The magnitude of the plasma hepcidin response to oral iron supplements depends on the iron dosage
CONCLUSION: We found a dose-dependent effect of iron supplementation on plasma hepcidin levels. Lower iron dosage results in a smaller increase in hepcidin and might thus lead to more efficient intestinal iron absorption and fewer side effects. The effectiveness and side effects of low-dose iron treatment in women with iron deficiency should be further investigated. This study was registered at the Swiss National Clinical Trials Portal (2021-00312) and ClinicalTrials.gov (NCT04735848).PMID:38579297 | DOI:10.57187/s.3635 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Maximilian Karczewski Stana Simic Lanja Saleh Albina Nowak Morton G Schubert Diego Moretti Dorine W Swinkels Felix Beuschlein Paolo M Suter Pierre-Alexandre Krayenbuehl Source Type: research
Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database
CONCLUSION: In Switzerland, metamizole was increasingly claimed between 2014 and 2019. Metamizole was most frequently claimed by older adults and patients with comedications suggestive of underlying conditions, which can be worsened or caused by use of nonsteroidal anti-inflammatory drugs. The lack of studies regarding the effectiveness and safety of metamizole in this population warrants further investigation.PMID:38579298 | DOI:10.57187/s.3535 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Stephan Gut Marlene Rauch Manuel Haschke Carola A Huber Jan Gaertner Nadine Schur Christoph R Meier Julia Spoendlin Source Type: research
Post-transplant survival with pre-transplant durable continuous-flow mechanical circulatory support in a Swiss cohort of heart transplant recipients
CONCLUSION: This data indicates that the strategy of pre-transplant CF-MCS with subsequent orthotopic heart transplantation provides post-transplant outcomes not different to direct heart transplantation despite the fact that the duration of pre-transplant assist device treatment has progressively increased.PMID:38579299 | DOI:10.57187/s.3500 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Roger Hullin Tamila Abdurashidova Barbara Pitta-Gros Sara Schukraft Valentina Rancati Henri Lu Anouck Zurbuchen Carlo Marcucci Zied Ltaief Karl Lefol Christoph Huber Manuel Pascual Piergiorgio Tozzi Philippe Meyer Matthias Kirsch Source Type: research
An in-hospital intervention to reduce the proportion of misused inhalers at hospital discharge among patients with COPD: a non-randomised intervention study
CONCLUSIONS: An in-hospital intervention was associated with a reduction in the proportion of misused inhalers at hospital discharge. This intervention should be considered for hospitalised patients with COPD. The trial was registered with ClinicalTrials.gov (NCT05207631).PMID:38579300 | DOI:10.57187/s.3394 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Gael Grandmaison Thomas Grob éty Philippe Dumont Julien Vaucher Daniel Hayoz Philipp Suter Source Type: research
Transdisciplinary sarcoma care: a model for sustainable healthcare transformation
Swiss Med Wkly. 2024 Apr 4;154:3473. doi: 10.57187/s.3473.NO ABSTRACTPMID:38579301 | DOI:10.57187/s.3473 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Bruno Fuchs Beata Bode Philip Heesen Barbara Kopf Christian Michelitsch Manfred Odermatt Pietro Giovanoli Stefan Breitenstein Paul Schneider Guido Sch üpfer Stefan Boes Gabriela Studer Source Type: research
Use of complementary medicine and its association with SARS-CoV-2 vaccination during the COVID-19 pandemic: a longitudinal cohort study
CONCLUSION: While complementary medicine is increasingly used, it is rarely discussed with primary care physicians. Complementary medicine use, especially for COVID-19 prevention, is associated with COVID-19 vaccination status. Communication between physicians, patients, and complementary medicine therapists is encouraged to facilitate a truly holistic approach to making a shared decision based on the best available information.PMID:38579302 | DOI:10.57187/s.3505 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Mayssam Nehme Olivia Braillard Pierre-Yves Rodondi Idris Guessous Source Type: research
Prognostic impact of carotid plaque imaging using total plaque area added to SCORE2 in middle-aged subjects: the ARteris Cardiovascular Outcome (ARCO) cohort study
CONCLUSIONS: Integration of TPA post-test risk into SCORE2 adds prognostic information, supporting the use of carotid ultrasound when assessing ASCVD risk in subjects aged 40-65 years.PMID:38579303 | DOI:10.57187/s.3735 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Michel Romanens Ansgar Adams Michel Wenger Walter Warmuth Isabella Sudano Source Type: research
Glycaemic outcomes in adults with type 1 diabetes transitioning towards advanced automated insulin delivery systems - a real-world analysis at a Swiss tertiary centre
CONCLUSIONS: Glucose levels significantly improved when transitioning from a (P)LGS to a hybrid-closed loop. Glucose levels improved further when switching from a hybrid-closed loop to an advanced hybrid-closed loop. However, the added benefit of an advanced hybrid-closed loop was comparably smaller. This pattern was also reflected in the subgroup analysis.PMID:38579305 | DOI:10.57187/s.3501 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Vera Lehmann Franco Noti Markus Laimer Christoph Stettler Thomas Z üger Source Type: research
Historic characteristics and mortality of patients in the Swiss Amyloidosis Registry
CONCLUSION: During registry set-up, a more comprehensive work-up of our patients suffering mainly from light-chain amyloidosis and transthyretin amyloidosis was implemented. Survival rates were remarkably high and similar between light-chain amyloidosis and transthyretin amyloidosis, a finding which was noted in similar historic registries of international centres. However, further studies are needed to depict morbidity and mortality as the amyloidosis landscape is changing rapidly.PMID:38579306 | DOI:10.57187/s.3485 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Sofie Brouwers Raphael Heimgartner Natallia Laptseva Adriano Aguzzi Niklas F Ehl Thomas Fehr Felicitas Hitz Hans H Jung Joel K älin Markus G Manz Beat M üllhaupt Frank Ruschitzka Harald Seeger Georg Stussi Markus Zweier Andreas J Flammer Bernhard Gerber Source Type: research
Palliative sedation - revised recommendations
Swiss Med Wkly. 2024 Feb 15;154:3590. doi: 10.57187/s.3590.ABSTRACTPalliative sedation is defined as the monitored use of medications intended to induce a state of decreased or absent awareness (unconsciousness) to relieve the burden of otherwise intractable suffering in a manner ethically acceptable to the patient, their family, and healthcare providers. In Switzerland, the prevalence of continuous deep sedation until death increased from 4.7% in 2001 to 17.5% of all deceased in 2013, depending on the research method used and on regional variations. Yet, these numbers may be overestimated due to a lack of understanding of...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Michel Beauverd Marta Mazzoli Josiane Pralong Martyna Tomczyk Steffen Eychm üller Jan Gaertner Source Type: research
An economic evaluation of an early palliative care intervention among patients with advanced cancer
CONCLUSION: Although early palliative care is often presented as a cost-reducing care service, we could not show a significant effect of the SENS intervention on health care utilisation and costs in the last month of life. However, it may be that the intervention was not intensive enough, the timeframe too short or the study population too small for measurable effects. Patients appreciated the intervention. Single-structured early palliative care interventions are easy to implement in clinical practice and present low treatment costs. Further research about the economic impact of early palliative care should focus on extra...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Maud Maessen Monica C Fliedner Brigitta Gahl Marina Maier Daniel M Aebersold Susanne Zwahlen Steffen Eychm üller Source Type: research
Investigations of an increased incidence of non-Aspergillus invasive mould infections in an onco-haematology unit
CONCLUSIONS: We report a significant increase in non-Aspergillus mould infections, and mainly in mucormycosis infections, since 2017. There seems to be a multifactorial origin to this increase. Epidemiological trends of invasive mould infections should be carefully monitored in onco-haematology units in order to implement potential corrective measures.PMID:38579310 | DOI:10.57187/s.3730 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Elisavet Stavropoulou Anne Huguenin Giorgia Caruana Onya Opota Nancy Perrottet Dominique S Blanc Bruno Grandbastien Laurence Senn Pierre-Yves Bochud Frederic Lamoth Source Type: research
Stepwise implementation of an enhanced recovery pathway for elective total hip arthroplasty in a Swiss hospital: a cohort study
CONCLUSIONS: Almost all parameters examined in this study showed improvement, whereas the rate of adverse events was not affected and remained low. The presented data can be used as a benchmark, but details of these findings need to be confirmed in larger cohorts.PMID:38579311 | DOI:10.57187/s.3537 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Simon Heinrich Simon Gratza Anke Eckardt Thomas Ilchmann Source Type: research
A cohort study of patients hospitalised with SARS-CoV-2 infection in Ontario: patient characteristics and outcomes by wave
CONCLUSION: Throughout the pandemic, sociodemographic characteristics of patients hospitalised with SARS-CoV-2 changed over time, particularly in terms of ethnic diversity, but still disproportionately affected patients from more marginalised regions. Improved survival and reduced use of critical care during the Omicron wave are reassuring.PMID:38579312 | DOI:10.57187/s.3636 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Steven Habbous Anna Lambrinos Kirsten Ming Erik Hellsten Source Type: research
Evaluation of a surveillance system for Clostridioides difficile infections for Swiss hospitals
CONCLUSION: This study underscores the importance of a joint effort towards standardized surveillance practices in providing comprehensive insights into C. difficile infection epidemiology and effective prevention strategies in Swiss healthcare settings. The patient-related approach remains the gold standard for C. difficile infection surveillance, although it demands substantial resources and provides results only annually. The proposed implementation of nationwide automated laboratory-based surveillance would be pragmatic and efficient, empowering authorities and hospitals to detect outbreaks promptly and to correlate in...
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Ana Durovic Alexandra Ursula Scherrer David Widmer Andreas F Widmer Source Type: research
