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Comprehensive genomic analysis of puerarin in inhibiting bladder urothelial carcinoma cell proliferation and migration
CONCLUSION: Our findings support the potential antitumor activity of puerarin in BUC. To the best of our knowledge, bioinformatics investigation suggests that puerarin demonstrates anticancer mechanisms via the upregulation of ITGA1, LAMA3 and 4, LAMB3, PAK2, DMD, and UTRN, all of which are involved in the proliferation and migration of bladder urothelial cancer cells.PMID:37694778 | DOI:10.2174/1574892819666230908110107 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - September 11, 2023 Category: Cancer & Oncology Authors: Yu-Yang Ma Ge-Jin Zhang Peng-Fei Liu Ying Liu Ji-Cun Ding Hao Xu Lin Hao Deng Pan Hai-Luo Wang Jing-Kai Wang Peng Xu Zhen-Duo Shi Kun Pang Source Type: research

Fatty Acid Metabolism Signature Contributes to the Molecular Diagnosis of a Malignant Gastric Cancer Subtype with Poor Prognosis and Lower Mutation Burden
CONCLUSION: Fatty acid metabolism genes affect the development of gastric adenocarcinoma and can predict the survival prognosis, tumor mutational load characteristics, and drug therapy sensitivity of STAD patients, which can help explore more effective immunotherapy targets for GC.PMID:37691229 | DOI:10.2174/1574892819666230907145036 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - September 11, 2023 Category: Cancer & Oncology Authors: Zhengwei Chen Guoxiong Cheng Source Type: research

Integrating Bioinformatics and Drug Sensitivity Analyses to Identify Molecular Characteristics Associated with Targeting Necroptosis in Breast Cancer and their Clinical Prognostic Significance
CONCLUSION: Necroptosis genes are implicated in the pathogenesis and progression of breast cancer and are thought to impact the prognosis and response to drug treatments in individuals with BRCA. Consequently, understanding the role of these genes in breast cancer may aid in identifying more precise and efficacious therapeutic targets.PMID:37653627 | DOI:10.2174/1574892819666230831112815 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - September 1, 2023 Category: Cancer & Oncology Authors: Chang Zheng Hanbin Guo Yongpan Mo Guowen Liu Source Type: research

Identification of the Roles of Coagulation-Related Signature and its Key Factor RABIF in Hepatoma Cell Malignancy
CONCLUSION: We built a robust CRS with great potential as a prognosis and immunotherapeutic indicator. Importantly, we identified RABIF as an oncogene, promoting hepatoma cell migration and clone formation, revealing underlying pathological mechanisms, and providing novel therapeutic targets for hepatoma treatment.PMID:37644748 | DOI:10.2174/1574892819666230829151148 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - August 30, 2023 Category: Cancer & Oncology Authors: Yanying Chen Yin Li Bingyi Zhou Source Type: research