Review: Postpartum management of hypertension

Source: BMJ Area: News The British Medical Journal has featured a review on the postpartum management of hypertension. The most common cause of postpartum hypertension is gestational hypertension or pre-eclampsia that persists after delivery.   In terms of medical management, the review states that suggested first line antihypertensive drugs that are safe in breastfeeding mothers include labetalol, nifedipine, and enalapril.
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news

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Authors: Li M, Qian L, Yu J, Zou Y Abstract Objectives: The protective effects of interleukin(IL)-35 against injury to human umbilical vein endothelial cells (HUVECs) induced by the serum of pre-eclampsia patients were analyzed.Methods: This cross-sectional study included 24 patients with pre-eclampsia (PE) and 24 normotensive pregnant women.Results: Compared to normotensive pregnant women, patients with pre-eclampsia had lower IL-35 levels (P
Source: Hypertension in Pregnancy - Category: OBGYN Tags: Hypertens Pregnancy Source Type: research
ConclusionThis study showed a high rate of adverse obstetrical complications without significant impact on live birth rates. Pregnancy did not appear to influence TAK disease activity.Key Points•We observed a high rate of adverse obstetrical complications in women with Takayasu arteritis; however, the rate of live births was high.Pregnancy did not appear to influence TA disease activity.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractPurpose of ReviewTo provide insight on the imbalance of angiogenic and lymphangiogenic factors in pre-eclampsia, as well as highlight polymorphism in genes related to angiogenesis and lymphangiogenesis.Recent FindingsThe pregnancy-specific disorder pre-eclampsia is diagnosed by the presence of hypertension with/without proteinuria, after 20  weeks of gestation. The pathogenesis of pre-eclampsia remains ambiguous, but research over the years has identified an imbalance in maternal and foetal factors. Familial predisposition and gene variation are also linked to pre-eclampsia development. The sFlt-1/PIGF ratio h...
Source: Current Hypertension Reports - Category: Primary Care Source Type: research
Publication date: April 2020Source: Pregnancy Hypertension, Volume 20Author(s): Natasha de Alwis, Sally Beard, Yeukai T. Mangwiro, Natalie K. Binder, Tu'uhevaha J. Kaitu'u-Lino, Fiona C. Brownfoot, Stephen Tong, Natalie J. Hannan
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Abstract OBJECTIVES: We assessed the incidence, risk factors and adverse birth outcomes associated with elevated liver enzymes and low platelets (HELLP) syndrome. DESIGN: A retrospective population-based cohort study. SETTING: Canada (excluding Quebec), 2012/13-2015/16. POPULATION: Mothers with a singleton hospital live birth or stillbirth at ≥24 weeks gestation (N=1,078,323). METHODS: HELLP syndrome was identified using ICD-10-CA diagnostic code from delivery hospitalization data. We used logistic regression to identify independent risk factors for HELLP syndrome by obtaining adjusted ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
Horm Metab Res DOI: 10.1055/a-1120-8647Primary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA. Any functional role of AT1R-Abs in either of the two main subtypes of PA (aldosterone-producing adenoma or bilateral adrenal hyperplasia) requires clarification. In this review, we discuss the studies performed to date on AT1R-Abs in PA. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Review Source Type: research
Publication date: Available online 10 March 2020Source: Pregnancy HypertensionAuthor(s): Merantha Moodley, Jagidesa Moodley, Thajasvarie Naicker
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
CONCLUSIONS: ApoB cannot be used as a marker for identifying the risk of excessive GWG or adverse pregnancy outcomes early in pregnancy. However, it may be involved in the pathophysiology of adverse pregnancy outcomes in high-risk patients. PMID: 32162284 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Geburtshilfe und Neonatologie - Category: Perinatology & Neonatology Authors: Tags: Z Geburtshilfe Neonatol Source Type: research
We report two cases of adolescent PHPT presenting with generalized tonic-clonic seizures and altered sensorium. On evaluation, both had hypertension, severe hypercalcemia (serum calcium 14.1 mg/dl and 14.5 mg/dl, respectively) and elevated parathyroid hormone levels. Magnetic resonance imaging revealed T2/FLAIR hyperintensities located predominantly in the parieto-occipital regions, suggestive of PRES. Localization and excision of parathyroid adenoma led to restoration of normocalcemia. Neurological symptoms and MRI changes improved subsequently. Extensive literature search revealed only four cases of PHPT-associated PRES;...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Conclusion This study found that weekly laboratory testing may have minimal clinical utility in the outpatient management protocol in monitoring patients with mild gestational hypertension or preeclampsia. Delivery was guided by other clinical factors. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: American Journal of Perinatology Reports - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
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