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Targeted Regulation of Osteoblasts and Osteoclasts in Osteosarcoma Patients by CSF3R Receptor Inhibition of Osteolysis Caused by Tumor Inflammation Based on Transcriptional Spectrum Analysis and Drug Library Screening
CONCLUSION: CSF3R participates in the occurrence and development of OS bone destruction by regulating the inflammatory response of osteoblasts and osteoclasts and can affect the survival prognosis of OS patients.PMID:37877147 | DOI:10.2174/0115748928259095231010055507 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - October 25, 2023 Category: Cancer & Oncology Authors: Qian Li Jinlu Shan Wei Duan Yu Chen Source Type: research

Matrix Metalloproteinase-2 (MMP-2): As an Essential Factor in Cancer Progression
Recent Pat Anticancer Drug Discov. 2023 Oct 9. doi: 10.2174/0115748928251754230922095544. Online ahead of print.ABSTRACTThe development of cancer has been a multistep process involving mutation, proliferation, survival, invasion, and metastasis. Of all the characteristics of cancer, metastasis is believed to be the hallmark as it is responsible for the highest number of cancer-related deaths. In connection with this, Matrix metalloproteinases (MMPs), that has a role in metastasis, are one of the novel therapeutic targets. MMPs belong to the family of zinc-dependent endopeptidases and are capable of degrading the components...
Source: Recent Patents on Anti-Cancer Drug Discovery - October 20, 2023 Category: Cancer & Oncology Authors: R Aishwarya Reddy M Sai Varshini R Suresh Kumar Source Type: research

The Clinical Significance and Prognostic Value of ALDH1 Expression in Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis
CONCLUSION: The expression of ALDH1 is closely associated with the clinicopathologic characteristics and prognosis of NSCLC. ALDH1 may serve as a valuable clinical assessment tool and prognostic predictor in NSCLC.PMID:37818578 | DOI:10.2174/0115748928265992230925053308 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - October 11, 2023 Category: Cancer & Oncology Authors: Dong Li Yu Cao Cheng-Wen Luo Li-Ping Zhang Ying-Bo Zou Source Type: research

Characterization of the Prognosis and Tumor Microenvironment of Cellular Senescence-related Genes through scRNA-Seq and Bulk RNA-Seq Analysis in GC
CONCLUSION: The two molecular subtypes, with their own individual OS rate, expression patterns, and immune infiltration, lay the foundation for further exploration into the GC molecular mechanism. The eight gene signatures could effectively predict the GC prognosis and can serve as reliable markers for GC patients.PMID:37807645 | DOI:10.2174/0115748928255417230924191157 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - October 9, 2023 Category: Cancer & Oncology Authors: Guoxiang Guo Zhifeng Zhou Shuping Chen Jiaqing Cheng Yang Wang Tianshu Lan Yunbin Ye Source Type: research