Downregulation of SIRT6 and NMNAT2 is associated with proliferative diabetic retinopathy
CONCLUSIONS: The downregulated expression of SIRT6 and NMNAT2 in PDR patients reveals a potential pathogenic association; more extended studies could verify them as potential therapeutic targets.PMID:38222451 | PMC:PMC10784219 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Hui Chen Xiongze Zhang Nanying Liao Yuying Ji Lan Mi Yuhong Gan Yongyue Su Feng Wen Source Type: research
The Association between Cholesterol Levels and Severity of Normal Tension Glaucoma
CONCLUSIONS: A significantly lower serum HDL concentration was found in the NTG patients, which was negatively associated with disease severity. The findings warrant further study to elucidate the role of these phenomena in the pathogenesis of glaucoma.PMID:38222452 | PMC:PMC10784211 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Yu-Chieh Wu Chien-Chih Chou Chun-Yuan Wang Source Type: research
Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children
CONCLUSIONS: Rs2071623 within VIPR2 could interact with outdoor time in Han Chinese children. More outdoor exposure could enhance the protective effect of the T allele on axial elongation.PMID:38222453 | PMC:PMC10784227 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Xi He Caixia Lin Fengchuan Zhang Sanguo Zhang Mengtian Kang Shifei Wei He Li Ningli Wang Shi-Ming Li Source Type: research
Light damage induces inflammatory factors in mouse retina and vitreous humor
CONCLUSIONS: Given that the LIRD model mimics RP pathogenesis in some aspects, these results suggest a causative link between retinal degeneration and VH inflammation in RP progression, and the increased CCL2 level in VH may reflect similar elevated CCL2 expression in the degenerative retina.PMID:38222454 | PMC:PMC10784230 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Wei Liu Xingfei Zhu Xiangyu Ge Yulin Chen David Wan-Cheng Li Lili Gong Source Type: research
The apoptotic and anti-proliferative effect of Lysyl oxidase propeptide in Y79 human retinoblastoma cells
CONCLUSIONS: Our results demonstrate the anti-tumorigenic effect of LOX-PP in Y79 RB cells by inducing apoptosis and decreasing proliferation. This effect was mediated by the downregulation of AKT signaling. These results suggest that LOX-PP can be explored as a therapeutic molecule in RB.PMID:38222455 | PMC:PMC10784223 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Nareshkumar Ragavachetty Nagaraj Sulochana Konerirajapuram Natarajan Coral Karunakaran Source Type: research
Identification and phenotypic analysis of novel LTBP2 mutations in a Chinese cohort with congenital ectopia lentis
CONCLUSION: This study reported the mutation frequency of the LTBP2 gene in a Chinese CEL cohort and provided novel insight into LTBP2-related genotype-phenotype associations in CEL.PMID:38222456 | PMC:PMC10784221 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Liyan Liu Dongwei Guo Fengmei Yang Haotian Qi Yijing Zhou Danying Zheng Guangming Jin Source Type: research
Timolol maleate, a β blocker eye drop, improved edema in a retinal vein occlusion model
CONCLUSIONS: These results indicate that timolol eye drops may be a potential option for RVO treatment.PMID:38222457 | PMC:PMC10784217 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Shinichiro Fuma Yae Hidaka Anri Nishinaka Hiroto Yasuda Kota Aoshima Shinsuke Nakamura Hideaki Hara Masamitsu Shimazawa Source Type: research
Protein modeling and in silico analysis to assess pathogenicity of < em > ABCA4 < /em > variants in patients with inherited retinal disease
CONCLUSIONS: In this report, we describe a systematic approach to predicting the pathogenicity of ABCA4 variants by means of three-dimensional (3D) protein modeling and in silico structure analysis. Our results demonstrate concordance between disease severity and structural changes in protein models induced by genetic variations. Furthermore, the present study suggests that in silico protein structure analysis can be used as a predictor of pathogenicity and may facilitate the assessment of genetic VUS.PMID:38222458 | PMC:PMC10784225 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Senem Cevik Nutsuchar Wangtiraumnuay Kristof Van Schelvergem Mai Tsukikawa Jenina Capasso Subhasis B Biswas Barry Bodt Alex V Levin Esther Biswas-Fiss Source Type: research
Collagen crosslinking impacts stromal wound healing and haze formation in a rabbit phototherapeutic keratectomy model
CONCLUSIONS: We showed that stromal haze formation and stromal stiffness is significantly increased following CXL, regardless of whether it is performed at or before the time of PTK. Further knowledge of the biophysical cues involved in determining corneal wound healing duration and outcomes will be important for understanding scarring following CXL and for the development of improved therapeutic options.PMID:37859806 | PMC:PMC10584030 (Source: Molecular Vision)
Source: Molecular Vision - October 20, 2023 Category: Molecular Biology Authors: Bret A Moore Iman Jalilian Soohyun Kim Makiko Mizutani Madison Mukai Connor Chang Alec M Entringer Kamesh Dhamodaran Vijay Krishna Raghunathan Leandro B C Teixeira Christopher J Murphy Sara M Thomasy Source Type: research
PET imaging of retinal inflammation in mice exposed to blue light using [ < sup > 18 < /sup > F]-DPA-714
CONCLUSIONS: [18F]-DPA-714 micro-PET imaging might be a good method for evaluating early inflammatory status during retinal pathology.PMID:37859807 | PMC:PMC10584029 (Source: Molecular Vision)
Source: Molecular Vision - October 20, 2023 Category: Molecular Biology Authors: Yuan Chen Yixiang Zhou Xue Zhu Ge Yan Donghui Pan Lizhen Wang Min Yang Ke Wang Source Type: research
The impact of early RPE cell junction loss on VEGF, Ang-2, and TIMP secretion in vitro
CONCLUSIONS: These results suggest a correlation between loss of junctions, abnormal angiogenic protein secretion, and reduced OS phagocytosis. Furthermore, Ang-2 and TIMP-1 proteins might be beneficial targets for AMD treatments, and their roles in retinal diseases deserve further investigation.PMID:37859808 | PMC:PMC10584031 (Source: Molecular Vision)
Source: Molecular Vision - October 20, 2023 Category: Molecular Biology Authors: Chase Paterson Jamen Cannon Elizabeth Vargis Source Type: research
Collagen crosslinking impacts stromal wound healing and haze formation in a rabbit phototherapeutic keratectomy model
CONCLUSIONS: We showed that stromal haze formation and stromal stiffness is significantly increased following CXL, regardless of whether it is performed at or before the time of PTK. Further knowledge of the biophysical cues involved in determining corneal wound healing duration and outcomes will be important for understanding scarring following CXL and for the development of improved therapeutic options.PMID:37859806 | PMC:PMC10584030 (Source: Molecular Vision)
Source: Molecular Vision - October 20, 2023 Category: Molecular Biology Authors: Bret A Moore Iman Jalilian Soohyun Kim Makiko Mizutani Madison Mukai Connor Chang Alec M Entringer Kamesh Dhamodaran Vijay Krishna Raghunathan Leandro B C Teixeira Christopher J Murphy Sara M Thomasy Source Type: research
PET imaging of retinal inflammation in mice exposed to blue light using [ < sup > 18 < /sup > F]-DPA-714
CONCLUSIONS: [18F]-DPA-714 micro-PET imaging might be a good method for evaluating early inflammatory status during retinal pathology.PMID:37859807 | PMC:PMC10584029 (Source: Molecular Vision)
Source: Molecular Vision - October 20, 2023 Category: Molecular Biology Authors: Yuan Chen Yixiang Zhou Xue Zhu Ge Yan Donghui Pan Lizhen Wang Min Yang Ke Wang Source Type: research
The impact of early RPE cell junction loss on VEGF, Ang-2, and TIMP secretion in vitro
CONCLUSIONS: These results suggest a correlation between loss of junctions, abnormal angiogenic protein secretion, and reduced OS phagocytosis. Furthermore, Ang-2 and TIMP-1 proteins might be beneficial targets for AMD treatments, and their roles in retinal diseases deserve further investigation.PMID:37859808 | PMC:PMC10584031 (Source: Molecular Vision)
Source: Molecular Vision - October 20, 2023 Category: Molecular Biology Authors: Chase Paterson Jamen Cannon Elizabeth Vargis Source Type: research
Collagen crosslinking impacts stromal wound healing and haze formation in a rabbit phototherapeutic keratectomy model
CONCLUSIONS: We showed that stromal haze formation and stromal stiffness is significantly increased following CXL, regardless of whether it is performed at or before the time of PTK. Further knowledge of the biophysical cues involved in determining corneal wound healing duration and outcomes will be important for understanding scarring following CXL and for the development of improved therapeutic options.PMID:37859806 | PMC:PMC10584030 (Source: Molecular Vision)
Source: Molecular Vision - October 20, 2023 Category: Molecular Biology Authors: Bret A Moore Iman Jalilian Soohyun Kim Makiko Mizutani Madison Mukai Connor Chang Alec M Entringer Kamesh Dhamodaran Vijay Krishna Raghunathan Leandro B C Teixeira Christopher J Murphy Sara M Thomasy Source Type: research
