Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesThe hypothesis of the proposed intervention is that Granulocyte-macrophage colony-stimulating factor (GM-CSF) has profound effects on antiviral immunity, and can provide the stimulus to restore immune homeostasis in the lung with acute lung injury post COVID-19, and can promote lung repair mechanisms, that lead to a 25% improvement in lung oxygenation parameters. Sargramostim is a man-made form of the naturally-occurring protein GM-CSF.Trial designA phase 4 academic, prospective, 2 arm (1:1 ratio), randomized, open-label, controlled trial.ParticipantsPatients aged 18-80 years admitted to specialized COVID...
Source: Trials - June 4, 2020 Category: Research Source Type: clinical trials
Electronic health record nested pragmatic randomized controlled trial of a reminder system for serum lithium level monitoring in patients with mood disorder: KONOTORI study protocol
DiscussionThe KONOTORI trial uses EHRs to enable the efficient conduct of a pragmatic trial of the reminder system for lithium monitoring. This may contribute to improved quality of care for patients on lithium maintenance therapy.Trial registrationUniversity Hospital Medical Information Network (UMIN) Clinical Trials Registry,UMIN000033633. Registered on 3 July 2018. (Source: Trials)
Source: Trials - December 10, 2019 Category: Research Source Type: clinical trials
Umbilical Cord Blood Cell Transplant Into Injured Spinal Cord With Lithium Carbonate or Placebo Followed by Locomotor Training
Condition: Spinal Cord Injuries Interventions: Biological: Umbilical Cord Blood Mononuclear Cell; Drug: Lithium Carbonate; Other: Placebo; Other: Locomotor Training Sponsors: StemCyte, Inc.; Amarex Clinical Research Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 7, 2019 Category: Research Source Type: clinical trials
