Use of unlicensed drugs in a Swiss Pediatric University Hospital and associated prescribing error rates - a retrospective observational study
CONCLUSIONS: Unlicensed drugs are frequently prescribed in this paediatric hospital setting in Switzerland. Around every tenth prescription is an unlicensed drug. Because unlicensed drugs showed a significantly higher rate of prescribing errors, licensed drugs are favourable in terms of medication safety and should be prescribed whenever possible. If no licensed drug is available, imported drugs should be favoured over formula drugs due to lower prescribing error rates. To increase medication safety in paediatrics in Switzerland, efforts are necessary to increase the number of suitable licensed drug formulations for paedia...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Aylin Satir Miriam Pfiffner Christoph R Meier Angela Caduff Good Source Type: research
Changes in diagnostic patterns and resource utilisation in Swiss adult ICUs during the first two COVID-19 waves: an exploratory study
CONCLUSIONS: Based on a comprehensive national data set, our report describes the profound changes triggered by COVID-19 over one year in Swiss ICUs. We observed an overall decrease in admissions and a shift in admission types, with fewer planned hospitalisations, suggesting the loss of approximately 3000 elective interventions. We found a substantial increase in unplanned admissions due to respiratory diagnoses, a doubling of ARDS cases requiring isolation, an increase in ICU LOS associated with substantial nationwide growth in ICU days, an augmented need for life-sustaining therapies and specific therapeutic resources an...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Marco Previsdomini Andreas Perren Alessandro Chiesa Mark Kaufmann Hans Pargger Roger Ludwig Bernard Cerutti Source Type: research
Association between prehospital physician clinical experience and discharge at scene - retrospective cohort study
CONCLUSION: In this retrospective study, there was no association between level of experience and overall rate of discharge at scene. However, greater clinical experience was associated with higher rates of handover to paramedics and less supervision.PMID:38579323 | DOI:10.57187/s.3533 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Romain Betend Laurent Suppan Michele Chan Simon Regard Fran çois Sarasin Christophe A Fehlmann Source Type: research
Therapeutic management of fibrosis in systemic sclerosis patients - an analysis from the Swiss EUSTAR cohort
CONCLUSION: Overall, in Switzerland, a wide range of medications is prescribed for systemic sclerosis patients. This includes modern, targeted treatments for which randomised controlled clinical trial have been recently reported.PMID:38579324 | DOI:10.57187/s.3630 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Kevin Windirsch Suzana Jordan Mike Oliver Becker Cosimo Bruni Rucsandra Dobrota Muriel Elhai Ion-Alexandru Garaiman Carmen-Marina Mihai Michele Iudici Paul Hasler Camillo Ribi Britta Maurer Armando Gabrielli Anna-Maria Hoffmann-Vold Oliver Distler Source Type: research
Long-term course of neutralising antibodies against SARS-CoV-2 in vaccinated and unvaccinated staff and residents in a Swiss nursing home: a cohort study 2021-2022
CONCLUSIONS: Our study of the long-term serological course of SARS-CoV-2 in a nursing home showed that the first SARS-CoV-2 booster vaccine was essential for maintaining antiviral antibody levels. Hybrid immunity sustained SARS-CoV-2 immunity at the highest level. In critical settings such as nursing homes, monitoring the SARS-CoV-2 immune status may guide booster vaccinations.PMID:38579325 | DOI:10.57187/s.3502 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Lisa Perrig Irene A Abela Nicolas Banholzer Annette Audig é Selina Epp Catrina Mugglin Kathrin Z ürcher Matthias Egger Alexandra Trkola Lukas Fenner Source Type: research
Genomic characteristics of clinical non-toxigenic Vibrio cholerae isolates in Switzerland: a cross-sectional study
CONCLUSIONS: V. cholerae infections in Switzerland are rare and predominantly caused by lowly virulent ctxAB-negative and tcpA-negative strains. As V. cholerae is not endemic in Switzerland, cases are assumed to be acquired predominantly during travel. This assumption was supported by the phylogenetic diversity of the analysed isolates.PMID:38579327 | DOI:10.57187/s.3437 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Natalie Meyer Roger Stephan Nicole Cernela Jule Anna Horlbog Michael Biggel Source Type: research
National survey in Switzerland calls for improved diagnosis and treatment in children with scabies
CONCLUSION: In Switzerland, scabies is a frequent dermatosis in migrant and Swiss children. While accessible, optimal diagnostics are underutilised, and treatment is suboptimal. Permethrin resistance appears to be an increasing problem. Dermatologists regularly use ivermectin off-label in children weighing <15 kg. Treatment studies on ivermectin use in children weighing <15 kg, user-friendly diagnostic tools, new treatment protocols, and child-friendly dosage forms are needed to improve the diagnosis and treatment of children with scabies.PMID:38579328 | DOI:10.57187/smw.2023.40129 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Michael Buettcher Anita K Stebler Martin Theiler Kevin Kobylinski Marc Pfister Source Type: research
What are the bottlenecks to health data sharing in Switzerland? An interview study
CONCLUSIONS: Facilitating a data access culture in Switzerland may require legal clarifications, further education about the process and resources to support data sharing, and further investment in sustainable infrastructureby funders and institutions.PMID:38579329 | DOI:10.57187/s.3538 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Kelly E Ormond Sabine Bavamian Claudia Becherer Christine Currat Francisca Joerger Thomas R Geiger Elke Hiendlmeyer Julia Maurer Timo Staub Effy Vayena Source Type: research
Who was at risk of trauma-related injuries during the COVID-19 pandemic? A retrospective study from a level 1 trauma centre in Switzerland
CONCLUSION: This study described changes in trauma patterns and highlighted populations at risk of trauma during the pandemic in Switzerland in the context of previous international studies.These results may contribute to resource management in a future pandemic.PMID:38579330 | DOI:10.57187/s.3539 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Till Flury Jo ël Gerber Helen Anwander Martin M üller Dominik A Jakob Aristomenis Exadaktylos Karsten Klingberg Source Type: research
Introducing "opt out" organ donation in Switzerland: lessons from the UK experience
Swiss Med Wkly. 2024 Mar 4;154:3572. doi: 10.57187/s.3572.NO ABSTRACTPMID:38579331 | DOI:10.57187/s.3572 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Jordan A Parsons Source Type: research
Mid- to long-term cardiac magnetic resonance findings in elite athletes recovered from COVID-19: results from an ongoing observational COVID-19 study at a German Olympic medical centre
CONCLUSION: Our findings suggest that the risk for mid- to long-term myocardial damage is very low to negligible in elite athletes. Our results do not allow conclusions to be drawn regarding myocardial injury in the acute phase of infection nor about possible long-term myocardial effects in the general population.PMID:38579332 | DOI:10.57187/s.3534 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Christopher Schneeweis Katharina Diebold Thomas Schramm Christine Syrek Hans-Georg Predel Robert Manka Jonas Zacher Source Type: research
Supplementum 275: Abstracts of the 55th Annual meeting of the Swiss Society of Nephrology
Swiss Med Wkly. 2023 Nov 30;154:3671. doi: 10.57187/s.3671.NO ABSTRACTPMID:38579333 | DOI:10.57187/s.3671 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: None Swiss Society Of Nephrology Source Type: research
Pembrolizumab-associated anti-MDA5 dermatomyositis in a patient with lung cancer: a first case report
We report the first case of anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis as a systemic immune-related adverse event in a 64-year-old man receiving pembrolizumab to treat advanced lung cancer. The patient experienced hypothyroidism, myalgia, skin involvement, dyspnoea and diarrhoea. Laboratory tests revealed raised inflammatory markers, hypercreatinekinasemia and anti-MDA5 autoantibodies. Electroneuromyography and pathognomonic signs on physical examination confirmed the diagnosis of pauci-myopathic dermatomyositis. Pembrolizumab was discontinued and immunosuppressive therapy led to rapid ...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Antonino Marcello Pilia Lorenzo Salvati Alessia Guidolin Francesca Mazzoni Lorenzo Antonuzzo Paola Parronchi Francesco Liotta Source Type: research
Impact on diabetes control and patient-reported outcomes of a newer implantable continuous glucose monitoring system (Eversense ® CGM System): a single-centre retro- and prospective observational study
CONCLUSIONS: The use of the Eversense® CGM System resulted in changes in HbA1c of between -0.2% and -0.45%. The rate of premature sensor breakdown was low. Major complications following sensor implantation or removal were absent, apart from one case of infection and four cases of complicated removal. Patient-reported outcomes with the Eversense® CGM System showed a subjective positive impact on hypoglycaemia rates, greater confidence in managing hypoglycaemia and diabetes in general, and easy handling of the transmitter and mobile app. Technical issues must be considered but are nowadays, with the use of the newest senso...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: None Dimitri Guy Rohner None Lukas Burget None Christoph Henzen None Stefan Fischli Source Type: research
Clinical reasoning for the continuation or discontinuation of hip precautions after total hip arthroplasty in Switzerland: a qualitative study
CONCLUSION: A lack of clear instructions from the surgeon leads to ambiguity among therapists outside the acute hospital. A shared understanding of the need for and nature of hip precautions, guidelines from societies, or at least specific instructions from surgeons to therapists are warranted.PMID:38579291 | DOI:10.57187/s.3536 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Jaroslaw Krygowski Leah Reicherzer Thimo Marcin Source Type: research
