Drug Shortages and Rapid Price Escalation: The Latest on the Crisis
The American health system is now into the seventh year of an unprecedented and unplanned shortage of emergency medications. The causes of the shortage continue to be debated, but the root cause is the American manufacturers of intravenous medications, and disputes between those manufacturers and the Federal agencies that oversee drug supply and manufacturing practices (FDA and DEA), over safe manufacturing and quality processes.
The Crisis
There are now life-threatening problems with medication supplies for EMS providers across all classes of emergency medicines. As of June 26, 2017, there are 69 preparations of 28 emerge...
Source: JEMS: Journal of Emergency Medical Services News - July 6, 2017 Category: Emergency Medicine Authors: James J. Augustine, MD, FACEP Tags: News Operations Source Type: news
Drug Shortages and Rapid Price Escalation: The Latest on the Crisis
The American health system is now into the seventh year of an unprecedented and unplanned shortage of emergency medications. The causes of the shortage continue to be debated, but the root cause is the American manufacturers of intravenous medications, and disputes between those manufacturers and the Federal agencies that oversee drug supply and manufacturing practices (FDA and DEA), over safe manufacturing and quality processes.
The Crisis
There are now life-threatening problems with medication supplies for EMS providers across all classes of emergency medicines. As of June 26, 2017, there are 69 preparations of 28 emerge...
Source: JEMS Operations - July 6, 2017 Category: Emergency Medicine Authors: James J. Augustine, MD, FACEP Tags: News Operations Source Type: news
Labetalol Hydrochloride Injection (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 18, 2017 Category: Drugs & Pharmacology Source Type: news
labetalol, Normodyne, Trandate
Title: labetalol, Normodyne, TrandateCategory: MedicationsCreated: 1/16/2000 12:00:00 AMLast Editorial Review: 5/10/2017 12:00:00 AM (Source: MedicineNet High Blood Pressure General)
Source: MedicineNet High Blood Pressure General - May 10, 2017 Category: Cardiology Source Type: news
Labetalol Hydrochloride Injection (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 27, 2017 Category: Drugs & Pharmacology Source Type: news
Labetalol in acute cocaine toxicity: is it safe?
3 out of 5 stars
Acute Toxicity from Topical Cocaine for Epistaxis: Treatment with Labetalol. Richards JR et al. J Emerg Med 2017 Mar;52:311-313.
Abstract
There has long been a debate among toxicologists — still unresolved — as to whether it is safe to use a beta-blocker to treat cocaine-related hypertension and tachycardia. The (theoretical) concern is that since cocaine is both an α- and a β-agonist, blocking the β-receptors could lead to unopposed α stimulation with increased severe hypertension.
Some authors contend that in this setting, labetalol would be safe since it blocks both α and β receptors. Oth...
Source: The Poison Review - March 1, 2017 Category: Toxicology Authors: Leon Gussow Tags: Medical beta blocker cocaine epistaxis labetalol safety toxicity Source Type: news
Labetalol Hydrochloride Injection (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 1, 2017 Category: Drugs & Pharmacology Source Type: news
Trandate (Labetalol) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - January 18, 2017 Category: Drugs & Pharmacology Source Type: news
Excellent review of lipid rescue therapy
3.5 out of 5 stars
Intravenous Lipid Emulsion in the Emergency Department: A Systematic Review of Recent Literature. Cao D et al. J Emerg Med 2014 Dec 19 [Epub ahead of print]
Abstract
This excellent comprehensive review of lipid rescue therapy (LRT) is vitiated only by the unavoidable fact that available clinical evidence is so inconclusive. As the authors point out, published literature consists mostly of case reports and small case series. The vast majority of these reported cases have good outcomes and reflect positive effects from ILE, but the evidence is marred by multiple confounding variables (such as concurren...
Source: The Poison Review - February 25, 2015 Category: Toxicology Authors: Leon Tags: Medical intralipid lipid emulsion lipid rescue therapy lipid sink Review Source Type: news
FDA Announces Recall of Labetalol Hydrochloride Injection: AttorneyOne...
On May 16, the FDA announced that one lot of Labetalol Hydrochloride Injection 100Mg/20 ML (5MG/ML), 20 ML, Multidose Vial by Hospira is recalled due to visible particulates. In light of this news,...(PRWeb May 26, 2014)Read the full story at http://www.prweb.com/releases/2014/05/prweb11883881.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 26, 2014 Category: Pharmaceuticals Source Type: news
Labetalol Hydrochloride Injection 100 MG/20 ML (5MG/ML), 20 ML, Multidose Vial by Hospira: Recall - Visible Particulates
Risk of injection site reactions and local irritation in the blood vessels, tissues and organs or delay in therapy. (Source: FDA MedWatch)
Source: FDA MedWatch - May 16, 2014 Category: American Health Source Type: news
CLUE to emergency antihypertensive approach for end-organ damage
Patients admitted to the emergency department with hypertension and suspected end-organ damage reach target systolic blood pressure faster with a nicardipine infusion than a labetalol bolus, research suggests. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - April 3, 2013 Category: Cardiology Source Type: news
Review: Postpartum management of hypertension
Source: BMJ
Area: News
The British Medical Journal has featured a review on the postpartum management of hypertension. The most common cause of postpartum hypertension is gestational hypertension or pre-eclampsia that persists after delivery.
In terms of medical management, the review states that suggested first line antihypertensive drugs that are safe in breastfeeding mothers include labetalol, nifedipine, and enalapril. (Source: NeLM - Cardiovascular Medicine)
Source: NeLM - Cardiovascular Medicine - February 26, 2013 Category: Cardiology Source Type: news
