Pelizaeus Merzbacher Disease: DAMS Unplugged
Here is brief teaching video about rare leukodystrophy,  Pelizaeus Merzbacher DiseaseFamous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - September 23, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Fight Aging! Newsletter, December 24th 2018
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors. PRRX1 as a Possible Point of Control for Remyelination https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/ Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operati...
Source: Fight Aging! - December 23, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

PRRX1 as a Possible Point of Control for Remyelination
Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operation of the nervous system, and as a consequence demyelinating conditions such as multiple sclerosis are unpleasant and fatal. Loss of myelin isn't just restricted to named conditions, however: some degree of degradation occurs over the course of aging, and is thought to contribute to the progression of cognitive decline. Thus therapies that can boost myelin maintenance may be of greater interest than it might at first appear. Myelin is mai...
Source: Fight Aging! - December 20, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A case of Alexander disease
Alexander disease is a progressive and often fatal leukodystrophy wherein innumerableRosenthal fibers form. Caused by mutation in the gene encoding GFAP, Alexander disease can be inherited in an autosomal dominant manner, but typically arisesde novo.CerebrumCerebrumCerebellum (Source: neuropathology blog)
Source: neuropathology blog - August 23, 2018 Category: Radiology Tags: neurodegen dz (other) Source Type: blogs

Funtabulously Frivolous Friday Five 217
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blogJust when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 217: children who changed medicine. Question 1In 1796, What did James Phipps (1788-1853) participate in that significantly changed the course of modern medicine?+ Reveal the Funtabulous Answerexpand(document.getElementById('ddet87874616'));expand(document.getElementBy...
Source: Life in the Fast Lane - December 8, 2017 Category: Emergency Medicine Authors: Mark Corden Tags: Frivolous Friday Five Christmas disease cow pox Doogie Howser Edward Jenner Haemophilia B IVF James Phipps Lorenzo's oil. Lorenzo Odone Louise Joy Brown small pox stephen christmas test tube baby Source Type: blogs

Neuropathology Maintenance of Certification Topics
For those taking the maintenance of certification (MOC) examination at some point in the next few years, the American Board of Pathology (ABP) has published topics that may be covered in the examination. The examination consists of 150 multiple-choice questions, 50 of which are required to be in the a category designated " general neuropathology I " . The remaining 100 questions can be from various categories which the examinee chooses (general neuropathology II, degenerative I& II, developmental/pediatric/congenital I& II, neoplastic I& II, and neuromuscular I& II). The ABP provides an MOC examination...
Source: neuropathology blog - November 2, 2016 Category: Radiology Tags: MOC Source Type: blogs

Leukodystrophy Teaching Points-MRI
One year  male child born in caesaerian delivery to non-consanguinous parents,  presents with abnormal movements and delayed milestones with no fever are trauma. The MR imaging shows extensive centrifugal pattern of restricted diffusion of myelin edema in supratentorial (posterior to the anterior gradient) &  infratentorial locations with apparent “Tigroid” appearance with T2 shine through in nature with no significant reduction in ADC with no mass effect or  bleed or volume loss or circle of Willis flow voids abnormality. Though the features are not specific, could suggest leukodystrophies or m...
Source: Sumer's Radiology Site - September 24, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs