Cardiovascular calcifications in dialysis patients
Nephrol Ther. 2023 Nov 2;19(6):532-541. doi: 10.1684/ndt.2023.45.ABSTRACTPatients with advanced chronic kidney disease and those already on dialysis have an increased prevalence of cardiovascular calcifications. They are the cause of severe complications and are associated with a reduced life expectancy in these patients. Recommendations and imaging scores have been developed to detect and assess their importance, to guide and improve the management of cardiovascular risk. However, despite these recommendations, current practice teaches us that they are only partially applied. The prevention and treatment of cardiovascular...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Pablo Ure ña Torres Charles Chazot Source Type: research
Immune modulation with extracorporeal photopheresis in renal transplantation: proof of concept clinical outcomes and perspective
Nephrol Ther. 2023 Nov 2;19(6):521-531. doi: 10.1684/ndt.2023.46.ABSTRACTFor 30 years, photopheresis is used to treat graft versus host disease and heart or lung allograft rejection. In this review, we discuss the place of photopheresis in kidney transplantation both in prevention or treatment of rejection. Mechanisms of action in kidney transplantation are mainly based on results observed in graft versus host disease and in heart or lung transplantation. Photopheresis may induce innate and adaptive immunity changes with restauration of a favourable Th1/Th2 immune balance, an expansion of LT /LB reg subsets, and a local en...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Thomas Cr épin Arnaud Lionet Jean-Fran çois Augusto Marc Hazzan Cyril Garrouste Anne-Elisabeth Heng Didier Ducloux Source Type: research
Heart disease in hemodialysis: physiopathology and therapeutic breakthroughs
Nephrol Ther. 2023 Nov 2;19(6):542-551. doi: 10.1684/ndt.2023.47.ABSTRACTEspecially exposed to frequent cardiovascular events and its related mortality, some cardiovascular therapies of the hemodialyzed population as well as coronary investigations remain controversial. We have collected data and discussed recent trials and guidelines dedicated to this patient subset.PMID:37915198 | DOI:10.1684/ndt.2023.47 (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Lucile Mercadal Jean-Jacques Boffa Jean-Philippe Collet Source Type: research
Impact of physical activity in non-dialysis CKD patients followed in a multidisciplinary care network on the progression of chronic renal failure – PHYSALYS study
Nephrol Ther. 2023 Nov 2;19(6):507-519. doi: 10.1684/ndt.2023.48.ABSTRACTPhysical activity (PA), has a proven effect on overall health. The study assessed the difference in glomerular filtration rate (GFR) over one year in non-dialysis renal failure patients between those who practiced exercise (P) and those who did not (NP). Patients were categorised as P or not P using the Global Physical Activity Questionnaire (GPAQ2), completed by telephone, at inclusion and at 12 months. Among the 259 patients included, 195 (75.3%) practiced a PA and 64 (24.7%) did not practiced. There was no significant difference in the slope of GFR...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: No émie Rossello Évelyne Decullier Christelle Marolho Anne Jolivot Maurice Laville Source Type: research
COVID-19 early curative treatments in kidney transplant recipients: is it really reasonable at the Omicron era?
CONCLUSIONS: There was no difference in outcome according to early therapeutic management: n/r, sotrovimab or no specific treatment. Our study both underlines a decreased severity of Omicron COVID-19 in KTRs (probably related to vaccinal immunity and decreased virulence of Omicron) and a potential severe adverse effects with n/r.PMID:37915200 | DOI:10.1684/ndt.2023.44 (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Yanis Tamzali Alexia Lundy Alexandre Bleibtreu Maud Cazenave Inna Mohammadou Nadia Arzouk Pierre Galichon St éphane Marot Helga Junot Beno ît Barrou Val érie Pourcher J érôme Tourret Source Type: research
Pruritus associated with chronic kidney disease in hemodialysis patients: a survey in French nephrologists
CONCLUSION: These results show that according to the opinion of nephrologists, the pruritus prevalence is low in dialysis patients. This is inconsistent with studies based on systematic patient interviews, thus suggesting that pruritus is a symptom overlooked by nephrologists. In the context of the arrival of a new drug for pruritus, patients should be more questioned about this symptom in order to propose this treatment.PMID:37915193 | DOI:10.1684/ndt.2023.31 (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Maxime Touzot Pierre Bataille Guy Rostoker Philippe Chauveau Antoine Lanot Laurent Misery Source Type: research
Atypical hemolytic and uremic syndrome in Algeria: diagnostic difficulties and therapeutic constraints
Nephrol Ther. 2023 Nov 2;19(6):483-490. doi: 10.1684/ndt.2023.37.ABSTRACTAtypical Hemolytic Uremic Syndrome (aHUS) is a systemic disease due to dysregulation of the alternate complement pathway, mortality is estimated at 10% and more than 50% of patients progress to end-stage renal disease. The aim of this study was to summarize the clinical data and biological results as well as the evolution and management of patients with aHUS seen over a period of four years in one specialized department in Algeria. Our study was observational and longitudinal. The inclusion criteria were: the clinical-biological triad of aHUS and age ...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Souad Chelghoum Farid Haddoum Kamel Djenouhat Mohamed-Taher Hamlaoui Nawel Adjlane Mourad Boukheloua Source Type: research
Functional vesico-sphincteric disorders in children: clinical, urodynamic and evolutionary profile
CONCLUSION: Given the seriousness of vesico-sphincteric disorders in children and the late discovery in the majority of cases at the complication stage, targeted primary prevention must be carried out based on continuous training of primary care physicians to minimize the appearance of complications involving the functional and vital prognosis of these children.PMID:37915195 | DOI:10.1684/ndt.2023.38 (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Maryem Ferjani Yousra Hammi Taha Sayari Rym Baati Naija Ouns Tahar Gargah Source Type: research
Cardiovascular calcifications in dialysis patients
Nephrol Ther. 2023 Nov 2;19(6):532-541. doi: 10.1684/ndt.2023.45.ABSTRACTPatients with advanced chronic kidney disease and those already on dialysis have an increased prevalence of cardiovascular calcifications. They are the cause of severe complications and are associated with a reduced life expectancy in these patients. Recommendations and imaging scores have been developed to detect and assess their importance, to guide and improve the management of cardiovascular risk. However, despite these recommendations, current practice teaches us that they are only partially applied. The prevention and treatment of cardiovascular...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Pablo Ure ña Torres Charles Chazot Source Type: research
Immune modulation with extracorporeal photopheresis in renal transplantation: proof of concept clinical outcomes and perspective
Nephrol Ther. 2023 Nov 2;19(6):521-531. doi: 10.1684/ndt.2023.46.ABSTRACTFor 30 years, photopheresis is used to treat graft versus host disease and heart or lung allograft rejection. In this review, we discuss the place of photopheresis in kidney transplantation both in prevention or treatment of rejection. Mechanisms of action in kidney transplantation are mainly based on results observed in graft versus host disease and in heart or lung transplantation. Photopheresis may induce innate and adaptive immunity changes with restauration of a favourable Th1/Th2 immune balance, an expansion of LT /LB reg subsets, and a local en...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Thomas Cr épin Arnaud Lionet Jean-Fran çois Augusto Marc Hazzan Cyril Garrouste Anne-Elisabeth Heng Didier Ducloux Source Type: research
Heart disease in hemodialysis: physiopathology and therapeutic breakthroughs
Nephrol Ther. 2023 Nov 2;19(6):542-551. doi: 10.1684/ndt.2023.47.ABSTRACTEspecially exposed to frequent cardiovascular events and its related mortality, some cardiovascular therapies of the hemodialyzed population as well as coronary investigations remain controversial. We have collected data and discussed recent trials and guidelines dedicated to this patient subset.PMID:37915198 | DOI:10.1684/ndt.2023.47 (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Lucile Mercadal Jean-Jacques Boffa Jean-Philippe Collet Source Type: research
Impact of physical activity in non-dialysis CKD patients followed in a multidisciplinary care network on the progression of chronic renal failure – PHYSALYS study
Nephrol Ther. 2023 Nov 2;19(6):507-519. doi: 10.1684/ndt.2023.48.ABSTRACTPhysical activity (PA), has a proven effect on overall health. The study assessed the difference in glomerular filtration rate (GFR) over one year in non-dialysis renal failure patients between those who practiced exercise (P) and those who did not (NP). Patients were categorised as P or not P using the Global Physical Activity Questionnaire (GPAQ2), completed by telephone, at inclusion and at 12 months. Among the 259 patients included, 195 (75.3%) practiced a PA and 64 (24.7%) did not practiced. There was no significant difference in the slope of GFR...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: No émie Rossello Évelyne Decullier Christelle Marolho Anne Jolivot Maurice Laville Source Type: research
COVID-19 early curative treatments in kidney transplant recipients: is it really reasonable at the Omicron era?
CONCLUSIONS: There was no difference in outcome according to early therapeutic management: n/r, sotrovimab or no specific treatment. Our study both underlines a decreased severity of Omicron COVID-19 in KTRs (probably related to vaccinal immunity and decreased virulence of Omicron) and a potential severe adverse effects with n/r.PMID:37915200 | DOI:10.1684/ndt.2023.44 (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Yanis Tamzali Alexia Lundy Alexandre Bleibtreu Maud Cazenave Inna Mohammadou Nadia Arzouk Pierre Galichon St éphane Marot Helga Junot Beno ît Barrou Val érie Pourcher J érôme Tourret Source Type: research
Pruritus associated with chronic kidney disease in hemodialysis patients: a survey in French nephrologists
CONCLUSION: These results show that according to the opinion of nephrologists, the pruritus prevalence is low in dialysis patients. This is inconsistent with studies based on systematic patient interviews, thus suggesting that pruritus is a symptom overlooked by nephrologists. In the context of the arrival of a new drug for pruritus, patients should be more questioned about this symptom in order to propose this treatment.PMID:37915193 | DOI:10.1684/ndt.2023.31 (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Maxime Touzot Pierre Bataille Guy Rostoker Philippe Chauveau Antoine Lanot Laurent Misery Source Type: research
Atypical hemolytic and uremic syndrome in Algeria: diagnostic difficulties and therapeutic constraints
Nephrol Ther. 2023 Nov 2;19(6):483-490. doi: 10.1684/ndt.2023.37.ABSTRACTAtypical Hemolytic Uremic Syndrome (aHUS) is a systemic disease due to dysregulation of the alternate complement pathway, mortality is estimated at 10% and more than 50% of patients progress to end-stage renal disease. The aim of this study was to summarize the clinical data and biological results as well as the evolution and management of patients with aHUS seen over a period of four years in one specialized department in Algeria. Our study was observational and longitudinal. The inclusion criteria were: the clinical-biological triad of aHUS and age ...
Source: Nephrologie and Therapeutique - November 2, 2023 Category: Urology & Nephrology Authors: Souad Chelghoum Farid Haddoum Kamel Djenouhat Mohamed-Taher Hamlaoui Nawel Adjlane Mourad Boukheloua Source Type: research
