An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS < sup > E < /sup >
Xenobiotica. 2023 Jun 19:1-29. doi: 10.1080/00498254.2023.2227976. Online ahead of print.ABSTRACT1. Compound Kushen injection (CKI) is a kind of sterilized water-soluble traditional Chinese medicine preparation that has been used for the clinical treatment of a variety of cancers (hepatocellular carcinoma, lung cancer, etc.) for nineteen years. However, to date, the metabolism-related study on CKI in vivo has not been conducted.2. An integrated analytical strategy was established to investigate the metabolic profile of alkaloids of CKI in rat plasma, urine and feces based on ultra-high performance liquid chromatography-ele...
Source: Xenobiotica - June 19, 2023 Category: Research Authors: Li Zhang Ruijuan Li Ting Zheng Huan Wu Yanyan Yin Source Type: research
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS < sup > E < /sup >
Xenobiotica. 2023 Jun 19:1-29. doi: 10.1080/00498254.2023.2227976. Online ahead of print.ABSTRACT1. Compound Kushen injection (CKI) is a kind of sterilized water-soluble traditional Chinese medicine preparation that has been used for the clinical treatment of a variety of cancers (hepatocellular carcinoma, lung cancer, etc.) for nineteen years. However, to date, the metabolism-related study on CKI in vivo has not been conducted.2. An integrated analytical strategy was established to investigate the metabolic profile of alkaloids of CKI in rat plasma, urine and feces based on ultra-high performance liquid chromatography-ele...
Source: Xenobiotica - June 19, 2023 Category: Research Authors: Li Zhang Ruijuan Li Ting Zheng Huan Wu Yanyan Yin Source Type: research
An integrated analytical strategy to decipher the metabolic profile of alkaloids in Compound Kushen injection based on UHPLC-ESI-QTOF/MS < sup > E < /sup >
Xenobiotica. 2023 Jun 19:1-29. doi: 10.1080/00498254.2023.2227976. Online ahead of print.ABSTRACT1. Compound Kushen injection (CKI) is a kind of sterilized water-soluble traditional Chinese medicine preparation that has been used for the clinical treatment of a variety of cancers (hepatocellular carcinoma, lung cancer, etc.) for nineteen years. However, to date, the metabolism-related study on CKI in vivo has not been conducted.2. An integrated analytical strategy was established to investigate the metabolic profile of alkaloids of CKI in rat plasma, urine and feces based on ultra-high performance liquid chromatography-ele...
Source: Xenobiotica - June 19, 2023 Category: Research Authors: Li Zhang Ruijuan Li Ting Zheng Huan Wu Yanyan Yin Source Type: research
Meeting report: DMDG peptide and oligonucleotide ADME workshop 2022
Discussion Group) Peptide and Oligonucleotide ADME Workshop 2022 (2nd and 3rd of October 2022). This meeting report summarises the presentations and discussions from this workshop.The following topics were covered:Overview of the drug modality landscapeMetabolism & modellingAnalytical challengesDrug-drug interactions reports from industry working groupsRegulatory interactions.PMID:37309582 | DOI:10.1080/00498254.2023.2223666 (Source: Xenobiotica)
Source: Xenobiotica - June 13, 2023 Category: Research Authors: Jesper Kammersgaard Christensen Inga Bj ørnsdottir Anders Sonesson Steve Hood Source Type: research
Meeting Report: DMDG Peptide and Oligonucleotide ADME Workshop 2022
Discussion Group) Peptide and Oligonucleotide ADME Workshop 2022 (2nd and 3rd of October 2022). This meeting report summarises the presentations and discussions from this workshop.The following topics were covered:Overview of the drug modality landscapeMetabolism & modellingAnalytical challengesDrug-drug interactions reports from industry working groupsRegulatory interactions.PMID:37309582 | DOI:10.1080/00498254.2023.2223666 (Source: Xenobiotica)
Source: Xenobiotica - June 13, 2023 Category: Research Authors: Jesper Kammersgaard Christensen Inga Bj ørnsdottir Anders Sonesson Steve Hood Source Type: research
