FDA Approves Brexpiprazole for Agitation Associated With Dementia Due to Alzheimer ’s Disease
The U.S. Food and Drug Administration (FDA) yesterdayapproved the expanded use of Rexulti (brexpiprazole) for the treatment of agitation associated with dementia due to Alzheimer ’s disease (AD).“Agitation associated with dementia due to Alzheimer’s disease is a common neuropsychiatric symptom that is reported in approximately half of all patients with Alzheimer’s dementia,” wrote Otsuka Pharmaceutical Co. Ltd. and Lundbeck LLC, makers of the medication, in apress release. The symptoms cover “a large group of behaviors occurring in patients with Alzheimer’s disease, such as pacing, gesturing, profanity, shout...
Source: Psychiatr News - May 11, 2023 Category: Psychiatry Tags: agitation Alzheimer ' s disease brexpiprazole dementia FDA Food and Drug Administration major depressive disorder Rexulti schizophrenia Source Type: research
DEA, SAMHSA Release Temporary Rule Extending Telemedicine Flexibilities
The U.S. Drug Enforcement Administration (DEA) and Substance Abuse and Mental Health Services Administration (SAMHSA)have issued a temporary rule that extends telemedicine flexibilities adopted during the COVID-19 Public Health Emergency (PHE). The temporary rule will go into effect tomorrow, May 11, when the COVID-19 PHE expires, and extends the full set of telemedicine flexibilities adopted during the COVID-19 PHE for six months (through November 11). Additional flexibilities will extend to established patients until November 11, 2024.“Access to evidence-based treatment is a pillar of the HHS Overdose Prevention Strate...
Source: Psychiatr News - May 10, 2023 Category: Psychiatry Tags: Anne Milgram APA COVID-19 PHE DEA HHS Miriam E. Delphin-Rittmon opioids public health emergency samhsa telemedicine temporary rules Source Type: research
Zuranolone Found to Quickly Reduce Major Depression Symptoms in Phase 3 Trial
Adults with major depressive disorder may experience mood improvements within days of taking zuranolone (50 mg/day), astudy inThe American Journal of Psychiatry (AJP) suggests. Zuranolone is an oral, once-daily neuroactive steroid that acts on GABA-A receptors.“[P]atients receiving zuranolone 50 mg/day demonstrated significantly greater improvements in depressive symptoms at day 15 compared with those receiving placebo,” wrote Anita H. Clayton, M.D., of the University of Virginia School of Medicine and colleagues. The study “supports the potential r ole for a 14-day therapy with oral zuranolone 50 mg/day in adults wi...
Source: Psychiatr News - May 9, 2023 Category: Psychiatry Tags: American Journal of Psychiatry depression GABA-A receptors major depressive disorder phase 3 trial rapid-acting antidepressants zuranolone Source Type: research
Early PET Scans Improve Confidence When Diagnosing Cognitive Problems
Adults who receive a positron emission tomography (PET) scan to measure brain amyloid levels shortly after seeing a doctor for cognitive problems are more likely to be confidently diagnosed within three months than those whose PET scans are delayed, suggests astudy published today inJAMA Neurology.“Amyloid deposition in the brain is one of the main hallmarks of Alzheimer disease (AD) and is considered one of the strongest risk factors of dementia,” wrote Daniele Altomare, Ph.D., of Geneva Memory Center in Switzerland and colleagues. “This evidence from [the Amyloid Imaging to Prevent Al zheimer’s Disease Diagnostic...
Source: Psychiatr News - May 8, 2023 Category: Psychiatry Tags: Alzheimer ' s disease amyloid dementia diagnosis JAMA Neurology mild cognitive impairment PET scan subjective cognitive decline Source Type: research
Psychosis Induced by Substance Use Linked to Schizophrenia
More than a quarter of people who experience substance-induced psychosis are diagnosed with schizophrenia within six years, astudy inThe American Journal of Psychiatry has found.Eline B. Rognli, Ph.D., of Oslo University Hospital and colleagues analyzed data from 3,187 patients in the Norwegian Patient Registry who were between the ages of 18 and 79 and had a diagnosis of substance-induced psychosis from 2010 to 2015. The patients had a mean age of 33.6 years, and 73.5% were men. Among the patients, 14.2% had alcohol-induced psychosis, 17.6% had cannabis-induced psychosis, 22.2% had amphetamine-induced psychosis, and 38.8%...
Source: Psychiatr News - May 5, 2023 Category: Psychiatry Tags: alcohol use American Journal of Psychiatry bipolar disorder cannabis use psychosis schizophrenia substance use Source Type: research
DEA Delays Proposed Telehealth, Buprenorphine Rules
The U.S. Drug Enforcement Administration (DEA)has delayed finalizing two proposed rules that were set to go into effect after theCOVID-19 public health emergency expires on May 11. The proposed rules, if finalized, would affect how health professionals implement telehealth services and prescribe certain controlled medications, including medications for treating attention-deficit/hyperactivity disorder and opioid use disorder (OUD). The DEA received 38,000 comments in response to the proposed rules, which wereannounced on February 24. Instead of finalizing the rules, the DEA, in concert with the U.S. Department of Health an...
Source: Psychiatr News - May 4, 2023 Category: Psychiatry Tags: Anne Milgram APA controlled substances DEA Department of Health and Human Services Drug Enforcement Administration opioid use disorder telehealth Source Type: research
Black, Hispanic Veterans More Likely Than Whites to Have AUD Diagnosis Despite Similar Drinking
Black and Hispanic veterans are more likely to be given a diagnosis of alcohol use disorder (AUD) than White veterans despite similar levels of alcohol consumption, according to areport published today inAJP in Advance. The racial discrepancy in diagnosis was evident for both men and women but was greatest for Black men who in some cases had a greater than 100% chance of having a diagnosis of AUD than White male veterans.“The absence of other factors to explain this discrepancy strongly suggests the presence of racial and ethnic biases in the diagnosis of AUD by VA practitioners,” wrote Rachel Vickers-Smith, Ph.D., of ...
Source: Psychiatr News - May 3, 2023 Category: Psychiatry Tags: alcohol use alcohol use disorder American Journal of Psychiatry AUD AUDIT-C bias black diagnosis Hispanic VA veterans white Source Type: research
Dementia, Self-Harm Found to Be Linked in Older Adults
More than 60% of people with dementia who later harm themselves tend to do so within two years of their dementia diagnosis, suggests astudy reported inAlzheimer ’s& Dementia. The study also found that older adults who harm themselves, particularly men with no prior history of such behavior, may be at greater risk of a later dementia diagnosis than those who do not.“Our results highlight the need for better mental health and behavioral supports soon after dementia diagnoses or self-harm in older people,” wrote Adrian R. Walker, Ph.D., of UNSW Sydney and colleagues.Walker and colleagues relied on linked hospital da...
Source: Psychiatr News - May 2, 2023 Category: Psychiatry Tags: Alzheimer ' s & Dementia early support older adults self-harm Source Type: research
Depression Symptoms in Youth Worsened During COVID-19 Pandemic, Meta-Analysis Finds
A meta-analysis of more than 50 longitudinal studies of children and adolescents from 12 countries has confirmed what many had feared: Symptoms of depression in youth around the world increased during the COVID-19 pandemic. Thefindings were published today inJAMA Pediatrics.“Our findings are in line with other mental health–related studies which report increases in eating disorders and emergency department visits for suicide attempts and ideation during the COVID-19 pandemic,” wrote Sheri Madigan, Ph.D., of the University of Calgary and colleagues. “The magnitu de of this [depression] increase was more than what co...
Source: Psychiatr News - May 1, 2023 Category: Psychiatry Tags: adolescents anxiety children COVID-19 depression JAMA Pediatrics meta-analysis pandemic youth mental health Source Type: research
Age at Onset of Problem Drinking May be Poor Predictor of Outcomes, Study Finds
People who begin to experience problem drinking after the age of 60 can benefit from treatment and may have better mental functioning than those who develop problem drinking earlier in life, according to astudy published this week inAlcohol: Clinical and Experimental Research.“Age of onset of problem drinking, that is, the age at which a person first experiences problems in relation to their drinking, has long been regarded as an important criterion in distinguishing between types of drinkers and in determining longer-term prognosis,” wrote Jennifer Seddon, Ph.D., M. Sc., of Oxford Brookes University and colleagues.Sed...
Source: Psychiatr News - April 28, 2023 Category: Psychiatry Tags: alcohol use disoder cognitive impairment Jennifer Seddon older problem drinkers Oxford Brooks University problem drinking treatment for alcohol use Source Type: research
Depression Associated With Hormonal Contraception Linked to Higher Risk of Postpartum Depression
This study provides evidence for the existence of a subgroup of women who are sensitive to hormonal transitions across the reproductive life span.”Vinther Larsen and colleagues used health care data from Danish national registers and included all women born in Denmark after 1978 who delivered their first child between 1996 and 2017. Participants were excluded if they had a multiple birth or stillbirth; had never used hormonal contraception; or had a depressive episode before 1996 or within 12 months prior to delivery (as this could indicate an ongoing depression while entering pregnancy).The researchers identified partic...
Source: Psychiatr News - April 27, 2023 Category: Psychiatry Tags: birth control depression hormonal birth control JAMA Psychiatry postpartum depression reproductive health women ' s health Source Type: research
Prepare Now for End of Public Health Emergency, Telepsychiatry Experts Advise
In a webinar today, APA leaders in telepsychiatry urged psychiatrists to start working with their telepsychiatry patients now to prepare for the end of COVID-19 Public Health Emergency (PHE) on May 11.Shaban Khan, M.D., director of child and adolescent telepsychiatry at NYU Langone and chair of the APA Committee on Telepsychiatry, and John Torous, M.D., director of the Digital Psychiatry Division at Beth Israel Deaconess Medical Center and chair of the APA Committee on Mental Health Information Technology, outlined what psychiatrists need to know about the status of telepsychiatry in terms of prescribing medications, licen...
Source: Psychiatr News - April 26, 2023 Category: Psychiatry Tags: CMS John Torous Medicare PHE public health emergency Shaban Khan telehealth telepsychiatry Source Type: research
Suicidal Thoughts Linked to Sleep Problems in Patients With Early Psychosis
People with early psychosis (those who have had only a single episode of psychosis) who experience persistent sleep problems are nearly 14 times as likely to report suicidal ideation as those with early psychosis who do not experience sleep problems, according to areport in Schizophrenia Bulletin.“[I]nsomnia may represent an important treatment target in psychosis,” wrote Brian J. Miller, M.D., Ph.D., of Augusta University and colleagues. Additionally, the “findings provide … evidence that formal assessment and treatment of insomnia and sleep disturbance is relevant to the clinical c are of patients with early psyc...
Source: Psychiatr News - April 25, 2023 Category: Psychiatry Tags: early psychosis ideation insomnia PANSS RAISE schizophrenia Schizophrenia Bulletin sleep problems suicidal thoughts Source Type: research
Brief Interpersonal Therapy May Reduce Prenatal Depression
Pregnant individuals experiencing elevated levels of depression may benefit more from weekly interpersonal therapy (IPT) sessions than those who receive mental health counseling and maternity social services. Thesefindings were published inJAMA Psychiatry.“Approximately 17% of pregnant individuals meet criteria for major depressive disorder (MDD) diagnosis, and up to 37% report elevated symptoms during pregnancy,” wrote Benjamin L. Hankin, Ph.D., of the University of Illinois at Urbana-Champaign and colleagues. IPT “focuses on psychoeducation a nd interpersonal skill building to decrease interpersonal conflict and in...
Source: Psychiatr News - April 24, 2023 Category: Psychiatry Tags: depression Edinburgh Postnatal Depression Scale EPDS interpersonal therapy IPT JAMA Psychiatry MomCare prenatal depression SCL-20 Symptom Checklist Source Type: research
Nearly 6 in 10 Patients With Bipolar Disorder Do Not Fill All of Their Prescriptions
A majority of patients who are prescribed medications for bipolar disorder do not fill their prescriptions as often as they receive them, astudy in theJournal of Affective Disorders has found.Jonne Lintunen, M.D., Ph.D., of Niuvanniemi Hospital in Kuopio, Finland, and colleagues studied data from Finnish health and prescription registries for 33,131 adults who have bipolar disorder. The patients were diagnosed with bipolar disorder between 1987 and 2018, and the researchers followed dispensing rates of electronic prescriptions from 2015 to 2018. Among all patients, 61.8% had at least one prescription for a mood stabilizer,...
Source: Psychiatr News - April 21, 2023 Category: Psychiatry Tags: antipsychotics bipolar disorder clozapine Journal of Affective Disorders lithium mood stabilizers nonadherence prescriptions Source Type: research
