After all the years of medical training, I learned how to treat ugly on my own
We first met about two years ago when she came to see me in my clinic as a new patient. I glanced through her chart and reviewed her scans and pathology reports. She had one of the worst possible kinds of lung cancers, called small cell lung cancer, that had spread to both of her […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 6, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/farhan-s-imran" rel="tag" > Farhan S. Imran, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs
A New Model Suggests a Higher Burden of Death Due to Particulate Air Pollution
This study demonstrates that the fossil fuel component of PM2.5 contributes a large mortality burden. The steeper concentration-response function slope at lower concentrations leads to larger estimates than previously found in Europe and North America, and the slower drop-off in slope at higher concentrations results in larger estimates in Asia. (Source: Fight Aging!)
Source: Fight Aging! - April 5, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 22nd 2021
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal.
Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - March 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting of Telomere Lengthening Processes will be the Basis of the Next Generation of Cancer Therapies
Telomeres are repeated DNA sequences that form the end caps of chromosomes. A little of their length is lost with each cell division, and cells self-destruct or become senescent and cease replication when telomeres become too short. This is a part of the Hayflick limit on cell replication: near all cells in the body can only divide a limited number of times. Stem cells are the first exception, using telomerase to extend telomeres. Cancer cells are the second exception, employing either telomerase or the alternative lengthening of telomeres (ALT) mechanisms that do not operate in normal cells. Telomere lengthening is a univ...
Source: Fight Aging! - March 17, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Listen Better, See Deeper
Combining Medical Attentiveness with Artificial IntelligenceJohn Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Embracing an “ecology of attention” will significantly improve patient care, according to Mark Kissler, MD, at the University of Colorado.1Kissler and his colleagues point out that clinicians spend much of their time multi-tasking and navigating around interruptions. While such juggling acts are often unavailable, it ’s important to occasionally step back and ask: Is this the best use of my tim...
Source: Life as a Healthcare CIO - March 2, 2021 Category: Information Technology Source Type: blogs
Fight Aging! Newsletter, February 15th 2021
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Correlating Cancer Risk with Epigenetic Age
This study assessed cancer risk associations for 3 recently developed methylation-based biomarkers of aging: PhenoAge, GrimAge, and predicted telomere length.
We observed relatively strong associations of age-adjusted PhenoAge with risk of colorectal, kidney, lung, mature B-cell, and urothelial cancers. Similar findings were obtained for age-adjusted GrimAge, but the association with lung cancer risk was much larger, after adjustment for smoking status, pack-years, starting age, time since quitting, and other cancer risk factors. Most associations appeared linear, larger than for the first-generation measures, and w...
Source: Fight Aging! - February 12, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Confronting Stigma From Opioid Use Diorder in Cancer Care
by Fitzgerald Jones, Ho, Sager, Rosielle and MerlinHave you ever been so distressed by a perspective piece that it kept you up at night? The type of rumination that fills you with so much angst that you have no choice but to act. This is exactly how we felt when we read theAAHPM Quarterly Winter 2020 Let ’s Think About It Again.1 (member paywall)The column, which is structured as a sort of written debate in which two authors argue a clinical question, describes a case of a 45-year-old man with severe substance use disorder (SUD) recently diagnosed with extensive-stage small-cell lung cancer. He was offered aggr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 30, 2021 Category: Palliative Care Tags: ftigerald jones ho merlin rosielle sager Source Type: blogs
Confronting Stigma From Opioid Use Disorder in Cancer Care
by Fitzgerald Jones, Ho, Sager, Rosielle and MerlinHave you ever been so distressed by a perspective piece that it kept you up at night? The type of rumination that fills you with so much angst that you have no choice but to act. This is exactly how we felt when we read theAAHPM Quarterly Winter 2020 Let ’s Think About It Again.1 (member paywall)The column, which is structured as a sort of written debate in which two authors argue a clinical question, describes a case of a 45-year-old man with severe substance use disorder (SUD) recently diagnosed with extensive-stage small-cell lung cancer. He was offered aggr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - January 30, 2021 Category: Palliative Care Tags: ftigerald jones ho merlin rosielle sager Source Type: blogs
Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancer Survivors Exhibit Greater Risk of New Cancers and Higher Mortality Due to those Cancers
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - December 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Nutritional lessons from the coronavirus pandemic
You’ve heard the headlines: Upon contracting COVID-19, people with various co-morbidities are at increased risk for becoming critically ill, such as developing acute respiratory distress syndrome necessitating mechanical ventilation. They are several-fold more likely to die of the disease, also.
Among the most common health conditions that put people at high risk for becoming severely ill include:
Obesity
Type 2 diabetes
Hypertension
Coronary disease and heart failure
Cerebrovascular disease
There are other conditions that also confer increased risk such as smoking, lung disease, and lung cancer. But the four condi...
Source: Wheat Belly Blog - December 14, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open coronavirus covid Inflammation insulin pandemic undoctored wheat belly Source Type: blogs
This Lung Cancer Awareness Month is like no other
November is Lung Cancer Awareness Month, a time when many people in my profession shine a spotlight on the dangers of taking lung health for granted. This year, few need the reminder. COVID-19 is deadly, contagious, and upending life as we know it. It is also a lung disease. As a thoracic surgeon, I tell […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 6, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/hoag-memorial-hospital-presbyterian" rel="tag" > Hoag Memorial Hospital Presbyterian < /a > < /span > Tags: Conditions Oncology/Hematology Pulmonology Source Type: blogs
Fatigue and Weakness and a computer interpretation of STEMI
This case was sent by David Carroll, a 2nd year EM resident, and his attending physician Brad Caloia.A 60-something male presented to the ED with weakness and fatigue. He was diagnosed with a viral syndrome anddischarged. He returned later and had a lab and ECG workup. He had no cardiac history. There was no chest pain or shortness of breath.Here is his ECG:The computer interpretation:Rate: 93 | PR 146 | QRSD 112 | QT/QTc(Bazett) 353/439Normal sinus rhythmAnterolateral infarct, acute / ***ACUTE MI*** What do you think?Dr. Carroll astutely realized something was amiss: what is it?There...
Source: Dr. Smith's ECG Blog - October 30, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Lung cancer screening explained by a pulmonologist
Lung cancer screening is a process that is used to detect the presence of lung cancer in otherwise healthy people at high risk for cancer. In 2020, 229,000 people will be diagnosed with lung cancer, and 136,000 people will die from the disease, making it the leading cause of cancer death in the U.S. Data […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 25, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/rizwana-khan" rel="tag" > Rizwana Khan, MD < /a > < /span > Tags: Conditions Oncology/Hematology Source Type: blogs
