HLA Correlations with Clinical Phenotypes and Risk of Metabolic Comorbidities in Singapore Chinese Psoriasis Patients
ConclusionOur results demonstrate the growing importance of discerning population-specific clinical phenotypes and their association with certain HLA alleles in psoriasis. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - August 30, 2019 Category: Molecular Biology Source Type: research
Loop Mediated Isothermal Amplification: A Promising Tool for Screening Genetic Mutations
AbstractMutation screening is elemental for clinical diagnosis and in determining therapeutic strategies. Nucleic acid-based techniques are considered to be the most accurate tools in genetic diagnosis. One such technique is loop-mediated isothermal amplification (LAMP) assay, which has seen tremendous applications in recent years. The advantages of the assay lie in its rapidity, efficiency, sensitivity, and cost. It works in isothermal conditions and amplifies the target gene using DNA polymerases that have strand displacement activity. To date, the assay has been widely used in different fields of research, including pat...
Source: Molecular Diagnosis and Therapy - August 7, 2019 Category: Molecular Biology Source Type: research
Prognostic Significance of FOXC1 in Various Cancers: A Systematic Review and Meta-Analysis
ConclusionIn summary, FOXC1 protein expression indicated poor survival outcome in various carcinomas, especially in patients with breast cancer, suggesting it as a possible biomarker for the prognosis in multiple carcinomas. Further clinical evaluation and large-scale cohort studies are required to accurately identify its possible clinical utility. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - July 31, 2019 Category: Molecular Biology Source Type: research
Clinical Implications of Chromosomal Instability (CIN) and Kinetochore Abnormalities in Breast Cancers
AbstractGenetic instability is a defining property of cancer cells and is the basis of various lesions including point mutations, copy number alterations and translocations. Chromosomal instability (CIN) is part of the genetic instability of cancer and consists of copy number alterations in whole or parts of cancer cell chromosomes. CIN is observed in differing degrees in most cancers. In breast cancer, CIN is commonly part of the genomic landscape of the disease and has a higher incidence in aggressive sub-types. Tumor suppressors that are commonly mutated or disabled in cancer, such as p53 and pRB, play roles in protecti...
Source: Molecular Diagnosis and Therapy - July 31, 2019 Category: Molecular Biology Source Type: research
Salivary Total Protease Activity Based on a Broad-Spectrum Fluorescence Resonance Energy Transfer Approach to Monitor Induction and Resolution of Gingival Inflammation
ConclusionThe results indicate that differential inflammatory responses encompass inherent variations in total salivary proteolytic activities, which could be further utilised in contemporary diagnostic, prognostic and treatment modalities for periodontal diseases. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - July 31, 2019 Category: Molecular Biology Source Type: research
