Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Follistatin Gene Therapy Doubles Muscle Mass in Mice
Follistatin is an inhibitor of myostatin. Blocking myostatin activity enhances muscle growth, with accompanying beneficial side-effects such as a loss of excess fat tissue. This is well proven. There are a good number of animal lineages (mice, dogs, cows, and so forth) resulting from natural or engineered myostatin loss of function mutations, and even a few well-muscled human individuals with similar mutations. A number of groups are at various stages in the development of therapies to either upregulate follistatin or inhibit myostatin. The latter is further along in the formal regulatory process: human trials have been co...
Source: Fight Aging! - May 18, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Time Really Can Be Money
By KIM BELLARD If you are not an IKEA fan, or haven’t been spending any time in Dubai, you may have missed the chain’s marketing campaign to help promote its second store in the area.  Titled “Buy With Your Time,” customers got store credits for how long they spent getting to the store.  Gosh, that’s something that should make any self-respecting critic of the U.S. healthcare system perk up.  Count me as intrigued. The campaign involved checking the customer’s Google Maps’ Trip tab to determine how long it took them to get to the store.  IKEA benchmarke...
Source: The Health Care Blog - February 27, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients Buy With Your Time Ikea Kim Bellard Source Type: blogs

Fight Aging! Newsletter, February 24th 2020
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve. A Comparison of Biological Age Measurement Approaches https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/ Researchers here assess the performance of a range of approaches to measuring biological...
Source: Fight Aging! - February 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Request for Startups in the Rejuvenation Biotechnology Space, 2020 Edition
This is the latest in a series of yearly posts in which I suggest areas of development for biotech startups I'd like to see actively developed as a part of the longevity industry in the near future. Today, this year, is a good time to be starting a company focused on the production of a novel therapeutic approach to intervening in the aging process. There is a great deal of funding for seed stage investment, and many compelling projects lacking champions, yet to be carried forward from academia into preclinical development. Numerous scientific and industry crossover conferences are now held every year, at which it is possi...
Source: Fight Aging! - February 17, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging Thymic Involution Contributes to Immunosenescence and Inflammaging The Potential for Exosome Therapies to Treat Sarcopenia Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice The Aging Retina, a Mirror of the Aging Brain Evidence for Loss of Capillary Density to be Important in Heart Disease Aspects of Immune System Aging Proceed More Rapidly in Men Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation Transplantation of Senescent Cells is an ...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Prospects for Telomerase Gene Therapy as a Treatment for Heart Disease
Telomerase gene therapy is considered in some quarters to be a viable treatment for aging. Telomeres are the caps of repeated DNA sequences at the ends of chromosomes. They are an important part of the mechanism limiting the number of times that somatic cells in the body can divide, the Hayflick limit. A little telomere length is lost with each cell division, and short telomeres trigger cellular senescence or programmed cell death, halting replication. Stem cell populations use telomerase to lengthen their telomeres and thus self-renew to provide a continual supply of new somatic daughter cells with long telomeres to repla...
Source: Fight Aging! - February 12, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Bundled Cash Pricing May Provide an Ideal " Transparency " Solution for Many Hospitals
Major changes are now underway in the healthcare industry including the impending CMS price transparency rules that are eliciting marked opposition from various segments of organized medicine (see:Ohio Healthcare Network Serving Amish and Anabaptist Communities Could Provide Blueprint for Hospital Price Transparency). Below is an excerpt from an article on this topic inDark Daily:.... [O]n Jan. 1, 2021, a new Centers for Medicare and Medicaid Services (CMS) final rule (CMS-1717-F2) on price transparency goes into effect. It requires hospitals to publish their standard chargemaster prices, as well as payer-negotiated p...
Source: Lab Soft News - February 11, 2020 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Healthcare Delivery Healthcare Innovations Hospital Executive Management Hospital Financial Medical Consumerism Source Type: blogs

Ethics Dumping and Medical Tourism In A Fertility Study in Mexico
by Craig Klugman, Ph.D. Last week, NPR reported on a new pre-publication article published in the journal Human Reproduction (HR). The study was conducted in Mexico where 81 women received in vivo assisted reproduction (a cycle of ovarian stimulation followed by artificial insemination—introduction of sperm into her body). After several days, researchers used the patented Previvo Genetics1 lavage device to wash the embryos out her uterus. Twenty of these women also underwent a (second) more traditional in vitro fertilization (IVF) cycle and all embryos were tested for “euploidy rates” (having the cor...
Source: blog.bioethics.net - January 24, 2020 Category: Medical Ethics Authors: Craig Klugman Tags: Clinical Trials & Studies Featured Posts Global Ethics Health Disparities Health Regulation & Law Human Subjects Research & IRBs Reproductive Ethics Research Ethics Source Type: blogs

Fight Aging! Newsletter, November 25th 2019
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
Source: Fight Aging! - November 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Libella Gene Therapeutics to Run a Patient Paid Trial of Telomerase Gene Therapy
After Bioviva Science, Libella Gene Therapeutics is the second company to take a run at commercializing telomerase gene therapy treatments for human use. Telomerase is the enzyme responsible for lengthening telomeres, repeated DNA sequences at the ends of chromosomes, though it may have other roles. Telomeres are a part of the mechanism that limits the number of times that a somatic cell can replicate. Telomeres shorten with each cell division, and when too short they trigger programmed cell death or cellular senescence followed by destruction by the immune system. Ordinary somatic cells in humans do not express telomerase...
Source: Fight Aging! - November 22, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

The Opportunity in Disruption, Part 4: Success Strategies for Provider and Payer CFOs
By JOE FLOWER The system is unstable. We are already seeing the precursor waves of massive and multiple disturbances to come. Disruption at key leverage points, new entrants, shifting public awareness and serious political competition cast omens and signs of a highly changed future. So what’s the frequency? What are the smart bets for a strategic chief financial officer at a payer or provider facing such a bumpy ride? They are radically different from today’s dominant consensus strategies. In this five-part series, Joe Flower lays out the argument, the nature of the instability, and the best-bet strategie...
Source: The Health Care Blog - September 30, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Uncategorized Source Type: blogs

New Twist on Medical Tourism; American Surgeon Travels to Cancun Hospital
I have posted a number of blog notes over the years about medical tourism. The options when seeking medical care abroad have taken many twists and turns (see, for example:Medical Tourism Business Model in Thailand Extends to Airport Facilities;A Competitive Threat to U.S. Healthcare in the Cayman Islands?). The latest twist entails having an American orthopedic surgeon travel to a Mexican hospital to perform the operation (see:A Mexican Hospital, an American Surgeon, and a $5,000 Check (Yes, a Check)), Below is an excerpt from an article on this topic:For...[her knee replacement],...[Donna Ferguson] would not only receive ...
Source: Lab Soft News - August 28, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Healthcare Innovations Medical Consumerism Quality of Care Source Type: blogs

The Rebellion of the Buyers
By JOE FLOWER Did you catch that headline a few weeks back? An official of a health system in North Carolina sent an email to the entire board of the North Carolina State Health Plan calling them a bunch of “sorry SOBs” who would “burn in hell” after they “bankrupt every hospital in the state.” Wow. He sounds rather upset. He sounds angry and afraid. He sounds surprised, gobsmacked, face-palming. Bless his heart. I get it, I really do. Well, I get the fear and pain. Here’s what I don’t get: the surprise, the tone of, “This came out of nowhere! Why didn&rsq...
Source: The Health Care Blog - August 15, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Economics Health Policy buyers health economics health reform Joe Flower Payers Source Type: blogs

Reducing Healthcare Costs; Surgery at a Selected Hospital and Pharma Tourism
Individuals and self-insured companies have adopted various strategies to reduce the rising cost of healthcare for themselves and their employees. A recent article discussed howWalmart was flying employees who were candidates for particular surgical procedures to selected, distant hospitals for evaluation (see:Walmart Flies Employees to Top Hospitals for Surgeries in a Bid to Cut Healthcare Costs). Below is an excerpt from it:Walmart ’s answer [to rising healthcare costs] is its six-year-oldCenters of Excellence (COE) program. In partnership with third-party administrator Health Design Plus (HDP), Walmart directly co...
Source: Lab Soft News - July 16, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Healthcare Innovations Healthcare Insurance Medical Consumerism Pharmaceutical Industry Public Health Quality of Care Source Type: blogs

Fight Aging! Newsletter, May 13th 2019
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - May 12, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Rejuvenation Therapies Will Also Have Cycles of Hope and Disillusionment
Every new class of rejuvenation therapy, and there will be many of them in the decades ahead, will follow a cycle consisting of a few years of rapidly growing hype, followed by a sharp crash of disappointment, and then, ultimately, long years of slow and steady success. People attach great hopes to the early stages of every new technology, unrealistic expectations for sweeping, immediate change and benefit. Those expectations are usually possible to realize in the long term, but they can only be met in the later stages of development, perhaps several decades after the advent of the new approach to rejuvenation. Producing a...
Source: Fight Aging! - May 6, 2019 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Coronary Stent Price Control in India: Two Years and Counting
By SOMALARAM VENKATESH MD With a stated intent of bringing social justice and financial relief to hundreds of thousands of patients undergoing coronary angioplasty in the country every year, the Government of India capped the sale price of coronary stents in Feb 2017. Stent prices fell by as much as 80% with this populist move, seen as anti-trade within the industry circles. It is tempting for a practising interventional cardiologist to look at two years of this government control on medical device prices in a market economy. Before price-capping, angioplasty patients were indeed getting a raw deal. There was no uniformity...
Source: The Health Care Blog - March 4, 2019 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Physicians cardiology coronary stent prices India Somalaram Venkatesh Source Type: blogs

Fight Aging! Newsletter, March 4th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - March 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Request for Startups in the Rejuvenation Biotechnology Space, 2019 Edition
I am a little late with the 2019 list of projects in rejuvenation biotechnology that I'd like to see startups tackling sometime soon. In my defense, this year I have a startup of my own to keep up with, and the first part of 2019 was a wall to wall series of conferences alternating between the US and Europe. It continues to be the case that this is a new industry of near endless potential, yet little of that potential is under active development. This is the state of affairs despite the arrival of hundreds of millions of dollars in venture funds managed by the like of Juvenescence, Life Biosciences, and so on. The research...
Source: Fight Aging! - February 25, 2019 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Thoughts on Near Term Rejuvenation Therapies
At this year's RAADfest event, the interviewer noted here was taking an informal survey of optimistic versus pessimistic attitudes towards progress in the decades ahead. Apparently I was on the pessimistic end of the spectrum. Once past the present highly active development of senolytic therapies to remove senescent cells from old tissues, I think it quite plausible that we'll see a gap of a decade before the next class of SENS-like rejuvenation therapy arrives at the point of availability via medical tourism. The likely candidates include clearance of cross-links and restoration of the immune system via thymic regrowth. ...
Source: Fight Aging! - December 14, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Mission-Hostile Hospital Management: Quieter, but Still Pernicious After All These Years
Hospitals exist to take care of sick people, with the goal of making them better.  Hospitals employ and work with health care professionals, again who are sworn to put taking care of patients ahead of all other concerns.However, since we foundedHealth Care Renewal, we have noted striking examples of hospital leaders threatening their hospitals'fundamental mission and/or health care professionals'core values, which we dubbedmission-hostile management.  We also saw mission-hostile management affecting the broader health care industry, particularly pharmaceutical and device companies.  Most recently, the most s...
Source: Health Care Renewal - December 10, 2018 Category: Health Management Tags: hospitals imperial CEO managerialism mission-hostile management perverse incentives Source Type: blogs

Fight Aging! Newsletter, November 5th 2018
In conclusion, weight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss. Support for Oxidized Cholesterol as a Primary Cause of Atherosclerosis https://www.fightaging.org/archives/2018/11/support-for-oxidized-cholesterol-as-a-primary-cause-of-atherosclerosis/ In the paper I'll point out today, the authors provide evidence in support of the concept that it is specifically oxidized cholesterol that is the primary cause of atherosclerosis rather than the condition resulting from too much cholesterol in general. In atheroscl...
Source: Fight Aging! - November 4, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Recent Research into the Interaction of Exercise and Aging
Today's open access papers touch on aspects of the interaction between exercise and the pace of aging. People age at somewhat different rates, and for the vast majority of us lifestyle is a far greater determinant of that rate than our genes. Until such time as the clinical deployment of rejuvenation therapies is well underway, and in regions of the world sufficiently wealthy to have tamed the majority of infectious disease, it remains the case that our choices regarding our health, such as calorie restriction and exercise, are the most reliable means of improving life expectancy. The size of the effect is not enormous in ...
Source: Fight Aging! - November 2, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, August 20th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - August 19, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

JNK as a Target for Enhancement Therapies Promoting Muscle Growth
Myostatin inhibition and upregulation of the myostatin inhibitor follistatin are approaches to spurring increased muscle growth. This class of approach has been shown to work in humans to at least some degree, and there are numerous heavily muscled myostatin loss of function mutants in various animal species, both naturally occurring and created via genetic technologies. SMAD2 is a related regulatory protein, and some efforts to increase muscle growth have targeted it. Further exploration in this same cluster of regulatory proteins leads to JNK, the subject of today's open access paper. This portion of mammalian bio...
Source: Fight Aging! - August 13, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Trade Warriors Exclude a Third of U.S. Exports from “Trade Deficits”
Private services account for 69% of GDP, and 128.2 million jobs in June. In theBureau of Economic Analysis industry accounts,private service industries“consist of utilities; wholesale trade; retail trade; transportation and warehousing; information; finance, insurance, real estate, rental, and leasing; professional and business services; educational services, health care, and social assistance; arts, entertainment, recreational, accommodation, a nd food services; and other services (except public administration).”Goods-producing industries, by contrast, “consist of agriculture, forestry, fishing, and hunt...
Source: Cato-at-liberty - July 9, 2018 Category: American Health Authors: Alan Reynolds Source Type: blogs

Fight Aging! Newsletter, July 9th 2018
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - July 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cardiac Muscle Cell Therapy Improves Function after Heart Attack in Monkeys
Cell therapies are thought to have great promise as a way to help repair damaged tissue that will not normally regenerate to any great degree. When it comes to the heart, and following nearly two decades of stem cell and other therapies tested in trials and via medical tourism, the research community is still in search of a reliable, highly effective methodology. Work in the laboratory continues, and researchers have recently reported improvement in heart function following heart attack in Southern pig-tailed macaques. The approach used here involves generating a sizable cell population of cardiomyocytes, heart musc...
Source: Fight Aging! - July 3, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, June 18th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 17, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Not Everyone Feels the Urgent Need for Therapies to Treat Aging, and this is a Sizable Divide in our Broader Community
One of the many important points made by the advocacy community for rejuvenation research is that participants in the mainstream of medical science and medical regulation are not imbued with a great enough sense of urgency. We are all dying, and yet with each passing year the regulatory process moves ever more slowly, rejects an ever greater number of prospective therapies, becomes ever more expensive. The number of new therapies reaching the clinic falls. Regulators continue to reject the idea that treating aging is an acceptable goal in medicine. We live in an age of revolutionary progress in the capabilities of biotechn...
Source: Fight Aging! - June 16, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

There Are Buoys: The Real Path to Lower cost in the Coming Catastrophic Deformation of Healthcare
By JOE FLOWER There are buoys, far out in the ocean, that bob in the waves and signal, through satellites, when the surf will rise at Mavericks on the California coast, or when the tsunami will hit. Here comes. Healthcare in the U.S. is a hollow economy, inflated, impossible, all over patches and gimcracks and work-arounds puffed up on clouds of hot air generated by sweaty, dedicated crews of policy panjandrums and podium pundits burning forests of acronyms. True, that’s just looking at the bad side. But this bad side goes all the way around. Will it pop? Will it undergo catastrophic exothermal deformation? Is it th...
Source: The Health Care Blog - April 26, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Joe Flower Source Type: blogs

Consider this Speculative Scenario on WMT-HUM
By TORY WOLF WMT is in talks with HUM about a relationship enhancement, possibly an acquisition. The two already know how to work together in alliances (narrow pharmacy network, marketing collaborations, points programs). If a new structure is needed, WMT and HUM must be considering a major expansion of scope or a set of operating models where contributions are difficult to attribute and reward (e.g. joint asset builds). What is on their minds? Beyond any interim incremental moves, what could be the endgame? Catching convergence fever Horizontal combinations among the top five health plans have arguably reached the regulat...
Source: The Health Care Blog - April 24, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Consider this Speculative Scenario on Walmart & Humana
By TORY WOLFF Walmart (WMT) is in talks with Humana (HUM) about a relationship enhancement, possibly an acquisition. The two already know how to work together in alliances (narrow pharmacy network, marketing collaborations, points programs). If a new structure is needed, WMT and HUM must be considering a major expansion of scope or a set of operating models where contributions are difficult to attribute and reward (e.g. joint asset builds). What is on their minds? Beyond any interim incremental moves, what could be the endgame? Catching convergence fever Horizontal combinations among the top five health plans have arguably...
Source: The Health Care Blog - April 24, 2018 Category: Consumer Health News Authors: John Irvine Tags: Aetna-CVS The Business of Health Care Humana Walmart Source Type: blogs

Fight Aging! Newsletter, April 23rd 2018
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - April 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Nuanced Opposition to the FDA and Similar Regulatory Agencies
As regular readers will know, I am no great admirer of medical regulation as it presently exists in the wealthier parts of the world. It is a burdensome system, in which whatever power good intentions have to make the world a better place has long been eroded away by the short-term human incentives present in any large bureaucratic organization. What is left is a system in which it costs multiples of what it should cost to bring medicine into the clinic at an appropriate level of risk, a system that acts primarily to suppress rather than encourage development of new medical technology, and a system that tramples upon the r...
Source: Fight Aging! - April 16, 2018 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs

O ’NA HealthCare: A new healthcare insurance option?
I was recently invited to speak at David Wolfe’s Longevity NOW conference in Anaheim, California, where I gave a talk entitled “Germs, Muscle, and Pac-Man: New Strategies for Turning the Clock Back 10 or 20 Years” detailing some new strategies for maintaining youthfulness and vigor. (It was a longevity conference, after all. I shall be posting a similar talk on our Undoctored Inner Circle website in the next few days.) Of the 40-some vendor booths that were part of the conference, there was one that caught my eye: O’NA HealthCare. They claim to provide coverage for functional medicine care, integrat...
Source: Wheat Belly Blog - April 11, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle health insurance healthcare low-cost Source Type: blogs

The Myth That Refuses to Die: All Health Care is Local
By PAUL KECKLEY In 1980, industry healthcare planners imagined a system where the centerpiece was a hospital in every community and a complement of physicians. Demand forecasting was fairly straightforward: based on the population’s growth and age, the need was 4 beds per thousand and 140 docs per 100,000, give or take a few. In 1996, the Dartmouth Center for the Evaluative Clinical Sciences published the Dartmouth Atlas on Health Care quantifying variability in the intensity of services provided Medicare enrollees in each U.S. zip code. They defined 306 hospital referral regions (HRRs) that remain today as the basis...
Source: The Health Care Blog - March 29, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Paul Keckley Source Type: blogs

What Are the Consequences of Big Tech Entering the Healthcare Market?
For about the past decade, an open question about Big Tech has been their possible entry strategy into healthcare and whether they would be successful. Healthcare constitutes a very large portion of the U.S. economy so it won't be ignored by tech giants such as Apple, Google, Microsoft, and even Facebook. A recent article addressed this specific question (see:How Big Tech Is Going After Your Health Care). It's long so read the whole article if interested. Below is an excerpt from it:Apple, Google, Microsoft and other tech giants have transformed the way billions of us communicate, shop, socialize and work. Now...
Source: Lab Soft News - January 3, 2018 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Electronic Health Record (EHR) Healthcare Business Healthcare Information Technology Lab Information Medical Consumerism Source Type: blogs

Fight Aging! Newsletter, January 1st 2018
Discussion of advocacy for the cause is a usual feature of our community, as we try things and attempt to make progress in persuading the world that rejuvenation research is plausible, practical, and necessary. There are more people engaged in advocacy now than at any time in the past decade, and so discussions of strategy come up often. New ventures kicked off in 2017 include the Geroscience online magazine, and among the existing ventures the LEAF / Lifespan.io volunteers seem to be hitting their stride. The mainstream media continues to be as much a hindrance as a help, and where it is a help you will usually find Aubre...
Source: Fight Aging! - December 31, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

BioViva Illustrates the Tension Between Progress and Regulation
Elizabeth Parrish of BioViva, you might recall, has made every effort to publicize the follistatin and telomerase gene therapy that she underwent. This is a strategy intended to accelerate progress; I suspect she was not the first, and that others were just more circumspect. The technology exists, it is not expensive in the grand scheme of things, and at the very least hundreds of people have the laboratory access and the knowledge to carry out such an operation. BioViva's efforts, and those of other ventures such as the Odin and Ascendance Biomedical illustrate the tension between desire for progress and desire for regula...
Source: Fight Aging! - December 27, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Request for Startups in the Rejuvenation Biotechnology Space, 2018 Edition
A shift in the character of rejuvenation research has taken place over the past couple of years. Greater attention is being given to this work, and the most advanced lines have made - or will soon make - the leap from non-profit laboratory and philanthropic funding to for-profit startup company and venture funding. A growing community of angel investors and a fair few venture funds are now interested in supporting startup companies whose founders implement approaches to rejuvenation that follow the SENS model of repairing fundamental damage. A brief selection includes Kizoo Technology Ventures, Methuselah Fund, the Longevi...
Source: Fight Aging! - December 26, 2017 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Fight Aging! Newsletter, December 11th 2017
In this study, we used the Clinical Practice Research Datalink (CPRD) to estimate clinically measured SBP and DBP trajectories for 20 years prior to death, for individuals dying at 60 years and older. Second, we compared the linear SBP trends for years 10 to 3 years before death in patients who died and age- and sex-matched controls who survived at least 9 years. These approaches aimed to separate age from end-of-life associations, and avoid healthy survivor biases. Twenty years before death, estimated mean SBPs increased with increasing age at death (60-69 years, 139.5 mm Hg; ≥90 years, 150.0 mm Hg). All age-at-...
Source: Fight Aging! - December 10, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Low Cost Biotechnologies can be Inconvenienced but not Halted by Regulators
The coming era of gene therapies will be considerably more distributed and bottom-up than the advent of stem cell therapies. This will be a dynamic industry in which many small groups compete to set up distribution of mail order kits and clinics to provide widespread access to therapies. Regulators will attempt to suppress all of this, and will largely fail, as money talks and many regions will choose to host the businesses that offer gene therapies. This will come to pass because gene therapy technologies are many times cheaper, more easily managed, and capable of centralization and mass production than stem cell technolo...
Source: Fight Aging! - December 4, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A conversation with a Rigvir flack
Over the last two Mondays, I've beenwriting about an unproven cancer therapy that I hadn't really heard much about before. The cancer treatment is called Rigvir; it is manufactured in Latvia and marketed primarily through a Latvian entity called the International Virotherapy Center (IVC). To recap, Rigvir is an unmodified Echovirus, specifically ECHO-7, that, according to the IVC, seeks out cancer cells, replicates in them, and thus lyses the cancer cells (causes their membranes to break, spilling out the cancer cells contents, thus killing the cell), hence the term " oncolytic virus. " Somehow, mysteriously Rigv...
Source: Respectful Insolence - October 9, 2017 Category: Surgery Authors: oracknows Source Type: blogs

Fight Aging! Newsletter, September 4th 2017
In conclusion, KPE delays intrinsic skin aging process by inhibiting cellular senescence and mitochondrial dysfunction. KPE does not only attenuate cellular senescence through inhibition of the p53/p21, p16/pRb, and PI3K/AKT signaling pathways but also improve mitochondrial biogenesis through PGC-1α stimulation. Consequently, KPE prevents wrinkle formation, skin atrophy, and loss of elasticity by increasing collagen and elastic fibers in hairless mice. The Society for the Rescue of our Elders https://www.fightaging.org/archives/2017/08/the-society-for-the-rescue-of-our-elders/ The Society for the...
Source: Fight Aging! - September 3, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Success in Rejuvenation Research to Date is Partial: Many Projects Still Need Our Philanthropic Support to Flourish
The past few years have seen very encouraging progress in rejuvenation research and the commercial development of therapies. Senolytic treatments capable of clearing senescent cells, one of the root causes of aging, are moving towards human trials, with a number of companies hard at work on therapies at various stages of development. The animal data continues to roll in, and continues to look very promising, with senescent cells shown to contribute directly to an increasing number of age-related conditions. In addition the established mainstream efforts to remove age-related protein aggregates such as amyloid-β, tau, ...
Source: Fight Aging! - August 29, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, August 28th 2017
In conclusion, CAVD is highly prevalent. Long understood as a passive process, it is now known to be complex and one which involves pathophysiological mechanisms similar to those of atherosclerosis. Understanding these mechanisms could help to establish new therapeutic targets that might allow us to halt or at least slow down the progression of the disease. Early Steps in the Tissue Engineering of Intervertebral Discs https://www.fightaging.org/archives/2017/08/early-steps-in-the-tissue-engineering-of-intervertebral-discs/ In this paper, researchers report on progress towards the manufacture of interver...
Source: Fight Aging! - August 27, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Clearing Senescent Cells Partially Reverses Osteoporosis in Mice
Senescent cells accumulate in tissues with age, a consequence of the normal operation of cellular biochemistry. While these cells can be beneficial in small numbers and for short period of times, such as while playing a role in wound healing, it is unfortunately the case that - when present in large numbers and lingering for years - the activities of these cells contribute meaningfully to the progression of age-related disease. Their signals and other secreted molecules generate chronic inflammation, corrode tissue structure, and alter the behavior of normal cells for the worse. Senescent cells are one of the causes of a...
Source: Fight Aging! - August 22, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

An Introduction to Mesenchymal Stem Cells in Regenerative Research
This open access paper provides an introduction to the widespread use of mesenchymal stem cells (MSCs) in regenerative medicine and research. This is one of the better documented stem cell populations. The scientific and medical communities have more experience with these cells than is the case for most other stem cell types, the methodologies for use are more established, and as a consequence MSCs have been and continue to be used in many clinical trials, cell therapies available via medical tourism, and lines of ongoing research. That said, these cells are training wheels in a way, one present step on a longer road. The ...
Source: Fight Aging! - July 28, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs