Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy
Tetrahedron. 2022 Nov 5;126:133071. doi: 10.1016/j.tet.2022.133071. Epub 2022 Oct 5.ABSTRACTCyclic tetrapeptides exhibit high cellular permeability and a wide range of biological properties and thus have gained great interest in the field of medicinal chemistry. We synthesized highly strained 12-membered head to tail cyclic peptides with varying reactive amino acids, without oligomerization using the exclusively intramolecular CyClick chemistry. This occurs by a two-step process involving the low-energy formation of a 15 atom-containing cyclic imine, followed by a chemoselective ring contraction of the peptide backbone gen...
Source: Tetrahedron - November 23, 2023 Category: Chemistry Authors: Rachel Wills Victor Adebomi Caroline Spancake Ryan D Cohen Monika Raj Source Type: research
