Favorable prognostic significance of membranous β-catenin expression and negative prognostic significance of cytoplasmic β-catenin expression in pancreatic cancer
Neoplasma. 2023 Dec;70(6):796-803. doi: 10.4149/neo_2023_230721N380.ABSTRACTThe aim of this study was to investigate the prognostic significance of membranous β-catenin and cytoplasmic β-catenin expression in pancreatic cancer patients (pts). One hundred pts with histologically verified exocrine pancreatic ductal adenocarcinoma were retrospectively studied. The membranous β-catenin, cytoplasmic β-catenin, and cell nucleus β-catenin expression were immunohistochemically evaluated. The expression of membranous β-catenin was <5% in none of the pts, 5-25% in one patient, 26-50% in 2 pts, 51-75% in 14 pts, and >75% ...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Blanka Rosova Jan Proks Alzbeta Filipova Dimitar Hadzi Nikolov Renata Chloupkova Igor Richter Arpad Szabo Aneta Rozsypalova Radoslav Matej Bohuslav Melichar Tomas Buchler Josef Dvorak Source Type: research
Treatment for SMARCB1 (INI-1) deficient sinonasal tumor: a single-institution study
Neoplasma. 2023 Dec;70(6):804-810. doi: 10.4149/neo_2023_230910N480.ABSTRACTCurrently, less than 200 cases of SMARCB1-deficient sinus cancer (SDSC) have been documented. Little information is available about the best treatment options or prognosis for SDSC. From September 2016 to November 2022, the medical records of 22 people with SDSC were evaluated retrospectively. Patient demographics, staging, pathology findings, treatment details, recurrence, metastasis, and survival outcomes were all investigated by the researchers. The 1-, 2-, and 3-year overall survival (OS) rates for the entire cohort were 89.8%, 84.2%, and 45.1%...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Tian Wang Jie Wang Tianci Tang Li Wang Yi Li Xinmao Song Source Type: research
The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix
In conclusion, for surgically treated SCNCC, adjuvant chemotherapy showed a positive influence on DFS while neoadjuvant chemotherapy harmed DFS. OS was unaffected by either treatment choice.PMID:38215035 | DOI:10.4149/neo_2023_230802N404 (Source: Neoplasma)
Source: Neoplasma - January 12, 2024 Category: Cancer & Oncology Authors: Deying Zhao Shaoxing Sun Zhiyong Yang Ping Wang Hui Qiu Source Type: research
USP36 plays an oncogenic role in colorectal cancer cells
In this study, we investigated the potential role of ubiquitin-specific protease 36 (USP36) in CRC. Our bioinformatic analysis revealed a significant upregulation of USP36 expression in CRC, and high USP36 levels were associated with poor prognosis in CRC patients. Furthermore, we observed an increase in USP36 expression in CRC cell lines. Knockdown of USP36 resulted in reduced viability, cell cycle arrest, increased apoptosis, and impaired migration and invasion in CRC cells. Additionally, the colony formation and sphere formation ability, as well as the expression of stem cell markers and pluripotent transcription factor...
Source: Neoplasma - January 12, 2024 Category: Cancer & Oncology Authors: Lixiong Luo Yijiang Li Rongjie Huang Ling Li Chuncai Wu Qunzhang Zeng Source Type: research
RASSF1A promotes radiosensitivity in nasopharyngeal carcinoma by promoting FoxO3a and inhibiting the Nrf2/TXNRD1 signaling pathway
Neoplasma. 2023 Oct;70(5):633-644. doi: 10.4149/neo_2023_221122N1124.ABSTRACTRadiotherapy is widely used as the first-line treatment for nasopharyngeal carcinoma (NPC). However, the resistance of some patients to treatment lowers its clinical effectiveness. Compared to typical epithelial cells, NPC markedly lowers the Ras-association domain family 1A (RASSF1A) protein expression. RASSF1A overexpression sensitizes NPC cells to radiotherapy. Mechanistically, RASSF1A promotes the expression of Forkhead box O3a (FoxO3a) in the nucleus and inhibits the Nuclear factor E2-related factor 2 (Nrf2) signaling pathway via binding to t...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yishimei Si Linghan Meng Bingwen Zhang Yuanqing Wu Qianming Du Jinjing Xu Jianwei Qi Source Type: research
Desmoplasia in non-small cell lung carcinomas is associated with low programmed death-ligand 1 expression and the absence of tumor-infiltrating lymphocytes
In conclusion, to our knowledge, this is the first study that points to major differences in terms of immunological attributes between desmoplastic and non-desmoplastic areas in NSCLC. The desmoplastic component, therefore, may represent an immunologically distinct tumor area in which PD-L1 immunohistochemistry and CD8+ T cell count should be evaluated separately.PMID:38053375 | DOI:10.4149/neo_2023_221213N1178 (Source: Neoplasma)
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Vladim ír Tancoš Luk áš Plank Anna Farka šová Marian Grend ár Alena Mazur áková Zdenko Hu ťka Zuzana Kviatkovsk á Source Type: research
TRIM11 regulated by m6A modification promotes the progression of cervical cancer by PHLPP1 ubiquitination
Neoplasma. 2023 Oct;70(5):659-669. doi: 10.4149/neo_2023_230104N7.ABSTRACTCervical cancer (CC) is a common cancer in women and a serious threat to women's lives. TRIM11 has been confirmed as a carcinogen in multiple cancers. Here, we will excavate the detailed mechanism of TRIM11 in CC. CC cell lines and nude mice were experimental subjects in this study. The abundance of genes and proteins was detected using qRT-PCR, western blot, and IHC. Cell proliferation, migration, and invasion were determined by CCK-8 assay, wound healing assay, and Transwell, respectively. The interactions among METTL14, TRIM11, and PHLPP1 were con...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Pu Zhang Yi Tang Jing Zhao Jing Yang Yan Chen Yingping Gong Shengjun Meng Chuqiang Shu Source Type: research
Exploring the expression of SNHG1 and its effect on the PI3K-AKT axis in nasopharyngeal cancer
This study first analyzed the diagnostic performance and related signaling pathways of SNHG1 in NPC through bioinformatics. The expression of SNHG1 was verified by RT-qPCR, and the expression of the signaling pathway was detected using immunohistochemistry. Bioinformatics analysis results showed that SNHG1 was significantly overexpressed in head and neck squamous cell carcinoma (HNSC) and NPC tissues. RT-qPCR detection confirmed the significant overexpression of SNHG1 in NPC tissues. Enrichment analysis showed that SNHG1 may act on NPC through the PI3K-AKT signaling pathway. Immunohistochemistry experiment revealed PI3K-AK...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yong Yang Yan-Ping Yang Mei-Ling Yi Fang-Ting Huang Xia Zhu Guang-Wu Huang Source Type: research
MCM2 promotes the stemness of endometrial cancer cells via the Akt/ β-catenin pathway
In this study, we aim to determine the biological function of MCM2 in EC cells and identify the potential underlying mechanisms. MCM2 expression and prognostic significance were analyzed in TCGA-UCEC datasets. Combining bioinformatics analyses and experiments, stemness-related molecules and phenotypes were examined to evaluate the impact of MCM2 on stemness in EC cells. The major findings of these analyses are as follows: 1) MCM2 is expressed at higher levels in EC tissues than in normal endometrial tissues. High expression of MCM2 is related to the characteristics of poorly differentiated EC. High MCM2 expression is corre...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yuening Chu Xiaoting Jin Xiaoqing Guo Source Type: research
RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13
In this study, the function and mechanism of RNASEH1-AS1 in CRC were investigated. RT-qPCR and western blot detected the expression of targeted genes in tissues and cells. CCK-8, clone formation, wound healing assay, and Transwell were applied to evaluate CRC cell malignant behaviors. ChIP, RIP, and RNA pull-down validated interactions among RNASEH1-AS1, H3K27ac, CBP, BUD13, and ANXA2. Nucleoplasmic separation and FISH assay determined the location of RNASEH1-AS1 in CRC cells. IHC assay was used to detect Ki-67 expression in tumor tissues from mice. RNASEH1-AS1 was highly expressed in CRC tumor tissues and cells. RNASEH1-A...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Shengwei Zhuang Weihong Lu Lianjun Shen Zhekun Huang Xiuping Zhang Yong Zhang Source Type: research
A pan-cancer analysis of RGR opsin expression and its downregulation associated with poor prognosis in glioma
Neoplasma. 2023 Oct;70(5):683-696. doi: 10.4149/neo_2023_230617N317.ABSTRACTRetinal G protein-coupled receptor (RGR) serves a retinal photoisomerase function to mediate retinoid metabolism and visual chromophore regeneration in the human eyes. Retinoids display critical functions in cell proliferation, differentiation, and apoptosis. Abnormal retinoid metabolism may contribute to tumor development. However, in human tumor tissues, the expression of RGR remains uncharacterized. Herein, we performed the analysis of RGR expression in 620 samples from 24 types of tumors by immunohistochemistry (IHC) and 33 cancer types from th...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Jianglong Feng Wei Zhang Wen Zeng Yu Wang Yangguang Gu Yinghua Lan Wenxiu Yang Hongguang Lu Source Type: research
Brain metastasis from esophageal squamous cell carcinoma: a clinical review of 30 cases
This study aimed to retrospectively evaluate the treatment strategies and possible prognostic factors in patients with brain metastases (BMs) from esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed 30 patients with BMs from ESCC who were treated at our center between November 2011 and January 2022. Clinicopathological characteristics and clinical outcomes were analyzed. The median follow-up time was 2 (range, 0.5-33) months. The median survival time after diagnosis of BMs was 2 months. The 1-year overall survival (OS) rate was 13.6%. The OS was better in patients with intracranial benefit. Multivariate ...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yu Yang Yang Yang Xiuwei Wu Nianfei Wang Mingjun Zhang Source Type: research
GPX3 is a key cholesterol-related gene associated with prognosis and tumor-infiltrating T cells in colorectal cancer
In conclusion, GPX3 is a potential target for cholesterol regulation of T cell immunity in CRC.PMID:38053382 | DOI:10.4149/neo_2023_230704N348 (Source: Neoplasma)
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Jiming Chen Yinhang Wu Qing Zhou Yifei Song Jing Zhuang Kongjie Lu Xi Yang Source Type: research
ΔNp63 is regulated by insulin/IGF-1 signaling in normal basal/progenitor mammary cells and in luminal-type breast cancer cells
Neoplasma. 2023 Oct;70(5):621-632. doi: 10.4149/neo_2023_230719N376.ABSTRACTBreast cancers are a heterogeneous group of tumors classified according to their histological growth patterns and receptor expression characteristics. Intratumor heterogeneity also exists, with subpopulations of cells with different phenotypes found in individual cancers, including cells with stem or progenitor cell properties. At least two types of breast cancer stem cells (CSCs) exist, the epithelial and the basal/mesenchymal subtypes, although how these phenotypes are controlled is unknown. ΔNp63 is a basal cell marker and regulator of stem/pro...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Michaela Stenckova Yajing Liu Marta Nekulova Jitka Holcakova Zuzana Pokorna Rudolf Nenutil Alastair M Thompson Borivoj Vojtesek Philip John Coates Source Type: research
RASSF1A promotes radiosensitivity in nasopharyngeal carcinoma by promoting FoxO3a and inhibiting the Nrf2/TXNRD1 signaling pathway
Neoplasma. 2023 Oct;70(5):633-644. doi: 10.4149/neo_2023_221122N1124.ABSTRACTRadiotherapy is widely used as the first-line treatment for nasopharyngeal carcinoma (NPC). However, the resistance of some patients to treatment lowers its clinical effectiveness. Compared to typical epithelial cells, NPC markedly lowers the Ras-association domain family 1A (RASSF1A) protein expression. RASSF1A overexpression sensitizes NPC cells to radiotherapy. Mechanistically, RASSF1A promotes the expression of Forkhead box O3a (FoxO3a) in the nucleus and inhibits the Nuclear factor E2-related factor 2 (Nrf2) signaling pathway via binding to t...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yishimei Si Linghan Meng Bingwen Zhang Yuanqing Wu Qianming Du Jinjing Xu Jianwei Qi Source Type: research
