Seminars in Respiratory and Critical Care Medicine Seminars in Respiratory and Critical Care Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Lung Allocation Score and Its Relevance
Semin Respir Crit Care Med 2021; 42: 346-356 DOI: 10.1055/s-0041-1729541Lung transplantation in the United States, under oversight by the Organ Procurement Transplantation Network (OPTN) in the 1990s, operated under a system of allocation based on location within geographic donor service areas, wait time of potential recipients, and ABO compatibility. On May 4, 2005, the lung allocation score (LAS) was implemented by the OPTN Thoracic Organ Transplantation Committee to prioritize patients on the wait list based on a balance of wait list mortality and posttransplant survival, thus eliminating time on the wait list as a fact...
Source: Seminars in Respiratory and Critical Care Medicine - May 24, 2021 Category: Respiratory Medicine Authors: Lyu, Dennis M. Goff, Rebecca R. Chan, Kevin M. Tags: Review Article Source Type: research

Selection Criteria for Lung Transplantation: Controversies and New Developments
Semin Respir Crit Care Med 2021; 42: 329-345 DOI: 10.1055/s-0041-1728756Lung transplantation is an accepted therapeutic option for end-stage lung diseases. The imbalance between limited availability and vast need of donor organs necessitates careful selection of recipient candidates, ensuring the best possible utilization of the scarce resource of organs. Nonetheless, possible lung transplant candidates who could experience a meaningful improvement in survival and quality of life should not be excluded solely based on the complexity of their case. In this review, controversial issues or difficult limitations for lung trans...
Source: Seminars in Respiratory and Critical Care Medicine - May 24, 2021 Category: Respiratory Medicine Authors: Beeckmans, Hanne Bos, Saskia Vos, Robin Tags: Review Article Source Type: research

Lung Transplantation: Controversies and Evolving Concepts
Semin Respir Crit Care Med 2021; 42: 327-328 DOI: 10.1055/s-0041-1728793 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - May 24, 2021 Category: Respiratory Medicine Authors: Belperio, John A. Palmer, Scott M. Tags: Preface Source Type: research

The Diagnosis and Management of Acute Pulmonary Embolism in 2021: Evolving Strategies
Semin Respir Crit Care Med 2021; 42: 169-170 DOI: 10.1055/s-0041-1725058 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - March 30, 2021 Category: Respiratory Medicine Authors: Tapson, Victor F. Tags: Preface Source Type: research

Trends in Mortality of Acute Pulmonary Embolism
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1725059Despite substantial advances in the diagnosis and management, pulmonary embolism (PE) continues to be a significant cause of mortality. In this article, we provide a concise overview of the evolution of worldwide mortality trends related to PE. Despite the data being derived mainly from observational studies, there is a clear trend toward decreasing mortality over time from PE. Whether this truly represents a treatment effect or is more related to increased diagnosis of small PEs is not fully clear. Modern approaches to PE management such as the PE response teams have t...
Source: Seminars in Respiratory and Critical Care Medicine - March 10, 2021 Category: Respiratory Medicine Authors: Ho, An Thi Nhat Bellamy, Nelly Naydenov, Soophia K. Tags: Review Article Source Type: research

Venous Thromboembolism: Genetics and Thrombophilias
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1723937Venous thromboembolism (VTE) is a major cause of morbidity and mortality throughout the world. Up to one half of patients who present with VTE will have an underlying thrombophilic defect. This knowledge has led to a widespread practice of testing for such defects in patients who develop VTE. However, identifying a hereditary thrombophilia by itself does not necessarily change outcomes or dictate therapy. Furthermore, family history of VTE by itself can increase an asymptomatic person's VTE risk several-fold, independent of detecting a known inherited thrombophilia. In ...
Source: Seminars in Respiratory and Critical Care Medicine - March 10, 2021 Category: Respiratory Medicine Authors: Gaddh, Manila Rosovsky, Rachel P. Tags: Review Article Source Type: research

Advances in the Management of Acute Venous Thromboembolism and New Therapeutic Agents
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1723953Important advances in the understanding and management of venous thromboembolism (VTE) have enhanced our ability to diagnose, prevent, and treat VTE. In this narrative review, we discuss how recent advances in the understanding and management of VTE are changing practice, highlight ongoing unmet needs in VTE management, and outline how novel therapeutic targets with little or no influence on hemostasis may help address these unmet needs. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of con...
Source: Seminars in Respiratory and Critical Care Medicine - February 18, 2021 Category: Respiratory Medicine Authors: Stevens, Hannah McFadyen, James Chan, Noel Tags: Review Article Source Type: research

Direct Oral Anticoagulants in the Treatment of Venous Thromboembolism: Use in Patients with Advanced Renal Impairment, Obesity, or Other Weight-Related Special Populations
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1723952There are currently more than 7 million patients taking a direct oral anticoagulant (DOAC), with more new prescriptions per year than warfarin. Despite impressive efficacy and safety data for the treatment of venous thromboembolism, patients with obesity or advanced renal impairment represented a small portion of the patients enrolled in the phase 3 clinical trials. Therefore, to evaluate the potential use of DOACs in these special populations, clinicians need to have an understanding of the pharmacokinetics and pharmacodynamics of these agents in these settings. Since ...
Source: Seminars in Respiratory and Critical Care Medicine - February 18, 2021 Category: Respiratory Medicine Authors: Dobesh, Paul P. Kernan, Molly M. Lueshen, Jenni J. Tags: Review Article Source Type: research

High-Risk Pulmonary Embolism: Embolectomy and Extracorporeal Membrane Oxygenation
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1722868Pulmonary embolism (PE) is a common medical condition associated with significant morbidity and mortality. It is the third most common cause of death in the United States. Historically, surgery for PE was associated with a high mortality rate, and this led to a significant decrease in the volume of operations being performed. However, significant improvements in patient selection and outcomes for surgical pulmonary embolectomy (SPE) at the end of the 20th century led to a renewed interest in the procedure. SPE was historically reserved for patients presenting with acute...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2021 Category: Respiratory Medicine Authors: Murray, John L. Zapata, David Keeling, William B. Tags: Review Article Source Type: research

Suspected Acute Pulmonary Embolism: Gestalt, Scoring Systems, and Artificial Intelligence
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1723936Pulmonary embolism (PE) remains a diagnostic challenge in 2021. As the pathology is potentially fatal and signs and symptoms are nonspecific, further investigations are classically required. Based on the Bayesian approach, clinical probability became the keystone of the diagnostic strategy to rule out PE in the case of a negative testing. Several clinical probability assessment methods are validated: gestalt, the Wells score, or the revised Geneva score. While the debate persists as to the best way to assess clinical probability, its assessment allows for the good inter...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2021 Category: Respiratory Medicine Authors: Douillet, Delphine Roy, Pierre-Marie Penaloza, Andrea Tags: Review Article Source Type: research

The Pulmonary Embolism Response Team: Why and How?
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1722963Treatment of patients with intermediate and high-risk pulmonary embolism (PE) is a controversial area. Many therapeutic options exist, and deciding on appropriate treatment can be difficult. In addition, multiple specialties are often involved in the care of PE patients. To better organize the response to serious PE patients, several hospitals and academic centers throughout the world have created pulmonary embolism response teams (PERTs). The goal of a PERT is to have a single multidisciplinary team of experts in thromboembolic disease, who can respond rapidly to patie...
Source: Seminars in Respiratory and Critical Care Medicine - February 16, 2021 Category: Respiratory Medicine Authors: Channick, Richard N. Tags: Review Article Source Type: research

Risk Stratification in Acute Pulmonary Embolism: The Latest Algorithms
Semin Respir Crit Care Med DOI: 10.1055/s-0041-1722898Pulmonary embolism (PE) is a common clinical entity, which most clinicians will encounter. Appropriate risk stratification of patients is key to identify those who may benefit from reperfusion therapy. The first step in risk assessment should be the identification of hemodynamic instability and, if present, urgent patient consideration for systemic thrombolytics. In the absence of shock, there is a plethora of imaging studies, biochemical markers, and clinical scores that can be used to further assess the patients' short-term mortality risk. Integrated prediction models...
Source: Seminars in Respiratory and Critical Care Medicine - February 6, 2021 Category: Respiratory Medicine Authors: Triantafyllou, Georgios A. O'Corragain, Oisin Rivera-Lebron, Belinda Rali, Parth Tags: Review Article Source Type: research

Aggressive Therapy for Acute Pulmonary Embolism: Systemic Thrombolysis and Catheter-Directed Approaches
This article reviews current clinical evidence and societal guidelines for the use of systemic and catheter-directed thrombolysis for treatment of acute PE. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - February 6, 2021 Category: Respiratory Medicine Authors: Todoran, Thomas M. Petkovich, Bradley Tags: Review Article Source Type: research

Evaluating the Right Ventricle in Acute and Chronic Pulmonary Embolism: Current and Future Considerations
Semin Respir Crit Care Med DOI: 10.1055/s-0040-1722290The right ventricle (RV), due to its morphologic and physiologic differences, is susceptible to sudden increase in RV afterload, as noted in patients with acute pulmonary embolism (PE). Functional impairment of RV function is a stronger presage of adverse outcomes in acute PE than the location or burden of emboli. While current iterations of most clinical prognostic scores do not incorporate RV dysfunction, advancements in imaging have enabled more granular and accurate assessment of RV dysfunction in acute PE. RV enlargement and dysfunction on imaging is noted only in ...
Source: Seminars in Respiratory and Critical Care Medicine - February 6, 2021 Category: Respiratory Medicine Authors: Singh, Siddharth Lewis, Michael I. Tags: Review Article Source Type: research

Prevention of Venous Thromboembolism in Acutely Ill Medical Patients: A New Era
This article aims to review the latest concepts in predicting and preventing VTE and discuss the new era of extended thromboprophylaxis in hospitalized medically ill patients. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - February 6, 2021 Category: Respiratory Medicine Authors: MacDougall, Kira Spyropoulos, Alex C. Tags: Review Article Source Type: research