Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial)
AbstractObjectivesTo assess the efficacy of several repurposed drugs to prevent hospitalisation or death in patients aged 65 or more with recent symptomatic SARS-CoV-2 infection (COVID-19) and no criteria for hospitalisation.Trial designPhase III, multi-arm (5) and multi-stage (MAMS), randomized, open-label controlled superiority trial.Participants will be randomly allocated 1:1:1:1:1 to the following strategies:Arm 1: Control armArms 2 to 5: Experimental treatment armsPlanned interim analyses will be conducted at regular intervals. Their results will be reviewed by an Independent Data and Safety Monitoring Board. Experime...
Source: Trials - October 13, 2020 Category: Research Source Type: clinical trials
Treatment Efficacy of Low FODMAP Versus Low Lactose Diet in IBS Patients
Condition: IBS - Irritable Bowel Syndrome Interventions: Other: Low Lactose Diet; Other: Low FODMAP Diet Sponsor: Cantonal Hospital of St. Gallen Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 10, 2020 Category: Research Source Type: clinical trials
Does Daily Supplementation of Lactobacillus Acidophilus MPH734, for One Week, Affect Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo
Condition: Lactose Intolerance Interventions: Dietary Supplement: Lactobacillus acidophilus MPH734; Dietary Supplement: Placebo Sponsors: Lemuel W. Taylor IV; Manzo Pharmaceuticals Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 28, 2020 Category: Research Source Type: clinical trials
