the time to move...
Source: Fight Aging! - March 31, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, March 27th 2017
In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes.
The recently established epigenetic clock (DNAm age) has received growing attention as an increasing number of studies have uncovered it to be a proxy of biological ageing and thus potentially providing a measure for assessing health and mortality. Intriguingly, we targeted mortality-related DNAm changes and did not find any overlap with previously established CpGs that are used to determine the DNAm age. Our findings are in line with evidence, suggesting that DNAm involved in ageing or health-related outcomes are mostly...
Source: Fight Aging! - March 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Next for UNITY Biotechnology?
What follows here is an inside baseball discussion relating to the companies working on senolytic therapies, biotechnologies capable of selectively destroying senescent cells. The presence of these cells is one of the causes of aging and age-related disease, and their removal is the first of a number of rejuvenation therapies based on the SENS vision that will emerge over the next few decades. Human trials of the first senolytics will be starting this year and next, and by the mid-2020s most people in the wealthier parts of the world will have the opportunity to remove this part of the burden of aging. This is a wondrous d...
Source: Fight Aging! - March 25, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Methuselah Foundation Launches Methuselah Fund
Those in the audience who have been members of this community for a while will know that the Methuselah Foundation has long acted as a form of incubator for biotechnology startups relevant to healthy life extension. The organization has undertaken this role in addition to funding some of the most promising research efforts in the field, such as the SENS rejuvenation biotechnology projects. This incubator work hasn't involved a large number of startups in total, since we are not yet either a vast or a wealthy community when considered in the grand scheme of things, and it is the case that the Methuselah Foundation is powere...
Source: Fight Aging! - March 22, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
An Open Briefing For the President ’ s Economic Advisors (And Concerned Members of the House & Senate )
By JOE FLOWER
This is a letter I sent to Gary Cohn, appointed by President Trump to head the National Economic Council and, among other things, come up with a plan for reforming healthcare. Formerly president of Goldman Sachs, Cohn may be a wizard at finance, but healthcare economics are wildly different and famously opaque. So I thought I would help him out.]
Subject: A brief on healthcare economics. (8 minutes)
o Why healthcare economics are different.
o Why the ACA is failing.
o What would work.
Who I am (credentials): Independent healthcare author and analyst since Jimmy Carter’s administration. Speaker, consu...
Source: The Health Care Blog - March 10, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Why This Doesn ’ t Actually Work The Way You Think It Does
By JOE FLOWER
This is a letter I sent to Gary Cohn, appointed by President Trump to head the National Economic Council and, among other things, come up with a plan for reforming healthcare. Formerly president of Goldman Sachs, Cohn may be a wizard at finance, but healthcare economics are wildly different and famously opaque. So I thought I would help him out.]
Subject: A brief on healthcare economics. (8 minutes)
o Why healthcare economics are different.
o Why the ACA is failing.
o What would work.
Who I am (credentials): Independent healthcare author and analyst since Jimmy Carter’s administration. Speaker, consu...
Source: The Health Care Blog - March 10, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Healthcare Economics: Why This Stuff Doesn ’ t Actually Work The Way You Think It Does
By JOE FLOWER
This is a letter I sent to Gary Cohn, appointed by President Trump to head the National Economic Council and, among other things, come up with a plan for reforming healthcare. Formerly president of Goldman Sachs, Cohn may be a wizard at finance, but healthcare economics are wildly different and famously opaque. So I thought I would help him out.]
Subject: A brief on healthcare economics. (8 minutes)
o Why healthcare economics are different.
o Why the ACA is failing.
o What would work.
Who I am (credentials): Independent healthcare author and analyst since Jimmy Carter’s administration. Speaker, consu...
Source: The Health Care Blog - March 10, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
Non-Alternative Facts About the Healthcare System
By JOE FLOWER
The economic fundamentals of healthcare in the United States are unique, amazingly complex, multi-layered and opaque. It takes a lot of work and time to understand them, work and time that few of the experts opining about healthcare on television have done. Once you do understand them, it takes serious independence, a big ornery streak, and maybe a bit of a career death wish to speak publicly about how the industry that pays your speaking and consulting fees should, can, and must strive to make half as much money. Well, I turn 67 this year and I’m cranky as hell, so let’s go.
The Wrong Question
We are ba...
Source: The Health Care Blog - February 26, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
