Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases
We describe comorbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using the literature, a list of pharmacogenes vital in the response to the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred ...
Source: Topics in HIV Medicine - August 25, 2023 Category: Infectious Diseases Authors: Nyarai Desiree Soko Sarudzai Muyambo Michelle T L Dandara Elizabeth Kampira Dirk Blom Erika S W Jones Brian Rayner Delva Shamley Phumla Sinxadi Collet Dandara Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
Network Visualization Analysis on MicroRNAs in Infectious Diseases Research Area
CONCLUSIONS: Since 2019, the number of studies on miRNA in infectious illnesses has steadily increased. China and the USA have made tremendous contributions to this field's study. We discovered several deregulated miRNAs, including miR-122, miR-133a, miR-146, miR-155, and miR-370, were described in the context of sepsis and infection using bibliometric methods. Understanding these crucial factors, as well as how research is performed and directed, might lead to a new perspective in the creation of new strategies to manage variable infections in the coming years.PMID:37464988 | PMC:PMC10351212 | DOI:10.5001/omj.2023.71 (Sou...
Source: Topics in HIV Medicine - July 19, 2023 Category: Infectious Diseases Authors: Sevil Alkan Mustafa Serhat Şahinoğlu Havva Yasemin Çinpolat Source Type: research
