Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations
Xenobiotica. 2024 Mar 22:1-22. doi: 10.1080/00498254.2024.2333009. Online ahead of print.ABSTRACTCefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t) and maximum plasma concentration (Cmax) increas...
Source: Xenobiotica - March 22, 2024 Category: Research Authors: Tahir Saleem Ammara Zamir Muhammad Fawad Rasool None Imran Imran Hamid Saeed Faleh Alqahtani Source Type: research
Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations
Xenobiotica. 2024 Mar 22:1-22. doi: 10.1080/00498254.2024.2333009. Online ahead of print.ABSTRACTCefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t) and maximum plasma concentration (Cmax) increas...
Source: Xenobiotica - March 22, 2024 Category: Research Authors: Tahir Saleem Ammara Zamir Muhammad Fawad Rasool None Imran Imran Hamid Saeed Faleh Alqahtani Source Type: research
Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations
Xenobiotica. 2024 Mar 22:1-22. doi: 10.1080/00498254.2024.2333009. Online ahead of print.ABSTRACTCefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t) and maximum plasma concentration (Cmax) increas...
Source: Xenobiotica - March 22, 2024 Category: Research Authors: Tahir Saleem Ammara Zamir Muhammad Fawad Rasool None Imran Imran Hamid Saeed Faleh Alqahtani Source Type: research
Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations
Xenobiotica. 2024 Mar 22:1-22. doi: 10.1080/00498254.2024.2333009. Online ahead of print.ABSTRACTCefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t) and maximum plasma concentration (Cmax) increas...
Source: Xenobiotica - March 22, 2024 Category: Research Authors: Tahir Saleem Ammara Zamir Muhammad Fawad Rasool None Imran Imran Hamid Saeed Faleh Alqahtani Source Type: research
Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations
Xenobiotica. 2024 Mar 22:1-22. doi: 10.1080/00498254.2024.2333009. Online ahead of print.ABSTRACTCefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t) and maximum plasma concentration (Cmax) increas...
Source: Xenobiotica - March 22, 2024 Category: Research Authors: Tahir Saleem Ammara Zamir Muhammad Fawad Rasool None Imran Imran Hamid Saeed Faleh Alqahtani Source Type: research
Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations
Xenobiotica. 2024 Mar 22:1-22. doi: 10.1080/00498254.2024.2333009. Online ahead of print.ABSTRACTCefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t) and maximum plasma concentration (Cmax) increas...
Source: Xenobiotica - March 22, 2024 Category: Research Authors: Tahir Saleem Ammara Zamir Muhammad Fawad Rasool None Imran Imran Hamid Saeed Faleh Alqahtani Source Type: research
Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations
Xenobiotica. 2024 Mar 22:1-22. doi: 10.1080/00498254.2024.2333009. Online ahead of print.ABSTRACTCefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t) and maximum plasma concentration (Cmax) increas...
Source: Xenobiotica - March 22, 2024 Category: Research Authors: Tahir Saleem Ammara Zamir Muhammad Fawad Rasool None Imran Imran Hamid Saeed Faleh Alqahtani Source Type: research
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 Ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method
Xenobiotica. 2024 Mar 19:1-18. doi: 10.1080/00498254.2024.2333007. Online ahead of print.ABSTRACT1. HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in transforming it into major metabolite ZZ-24. An efficient UPLC-MS/MS method was established to detect HY-072808 and ZZ-24 in plasma and skin tissues of minipigs.2. One-step protein precipitation was performed with acetonitrile. Subsequently, elution was served with a methanol and water gradient containing 0.1% formic acid for 3.5 min. The plasma and skin tissue concentrations of ...
Source: Xenobiotica - March 19, 2024 Category: Research Authors: Li Shao Jiajia Mo Qinlong Xu Guangwei He Chunyu Xing Zhaoxing Chu Source Type: research
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 Ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method
Xenobiotica. 2024 Mar 19:1-18. doi: 10.1080/00498254.2024.2333007. Online ahead of print.ABSTRACT1. HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in transforming it into major metabolite ZZ-24. An efficient UPLC-MS/MS method was established to detect HY-072808 and ZZ-24 in plasma and skin tissues of minipigs.2. One-step protein precipitation was performed with acetonitrile. Subsequently, elution was served with a methanol and water gradient containing 0.1% formic acid for 3.5 min. The plasma and skin tissue concentrations of ...
Source: Xenobiotica - March 19, 2024 Category: Research Authors: Li Shao Jiajia Mo Qinlong Xu Guangwei He Chunyu Xing Zhaoxing Chu Source Type: research
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 Ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method
Xenobiotica. 2024 Mar 19:1-18. doi: 10.1080/00498254.2024.2333007. Online ahead of print.ABSTRACT1. HY-072808 is a novel phosphodiesterase 4 inhibitor clinically used for topical atopic dermatitis treatment. Cytochrome P450 enzymes are involved in transforming it into major metabolite ZZ-24. An efficient UPLC-MS/MS method was established to detect HY-072808 and ZZ-24 in plasma and skin tissues of minipigs.2. One-step protein precipitation was performed with acetonitrile. Subsequently, elution was served with a methanol and water gradient containing 0.1% formic acid for 3.5 min. The plasma and skin tissue concentrations of ...
Source: Xenobiotica - March 19, 2024 Category: Research Authors: Li Shao Jiajia Mo Qinlong Xu Guangwei He Chunyu Xing Zhaoxing Chu Source Type: research
Effects of Pharmacogenetics on Pharmacokinetics and Toxicity of Doxorubicin in Egyptian Breast Cancer Patients
This study investigates the impact of single nucleotide polymorphisms in genes (SLC22A16 and CBR1) involved in the pharmacokinetics and toxicity of doxorubicin (DOX) in Egyptian female patients with breast cancer.2. Patients administered DOX (60 mg/m2) for 4 cycles every 3 weeks. The peak DOX plasma concentration was measured using a validated chromatographic method. The genotyping for the selected SNPs, SLC22A16 T > C (rs714368) and CBR1 C > T (rs20572), was performed by RT-PCR. Patients were monitored for hematological and cardiac toxicities.3. The variant carriers of CBR1 C > T (rs20572) exhibited significantly...
Source: Xenobiotica - March 16, 2024 Category: Research Authors: N F Ebaid K S Abdelkawy M A Shehata H F Salem G Magdy R R S Hussein F Elbarbry Source Type: research
Effects of Pharmacogenetics on Pharmacokinetics and Toxicity of Doxorubicin in Egyptian Breast Cancer Patients
This study investigates the impact of single nucleotide polymorphisms in genes (SLC22A16 and CBR1) involved in the pharmacokinetics and toxicity of doxorubicin (DOX) in Egyptian female patients with breast cancer.2. Patients administered DOX (60 mg/m2) for 4 cycles every 3 weeks. The peak DOX plasma concentration was measured using a validated chromatographic method. The genotyping for the selected SNPs, SLC22A16 T > C (rs714368) and CBR1 C > T (rs20572), was performed by RT-PCR. Patients were monitored for hematological and cardiac toxicities.3. The variant carriers of CBR1 C > T (rs20572) exhibited significantly...
Source: Xenobiotica - March 16, 2024 Category: Research Authors: N F Ebaid K S Abdelkawy M A Shehata H F Salem G Magdy R R S Hussein F Elbarbry Source Type: research
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics
This study investigated whether Safflower Yellow for injection (SYI) would affect the anticoagulation of warfarin in rats.Wistar male rats were divided into six groups randomly and administered with SYI (9 mg/kg, intraperitoneal injection) in single-dose and steady-dose warfarin (0.2 mg/kg, oral gavage), respectively. The pharmacodynamic parameters of PT and APTT were measured by a coagulation analyser. R/S-warfarin concentration was measured by UHPLC-MS/MS, and pharmacokinetic parameters calculated using DAS 2.0 software.The single-dose study demonstrated that SYI, alone or co-administered with warfarin, could significant...
Source: Xenobiotica - March 6, 2024 Category: Research Authors: Yan Liu Jiahui Sun Chunjuan Yang Mengnan Qin Shiwei Xu Yue Zhao Gaofeng Liu Source Type: research
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics
This study investigated whether Safflower Yellow for injection (SYI) would affect the anticoagulation of warfarin in rats.Wistar male rats were divided into six groups randomly and administered with SYI (9 mg/kg, intraperitoneal injection) in single-dose and steady-dose warfarin (0.2 mg/kg, oral gavage), respectively. The pharmacodynamic parameters of PT and APTT were measured by a coagulation analyser. R/S-warfarin concentration was measured by UHPLC-MS/MS, and pharmacokinetic parameters calculated using DAS 2.0 software.The single-dose study demonstrated that SYI, alone or co-administered with warfarin, could significant...
Source: Xenobiotica - March 6, 2024 Category: Research Authors: Yan Liu Jiahui Sun Chunjuan Yang Mengnan Qin Shiwei Xu Yue Zhao Gaofeng Liu Source Type: research
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics
This study investigated whether Safflower Yellow for injection (SYI) would affect the anticoagulation of warfarin in rats.Wistar male rats were divided into six groups randomly and administered with SYI (9 mg/kg, intraperitoneal injection) in single-dose and steady-dose warfarin (0.2 mg/kg, oral gavage), respectively. The pharmacodynamic parameters of PT and APTT were measured by a coagulation analyser. R/S-warfarin concentration was measured by UHPLC-MS/MS, and pharmacokinetic parameters calculated using DAS 2.0 software.The single-dose study demonstrated that SYI, alone or co-administered with warfarin, could significant...
Source: Xenobiotica - March 6, 2024 Category: Research Authors: Yan Liu Jiahui Sun Chunjuan Yang Mengnan Qin Shiwei Xu Yue Zhao Gaofeng Liu Source Type: research
