Bioinformatics-based identification of key candidate genes and signaling pathways in patients with Parkinson's disease and obstructive sleep apnea
CONCLUSION: Our findings suggest that CADPS, CHGA, and SCG3 are key genes involved in molecular mechanisms underlying interactions between OSA and PD. Functional enrichment of hub genes indicated a link between GABAergic synapses and the shared pathogenesis of PD and OSA. These candidate genes and corresponding pathways offer novel insights regarding biological targets that underlie the transcriptional connection between OSA and PD.PMID:38316731 | DOI:10.1007/s11325-024-03003-6 (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 5, 2024 Category: Sleep Medicine Authors: Huan Tang Kejia Zhang Chi Zhang Kai Zheng Luying Gui Bin Yan Source Type: research
How do phases of the menstrual cycle affect sleep? A polysomnographic study of the EPISONO database
ConclusionsOur findings demonstrate that the mid/late follicular phase might be beneficial for women ’s sleep, although there were no statistically changes in inflammatory mediators among the groups. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 5, 2024 Category: Respiratory Medicine Source Type: research
Bioinformatics-based identification of key candidate genes and signaling pathways in patients with Parkinson ’s disease and obstructive sleep apnea
ConclusionOur findings suggest that CADPS, CHGA, and SCG3 are key genes involved in molecular mechanisms underlying interactions between OSA and PD. Functional enrichment of hub genes indicated a link between GABAergic synapses and the shared pathogenesis of PD and OSA. These candidate genes and corresponding pathways offer novel insights regarding biological targets that underlie the transcriptional connection between OSA and PD. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 5, 2024 Category: Respiratory Medicine Source Type: research
How do phases of the menstrual cycle affect sleep? A polysomnographic study of the EPISONO database
ConclusionsOur findings demonstrate that the mid/late follicular phase might be beneficial for women ’s sleep, although there were no statistically changes in inflammatory mediators among the groups. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 5, 2024 Category: Respiratory Medicine Source Type: research
Bioinformatics-based identification of key candidate genes and signaling pathways in patients with Parkinson ’s disease and obstructive sleep apnea
ConclusionOur findings suggest that CADPS, CHGA, and SCG3 are key genes involved in molecular mechanisms underlying interactions between OSA and PD. Functional enrichment of hub genes indicated a link between GABAergic synapses and the shared pathogenesis of PD and OSA. These candidate genes and corresponding pathways offer novel insights regarding biological targets that underlie the transcriptional connection between OSA and PD. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 5, 2024 Category: Respiratory Medicine Source Type: research
Obstructive sleep apnea affects cognition: dual effects of intermittent hypoxia on neurons
Sleep Breath. 2024 Feb 3. doi: 10.1007/s11325-024-03001-8. Online ahead of print.ABSTRACTObstructive sleep apnea (OSA) is a common respiratory disorder. Multiple organs, especially the central nervous system (CNS), are damaged, and dysfunctional when intermittent hypoxia (IH) occurs during sleep for a long time. The quality of life of individuals with OSA is significantly impacted by cognitive decline, which also escalates the financial strain on their families. Consequently, the development of novel therapies becomes imperative. IH induces oxidative stress, endoplasmic reticulum stress, iron deposition, and neuroinflammat...
Source: Sleep and Breathing - February 3, 2024 Category: Sleep Medicine Authors: Yao He Na Dong Xiao Wang Ren-Jun Lv Qin Yu Hong-Mei Yue Source Type: research
Implications of obstructive sleep apnea on reproductive health: a study on anti-Mullerian hormone levels
CONCLUSION: OSA may have potential endocrine implications, especially concerning reproductive health. Decreased AMH levels in OSA patients could indicate future risks of infertility or early menopause.PMID:38308749 | DOI:10.1007/s11325-024-02998-2 (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Sleep Medicine Authors: Hanifi Yildiz Hamit Hakan Alp R ıfkı Üçler Mehmet Hakan Bilgin Source Type: research
The prevalence and polysomnographic characteristics of treatment-emergent central sleep apnea with obstructive sleep apnea
CONCLUSION: TECSA is a phenomenon that can occur with obstructive sleep apnea treatment and mostly regress spontaneously following appropriate CPAP treatment. TECSA is observed at different rates of prevalence. In this study, the prevalence of TECSA was higher than previously reported.PMID:38308750 | DOI:10.1007/s11325-024-02999-1 (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Sleep Medicine Authors: Sinem Berik Saf çi Source Type: research
Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism
CONCLUSION: There was a Th17/Treg imbalance in OSA patients. The prediction of Th17 and Treg cell proportions in OSA can be facilitated by AHI, as well as serum IL-6, TGF-β1, and HIF-1α levels. Furthermore, CPAP treatment can potentially improve the Th17/Treg imbalance and reduce proinflammatory cytokines in OSA patients.PMID:38308751 | DOI:10.1007/s11325-024-02997-3 (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Sleep Medicine Authors: Chong Shen Dandan Zong Yating Peng Li Zhou Ting Liu Ruoyun Ouyang Source Type: research
Relationship between sleep quality and gravitational Tolerance
CONCLUSION: In conclusion, participants with good sleep quality were 4.705 times more likely to have longer G-tolerance test time. Thus, it is important for aircraft pilots to manage their sleep quality. Pre-pilots should also improve their sleep quality to pass the G-tolerance test.PMID:38308752 | DOI:10.1007/s11325-023-02987-x (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Sleep Medicine Authors: Deokhwa Jeong Eunjae Lee Junyoung Sung Sunghwun Kang Source Type: research
Implications of obstructive sleep apnea on reproductive health: a study on anti-Mullerian hormone levels
ConclusionOSA may have potential endocrine implications, especially concerning reproductive health. Decreased AMH levels in OSA patients could indicate future risks of infertility or early menopause. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Respiratory Medicine Source Type: research
Relationship between sleep quality and gravitational Tolerance
ConclusionIn conclusion, participants with good sleep quality were 4.705 times more likely to have longer G-tolerance test time. Thus, it is important for aircraft pilots to manage their sleep quality. Pre-pilots should also improve their sleep quality to pass the G-tolerance test. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Respiratory Medicine Source Type: research
Effect of continuous positive airway pressure treatment on Th17/Treg imbalance in patients with obstructive sleep apnea and a preliminary study on its mechanism
ConclusionThere was a Th17/Treg imbalance in OSA patients. The prediction of Th17 and Treg cell proportions in OSA can be facilitated by AHI, as well as serum IL-6, TGF- β1, and HIF-1α levels. Furthermore, CPAP treatment can potentially improve the Th17/Treg imbalance and reduce proinflammatory cytokines in OSA patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Respiratory Medicine Source Type: research
Obstructive sleep apnea affects cognition: dual effects of intermittent hypoxia on neurons
AbstractObstructive sleep apnea (OSA) is a common respiratory disorder. Multiple organs, especially the central nervous system (CNS), are damaged, and dysfunctional when intermittent hypoxia (IH) occurs during sleep for a long time. The quality of life of individuals with OSA is significantly impacted by cognitive decline, which also escalates the financial strain on their families. Consequently, the development of novel therapies becomes imperative. IH induces oxidative stress, endoplasmic reticulum stress, iron deposition, and neuroinflammation in neurons. Synaptic dysfunction, reactive gliosis, apoptosis, neuroinflammat...
Source: Sleep and Breathing - February 3, 2024 Category: Respiratory Medicine Source Type: research
The prevalence and polysomnographic characteristics of treatment-emergent central sleep apnea with obstructive sleep apnea
ConclusionTECSA is a phenomenon that can occur with obstructive sleep apnea treatment and mostly regress spontaneously following appropriate CPAP treatment. TECSA is observed at different rates of prevalence. In this study, the prevalence of TECSA was higher than previously reported. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 3, 2024 Category: Respiratory Medicine Source Type: research
