Absorption, Distribution, Metabolism and Excretion of < sup > 14 < /sup > C-Vatiquinone in Rats, Dogs and Human Subjects
Xenobiotica. 2023 Aug 8:1-19. doi: 10.1080/00498254.2023.2245459. Online ahead of print.ABSTRACTVatiquinone is a potent inhibitor of 15-lipoxygenase and is in clinical development for the treatment of mitochondrial diseases and other disorders characterized by high levels of oxidative stress and dysregulation of energy metabolism.In rats, 14C-vatiquinone-derived radioactivity was quickly and widely distributed throughout the body and cleared from most tissues by 24 h post-dose following a single oral dose of 14C-vatiquinone.Following oral administration, 94% of dose was recovered within 7 days in rats, approximately 61% of...
Source: Xenobiotica - August 8, 2023 Category: Research Authors: Jiyuan Ma Lucy Lee Bert Yao Peter Giannousis Martin Thoolen Qing Ye Lee Golden Matthew Klein Ronald Kong Source Type: research
Absorption, Distribution, Metabolism and Excretion of < sup > 14 < /sup > C-Vatiquinone in Rats, Dogs and Human Subjects
Xenobiotica. 2023 Aug 8:1-19. doi: 10.1080/00498254.2023.2245459. Online ahead of print.ABSTRACTVatiquinone is a potent inhibitor of 15-lipoxygenase and is in clinical development for the treatment of mitochondrial diseases and other disorders characterized by high levels of oxidative stress and dysregulation of energy metabolism.In rats, 14C-vatiquinone-derived radioactivity was quickly and widely distributed throughout the body and cleared from most tissues by 24 h post-dose following a single oral dose of 14C-vatiquinone.Following oral administration, 94% of dose was recovered within 7 days in rats, approximately 61% of...
Source: Xenobiotica - August 8, 2023 Category: Research Authors: Jiyuan Ma Lucy Lee Bert Yao Peter Giannousis Martin Thoolen Qing Ye Lee Golden Matthew Klein Ronald Kong Source Type: research
Absorption, Distribution, Metabolism and Excretion of < sup > 14 < /sup > C-Vatiquinone in Rats, Dogs and Human Subjects
Xenobiotica. 2023 Aug 8:1-19. doi: 10.1080/00498254.2023.2245459. Online ahead of print.ABSTRACTVatiquinone is a potent inhibitor of 15-lipoxygenase and is in clinical development for the treatment of mitochondrial diseases and other disorders characterized by high levels of oxidative stress and dysregulation of energy metabolism.In rats, 14C-vatiquinone-derived radioactivity was quickly and widely distributed throughout the body and cleared from most tissues by 24 h post-dose following a single oral dose of 14C-vatiquinone.Following oral administration, 94% of dose was recovered within 7 days in rats, approximately 61% of...
Source: Xenobiotica - August 8, 2023 Category: Research Authors: Jiyuan Ma Lucy Lee Bert Yao Peter Giannousis Martin Thoolen Qing Ye Lee Golden Matthew Klein Ronald Kong Source Type: research
Absorption, Distribution, Metabolism and Excretion of < sup > 14 < /sup > C-Vatiquinone in Rats, Dogs and Human Subjects
Xenobiotica. 2023 Aug 8:1-19. doi: 10.1080/00498254.2023.2245459. Online ahead of print.ABSTRACTVatiquinone is a potent inhibitor of 15-lipoxygenase and is in clinical development for the treatment of mitochondrial diseases and other disorders characterized by high levels of oxidative stress and dysregulation of energy metabolism.In rats, 14C-vatiquinone-derived radioactivity was quickly and widely distributed throughout the body and cleared from most tissues by 24 h post-dose following a single oral dose of 14C-vatiquinone.Following oral administration, 94% of dose was recovered within 7 days in rats, approximately 61% of...
Source: Xenobiotica - August 8, 2023 Category: Research Authors: Jiyuan Ma Lucy Lee Bert Yao Peter Giannousis Martin Thoolen Qing Ye Lee Golden Matthew Klein Ronald Kong Source Type: research
Absorption, Distribution, Metabolism and Excretion of < sup > 14 < /sup > C-Vatiquinone in Rats, Dogs and Human Subjects
Xenobiotica. 2023 Aug 8:1-19. doi: 10.1080/00498254.2023.2245459. Online ahead of print.ABSTRACTVatiquinone is a potent inhibitor of 15-lipoxygenase and is in clinical development for the treatment of mitochondrial diseases and other disorders characterized by high levels of oxidative stress and dysregulation of energy metabolism.In rats, 14C-vatiquinone-derived radioactivity was quickly and widely distributed throughout the body and cleared from most tissues by 24 h post-dose following a single oral dose of 14C-vatiquinone.Following oral administration, 94% of dose was recovered within 7 days in rats, approximately 61% of...
Source: Xenobiotica - August 8, 2023 Category: Research Authors: Jiyuan Ma Lucy Lee Bert Yao Peter Giannousis Martin Thoolen Qing Ye Lee Golden Matthew Klein Ronald Kong Source Type: research
Absorption, Distribution, Metabolism and Excretion of < sup > 14 < /sup > C-Vatiquinone in Rats, Dogs and Human Subjects
Xenobiotica. 2023 Aug 8:1-19. doi: 10.1080/00498254.2023.2245459. Online ahead of print.ABSTRACTVatiquinone is a potent inhibitor of 15-lipoxygenase and is in clinical development for the treatment of mitochondrial diseases and other disorders characterized by high levels of oxidative stress and dysregulation of energy metabolism.In rats, 14C-vatiquinone-derived radioactivity was quickly and widely distributed throughout the body and cleared from most tissues by 24 h post-dose following a single oral dose of 14C-vatiquinone.Following oral administration, 94% of dose was recovered within 7 days in rats, approximately 61% of...
Source: Xenobiotica - August 8, 2023 Category: Research Authors: Jiyuan Ma Lucy Lee Bert Yao Peter Giannousis Martin Thoolen Qing Ye Lee Golden Matthew Klein Ronald Kong Source Type: research
Absorption, Distribution, Metabolism and Excretion of < sup > 14 < /sup > C-Vatiquinone in Rats, Dogs and Human Subjects
Xenobiotica. 2023 Aug 8:1-19. doi: 10.1080/00498254.2023.2245459. Online ahead of print.ABSTRACTVatiquinone is a potent inhibitor of 15-lipoxygenase and is in clinical development for the treatment of mitochondrial diseases and other disorders characterized by high levels of oxidative stress and dysregulation of energy metabolism.In rats, 14C-vatiquinone-derived radioactivity was quickly and widely distributed throughout the body and cleared from most tissues by 24 h post-dose following a single oral dose of 14C-vatiquinone.Following oral administration, 94% of dose was recovered within 7 days in rats, approximately 61% of...
Source: Xenobiotica - August 8, 2023 Category: Research Authors: Jiyuan Ma Lucy Lee Bert Yao Peter Giannousis Martin Thoolen Qing Ye Lee Golden Matthew Klein Ronald Kong Source Type: research
< em > In Silico < /em > ADME/Tox Comes of Age: Twenty Years Later
Xenobiotica. 2023 Aug 4:1-11. doi: 10.1080/00498254.2023.2245049. Online ahead of print.ABSTRACTIn the early 2000s pharmaceutical drug discovery was beginning to use computational approaches for absorption, distribution, metabolism, excretion and toxicity (ADME/Tox, also known as ADMET) prediction. This emphasis on prediction was an effort to reduce the risk of later stage failures from ADME/Tox.Much has been written in the intervening twenty plus years and significant expenditure has occurred in companies developing these in silico capabilities which can be gleaned from publications. It is therefore an appropriate time to...
Source: Xenobiotica - August 4, 2023 Category: Research Authors: Sean Ekins Thomas R Lane Fabio Urbina Ana C Puhl Source Type: research
< em > In Silico < /em > ADME/Tox Comes of Age: Twenty Years Later
Xenobiotica. 2023 Aug 4:1-11. doi: 10.1080/00498254.2023.2245049. Online ahead of print.ABSTRACTIn the early 2000s pharmaceutical drug discovery was beginning to use computational approaches for absorption, distribution, metabolism, excretion and toxicity (ADME/Tox, also known as ADMET) prediction. This emphasis on prediction was an effort to reduce the risk of later stage failures from ADME/Tox.Much has been written in the intervening twenty plus years and significant expenditure has occurred in companies developing these in silico capabilities which can be gleaned from publications. It is therefore an appropriate time to...
Source: Xenobiotica - August 4, 2023 Category: Research Authors: Sean Ekins Thomas R Lane Fabio Urbina Ana C Puhl Source Type: research
< em > In Silico < /em > ADME/Tox Comes of Age: Twenty Years Later
Xenobiotica. 2023 Aug 4:1-11. doi: 10.1080/00498254.2023.2245049. Online ahead of print.ABSTRACTIn the early 2000s pharmaceutical drug discovery was beginning to use computational approaches for absorption, distribution, metabolism, excretion and toxicity (ADME/Tox, also known as ADMET) prediction. This emphasis on prediction was an effort to reduce the risk of later stage failures from ADME/Tox.Much has been written in the intervening twenty plus years and significant expenditure has occurred in companies developing these in silico capabilities which can be gleaned from publications. It is therefore an appropriate time to...
Source: Xenobiotica - August 4, 2023 Category: Research Authors: Sean Ekins Thomas R Lane Fabio Urbina Ana C Puhl Source Type: research
< em > In Silico < /em > ADME/Tox Comes of Age: Twenty Years Later
Xenobiotica. 2023 Aug 4:1-11. doi: 10.1080/00498254.2023.2245049. Online ahead of print.ABSTRACTIn the early 2000s pharmaceutical drug discovery was beginning to use computational approaches for absorption, distribution, metabolism, excretion and toxicity (ADME/Tox, also known as ADMET) prediction. This emphasis on prediction was an effort to reduce the risk of later stage failures from ADME/Tox.Much has been written in the intervening twenty plus years and significant expenditure has occurred in companies developing these in silico capabilities which can be gleaned from publications. It is therefore an appropriate time to...
Source: Xenobiotica - August 4, 2023 Category: Research Authors: Sean Ekins Thomas R Lane Fabio Urbina Ana C Puhl Source Type: research
Biochemical responses of the mussel < em > Perna perna < /em > after exposure to environmental concentrations of the UV filter Benzophenone-3
In conclusion, environmentally relevant concentrations of BP-3 altered antioxidant and auxiliary enzymes, which could cause long-term damage to P.perna mussels. The need to implement more efficient techniques in wastewater treatment systems is pointed out, especially in summer, when UV filters are used more frequently and abundantly.PMID:37476967 | DOI:10.1080/00498254.2023.2233022 (Source: Xenobiotica)
Source: Xenobiotica - July 21, 2023 Category: Research Authors: Gabriel S Cruz Juliana R Moser Miguel Salda ña-Serrano Camila L V Bastolla Da ína Lima Carlos H A M Gomes Micheli R de Castro Ucl édia R A Dos Santos Gabriel S Coutinho Jac ó J Mattos Maria R F Marques Source Type: research
Biochemical responses of the mussel < em > Perna perna < /em > after exposure to environmental concentrations of the UV filter Benzophenone-3
In conclusion, environmentally relevant concentrations of BP-3 altered antioxidant and auxiliary enzymes, which could cause long-term damage to P.perna mussels. The need to implement more efficient techniques in wastewater treatment systems is pointed out, especially in summer, when UV filters are used more frequently and abundantly.PMID:37476967 | DOI:10.1080/00498254.2023.2233022 (Source: Xenobiotica)
Source: Xenobiotica - July 21, 2023 Category: Research Authors: Gabriel S Cruz Juliana R Moser Miguel Salda ña-Serrano Camila L V Bastolla Da ína Lima Carlos H A M Gomes Micheli R de Castro Ucl édia R A Dos Santos Gabriel S Coutinho Jac ó J Mattos Maria R F Marques Source Type: research
Biochemical responses of the mussel < em > Perna perna < /em > after exposure to environmental concentrations of the UV filter Benzophenone-3
In conclusion, environmentally relevant concentrations of BP-3 altered antioxidant and auxiliary enzymes, which could cause long-term damage to P.perna mussels. The need to implement more efficient techniques in wastewater treatment systems is pointed out, especially in summer, when UV filters are used more frequently and abundantly.PMID:37476967 | DOI:10.1080/00498254.2023.2233022 (Source: Xenobiotica)
Source: Xenobiotica - July 21, 2023 Category: Research Authors: Gabriel S Cruz Juliana R Moser Miguel Salda ña-Serrano Camila L V Bastolla Da ína Lima Carlos H A M Gomes Micheli R de Castro Ucl édia R A Dos Santos Gabriel S Coutinho Jac ó J Mattos Maria R F Marques Source Type: research
Biochemical responses of the mussel < em > Perna perna < /em > after exposure to environmental concentrations of the UV filter Benzophenone-3
In conclusion, environmentally relevant concentrations of BP-3 altered antioxidant and auxiliary enzymes, which could cause long-term damage to P.perna mussels. The need to implement more efficient techniques in wastewater treatment systems is pointed out, especially in summer, when UV filters are used more frequently and abundantly.PMID:37476967 | DOI:10.1080/00498254.2023.2233022 (Source: Xenobiotica)
Source: Xenobiotica - July 21, 2023 Category: Research Authors: Gabriel S Cruz Juliana R Moser Miguel Salda ña-Serrano Camila L V Bastolla Da ína Lima Carlos H A M Gomes Micheli R de Castro Ucl édia R A Dos Santos Gabriel S Coutinho Jac ó J Mattos Maria R F Marques Source Type: research
