The role of polyethylenimine-functionalized gold nanoclusters carrying plasmid CMTM5 in impeding the malignant progression of prostate cancer cells by promoting EGFR endocytosis
In conclusion, the PEI-AuNCs nano-delivery system exhibits good biocompatibility and efficaciously conveys pCMTM5 to PCa cells. Crucially, pCMTM5 does not directly interact with EGFR, and CMTM5 governs the malignant progression of PC3 cells by promoting EGFR endocytosis.PMID:38295104 | DOI:10.4149/neo_2024_231018N544 (Source: Neoplasma)
Source: Neoplasma - January 31, 2024 Category: Cancer & Oncology Authors: Linjin Li Chengpeng Li Feilong Miao Wu Chen Xianghui Kong Ruxian Ye Rui Feng Source Type: research
CCDC86 promotes the aggressive behavior of nasopharyngeal carcinoma by positively regulating EGFR and activating the PI3K/Akt signaling
Neoplasma. 2023 Dec;70(6):761-776. doi: 10.4149/neo_2023_221021N1039.ABSTRACTNasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck. A number of studies have confirmed that coiled-coil domain-containing protein 86 (CCDC86) plays an important role in the pathogenesis of lymphoma but the role of CCDC86 in NPC has not yet been reported. Here, in vivo and in vitro experiments were conducted to explore whether CCDC86 plays a role in the pathogenesis of NPC and to identify the specific mechanism. We found that CCDC86 was highly expressed in NPC tissues and cells, and the expression level of CCDC86 was co...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Zhi Wang Tao Zhou Xubo Chen Xinhua Zhu Bing Liao Jianguo Liu Siqi Li Ting Tan Yuehui Liu Source Type: research
CHAC1 promotes cell ferroptosis and enhances radiation sensitivity in thyroid carcinoma
Neoplasma. 2023 Dec;70(6):777-786. doi: 10.4149/neo_2023_230103N4.ABSTRACTChaC glutathione-specific γ-glutamylcyclotransferase 1 (CHAC1) is involved in intracellular glutathione depletion, ferroptosis, and tumorigenesis. The functional role of CHAC1 expression in thyroid carcinoma has not yet been established. The present study aimed to investigate the impact and mechanisms of CHAC1 on ferroptosis and radiation sensitivity in thyroid carcinoma. CHAC1 expression was examined in tumor tissue specimens and microarrays and thyroid carcinoma cell lines. CHAC1 was silenced or overexpressed by lentivirus transfection in thyroid ...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Xinlin Yang Miao Zhang Wei Xia Zhongchao Mai Ying Ye Bin Zhao Yanan Song Source Type: research
Sintilimab, bevacizumab biosimilar, and HAIC for unresectable hepatocellular carcinoma conversion therapy: a prospective, single-arm phase II trial
Neoplasma. 2023 Dec;70(6):811-818. doi: 10.4149/neo_2023_230806N413.ABSTRACTWe assessed the efficacy and safety of sintilimab [an anti-programmed death (PD-1)] plus bevacizumab biosimilar (IBI305), and hepatic arterial infusion chemotherapy (HAIC) in patients with unresectable hepatocellular carcinoma (HCC). The patients received sintilimab (200 mg) plus IBI305 (7.5 mg/kg) and HAIC (FOLFOX for 23 h) and were treated every 3 weeks. The primary endpoint was the objective response rate (ORR) assessed by an independent review committee (IRC) per mRECIST v1.1. Twenty-nine patients were enrolled in our clinical trial (1 patient ...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Dongming Liu Han Mu Changfu Liu Weihao Zhang Yunlong Cui Qiang Wu Xiaolin Zhu Feng Fang Wei Zhang Wenge Xing Qiang Li Tianqiang Song Wei Lu Huikai Li Source Type: research
Innervation density and types of nerves in prostate cancer
Neoplasma. 2023 Dec;70(6):787-795. doi: 10.4149/neo_2023_231116N593.ABSTRACTInnervation of cancerous tissue represents an important pathway enabling the nervous system to influence the processes associated with the initiation, progression, and metastasis of a neoplastic process. In the context of prostate cancer, several papers report the presence of innervation and its modulating effect on the cancer prognosis. However, most of the data are experimental, with limited information on human prostate cancer innervation. Morphometric analysis of archival prostate specimen immunohistochemistry with neural markers PGP9.5 and S10...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Filip Blasko Lucia Krivosikova Pavel Babal Jan Breza Branislav Trebaticky Roman Kuruc Boris Mravec Pavol Janega Source Type: research
Favorable prognostic significance of membranous β-catenin expression and negative prognostic significance of cytoplasmic β-catenin expression in pancreatic cancer
Neoplasma. 2023 Dec;70(6):796-803. doi: 10.4149/neo_2023_230721N380.ABSTRACTThe aim of this study was to investigate the prognostic significance of membranous β-catenin and cytoplasmic β-catenin expression in pancreatic cancer patients (pts). One hundred pts with histologically verified exocrine pancreatic ductal adenocarcinoma were retrospectively studied. The membranous β-catenin, cytoplasmic β-catenin, and cell nucleus β-catenin expression were immunohistochemically evaluated. The expression of membranous β-catenin was <5% in none of the pts, 5-25% in one patient, 26-50% in 2 pts, 51-75% in 14 pts, and >75% ...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Blanka Rosova Jan Proks Alzbeta Filipova Dimitar Hadzi Nikolov Renata Chloupkova Igor Richter Arpad Szabo Aneta Rozsypalova Radoslav Matej Bohuslav Melichar Tomas Buchler Josef Dvorak Source Type: research
Treatment for SMARCB1 (INI-1) deficient sinonasal tumor: a single-institution study
Neoplasma. 2023 Dec;70(6):804-810. doi: 10.4149/neo_2023_230910N480.ABSTRACTCurrently, less than 200 cases of SMARCB1-deficient sinus cancer (SDSC) have been documented. Little information is available about the best treatment options or prognosis for SDSC. From September 2016 to November 2022, the medical records of 22 people with SDSC were evaluated retrospectively. Patient demographics, staging, pathology findings, treatment details, recurrence, metastasis, and survival outcomes were all investigated by the researchers. The 1-, 2-, and 3-year overall survival (OS) rates for the entire cohort were 89.8%, 84.2%, and 45.1%...
Source: Neoplasma - January 22, 2024 Category: Cancer & Oncology Authors: Tian Wang Jie Wang Tianci Tang Li Wang Yi Li Xinmao Song Source Type: research
The impact of neo/adjuvant treatment choices on prognosis for surgically treated small-cell neuroendocrine carcinoma of the cervix
In conclusion, for surgically treated SCNCC, adjuvant chemotherapy showed a positive influence on DFS while neoadjuvant chemotherapy harmed DFS. OS was unaffected by either treatment choice.PMID:38215035 | DOI:10.4149/neo_2023_230802N404 (Source: Neoplasma)
Source: Neoplasma - January 12, 2024 Category: Cancer & Oncology Authors: Deying Zhao Shaoxing Sun Zhiyong Yang Ping Wang Hui Qiu Source Type: research
USP36 plays an oncogenic role in colorectal cancer cells
In this study, we investigated the potential role of ubiquitin-specific protease 36 (USP36) in CRC. Our bioinformatic analysis revealed a significant upregulation of USP36 expression in CRC, and high USP36 levels were associated with poor prognosis in CRC patients. Furthermore, we observed an increase in USP36 expression in CRC cell lines. Knockdown of USP36 resulted in reduced viability, cell cycle arrest, increased apoptosis, and impaired migration and invasion in CRC cells. Additionally, the colony formation and sphere formation ability, as well as the expression of stem cell markers and pluripotent transcription factor...
Source: Neoplasma - January 12, 2024 Category: Cancer & Oncology Authors: Lixiong Luo Yijiang Li Rongjie Huang Ling Li Chuncai Wu Qunzhang Zeng Source Type: research
RASSF1A promotes radiosensitivity in nasopharyngeal carcinoma by promoting FoxO3a and inhibiting the Nrf2/TXNRD1 signaling pathway
Neoplasma. 2023 Oct;70(5):633-644. doi: 10.4149/neo_2023_221122N1124.ABSTRACTRadiotherapy is widely used as the first-line treatment for nasopharyngeal carcinoma (NPC). However, the resistance of some patients to treatment lowers its clinical effectiveness. Compared to typical epithelial cells, NPC markedly lowers the Ras-association domain family 1A (RASSF1A) protein expression. RASSF1A overexpression sensitizes NPC cells to radiotherapy. Mechanistically, RASSF1A promotes the expression of Forkhead box O3a (FoxO3a) in the nucleus and inhibits the Nuclear factor E2-related factor 2 (Nrf2) signaling pathway via binding to t...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yishimei Si Linghan Meng Bingwen Zhang Yuanqing Wu Qianming Du Jinjing Xu Jianwei Qi Source Type: research
Desmoplasia in non-small cell lung carcinomas is associated with low programmed death-ligand 1 expression and the absence of tumor-infiltrating lymphocytes
In conclusion, to our knowledge, this is the first study that points to major differences in terms of immunological attributes between desmoplastic and non-desmoplastic areas in NSCLC. The desmoplastic component, therefore, may represent an immunologically distinct tumor area in which PD-L1 immunohistochemistry and CD8+ T cell count should be evaluated separately.PMID:38053375 | DOI:10.4149/neo_2023_221213N1178 (Source: Neoplasma)
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Vladim ír Tancoš Luk áš Plank Anna Farka šová Marian Grend ár Alena Mazur áková Zdenko Hu ťka Zuzana Kviatkovsk á Source Type: research
TRIM11 regulated by m6A modification promotes the progression of cervical cancer by PHLPP1 ubiquitination
Neoplasma. 2023 Oct;70(5):659-669. doi: 10.4149/neo_2023_230104N7.ABSTRACTCervical cancer (CC) is a common cancer in women and a serious threat to women's lives. TRIM11 has been confirmed as a carcinogen in multiple cancers. Here, we will excavate the detailed mechanism of TRIM11 in CC. CC cell lines and nude mice were experimental subjects in this study. The abundance of genes and proteins was detected using qRT-PCR, western blot, and IHC. Cell proliferation, migration, and invasion were determined by CCK-8 assay, wound healing assay, and Transwell, respectively. The interactions among METTL14, TRIM11, and PHLPP1 were con...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Pu Zhang Yi Tang Jing Zhao Jing Yang Yan Chen Yingping Gong Shengjun Meng Chuqiang Shu Source Type: research
Exploring the expression of SNHG1 and its effect on the PI3K-AKT axis in nasopharyngeal cancer
This study first analyzed the diagnostic performance and related signaling pathways of SNHG1 in NPC through bioinformatics. The expression of SNHG1 was verified by RT-qPCR, and the expression of the signaling pathway was detected using immunohistochemistry. Bioinformatics analysis results showed that SNHG1 was significantly overexpressed in head and neck squamous cell carcinoma (HNSC) and NPC tissues. RT-qPCR detection confirmed the significant overexpression of SNHG1 in NPC tissues. Enrichment analysis showed that SNHG1 may act on NPC through the PI3K-AKT signaling pathway. Immunohistochemistry experiment revealed PI3K-AK...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yong Yang Yan-Ping Yang Mei-Ling Yi Fang-Ting Huang Xia Zhu Guang-Wu Huang Source Type: research
MCM2 promotes the stemness of endometrial cancer cells via the Akt/ β-catenin pathway
In this study, we aim to determine the biological function of MCM2 in EC cells and identify the potential underlying mechanisms. MCM2 expression and prognostic significance were analyzed in TCGA-UCEC datasets. Combining bioinformatics analyses and experiments, stemness-related molecules and phenotypes were examined to evaluate the impact of MCM2 on stemness in EC cells. The major findings of these analyses are as follows: 1) MCM2 is expressed at higher levels in EC tissues than in normal endometrial tissues. High expression of MCM2 is related to the characteristics of poorly differentiated EC. High MCM2 expression is corre...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Yuening Chu Xiaoting Jin Xiaoqing Guo Source Type: research
RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13
In this study, the function and mechanism of RNASEH1-AS1 in CRC were investigated. RT-qPCR and western blot detected the expression of targeted genes in tissues and cells. CCK-8, clone formation, wound healing assay, and Transwell were applied to evaluate CRC cell malignant behaviors. ChIP, RIP, and RNA pull-down validated interactions among RNASEH1-AS1, H3K27ac, CBP, BUD13, and ANXA2. Nucleoplasmic separation and FISH assay determined the location of RNASEH1-AS1 in CRC cells. IHC assay was used to detect Ki-67 expression in tumor tissues from mice. RNASEH1-AS1 was highly expressed in CRC tumor tissues and cells. RNASEH1-A...
Source: Neoplasma - December 6, 2023 Category: Cancer & Oncology Authors: Shengwei Zhuang Weihong Lu Lianjun Shen Zhekun Huang Xiuping Zhang Yong Zhang Source Type: research
