Serum Levels of Branched Chain Amino Acids Predict Duration of Cardiovascular Organ Failure in Septic Shock
Conclusions:
Among patients with septic shock, BCAA concentrations independently predict time to shock resolution. This study provides hypothesis generating data into the potential contribution of BCAAs to the pathophysiology of cardiovascular failure in sepsis, opening areas for future investigations. (Source: Shock)
Source: Shock - July 1, 2021 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research
Temporal Differential Expression of Physiomarkers Predicts Sepsis in Critically Ill Adults
Conclusions:
This study demonstrates that salient physiomarkers derived from continuous bedside monitoring are temporally and differentially expressed in septic patients. Using this information, minimalistic artificial intelligence models can be developed to predict sepsis earlier in critically ill patients. (Source: Shock)
Source: Shock - July 1, 2021 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research
Effect of Early Central Venous Catheterization on Mortality Among Patients with Severe Sepsis: A Nationwide Inpatient Database Study
Conclusions:
Among patients with severe sepsis, early CVC was not associated with improved in-hospital mortality rates. (Source: Shock)
Source: Shock - July 1, 2021 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research
Complications of Hemorrhagic Shock and Massive Transfusion—a Comparison Before and After the Damage Control Resuscitation Era
Trauma remains a leading cause of death, and hemorrhage is the leading cause of preventable trauma deaths. Resuscitation strategies in trauma have changed dramatically over the last 20 years. In the pre damage control resuscitation (DCR) era, we used large volume crystalloid resuscitation and packed red blood cells as the primary resuscitative fluids. Now, a 1:1:1 ratio of packed red blood cells, fresh plasma, and platelets with minimal crystalloids is the preferred resuscitative strategy (DCR era). As we have changed how we resuscitate patients, the detrimental effects associated with large volume resuscitation have also ...
Source: Shock - July 1, 2021 Category: Emergency Medicine Tags: Review Articles Source Type: research
The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury, and Sepsis: A Review of Pathophysiology
Hematopoietic stem/progenitor cells (HSPC) have both unique and common responses following hemorrhage, injury, and sepsis. HSPCs from different lineages have a distinctive response to these “stress” signals. Inflammation, via the production of inflammatory factors, including cytokines, hormones, and interferons, has been demonstrated to impact the differentiation and function of HSPCs. In response to injury, hemorrhagic shock, and sepsis, cellular phenotypic changes and altered function occur, demonstrating the rapid response and potential adaptability of bone marrow hematopoietic cells. In this review, we summarize th...
Source: Shock - July 1, 2021 Category: Emergency Medicine Tags: Review Articles Source Type: research
