Unraveling Emerging Anal Cancer Clinical Biomarkers from Current Immuno-Oncogenomics Advances
AbstractAnal squamous cell carcinoma (ASCC) is a rare gastrointestinal malignancy associated with high-risk human papillomavirus (HPV) and is currently one of the fastest-growing causes of cancer incidence and mortality in developed countries. Although next-generation sequencing technologies (NGS) have revolutionized cancer and immuno-genomic research in various tumor types, a limited amount of clinical research has been developed to investigate the expression and the functional characterization of genomic data in ASCC. Herein, we comprehensively assess recent advancements in “omics” research, including a systematic an...
Source: Molecular Diagnosis and Therapy - January 24, 2024 Category: Molecular Biology Source Type: research
The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance
AbstractThe complement system plays a dual role in the body, either as a first-line defense barrier when balanced between activation and inhibition or as a potential driver of complement-associated injury or diseases when unbalanced or over-activated. C4b-binding protein (C4BP) was the first circulating complement regulatory protein identified and it functions as an important complement inhibitor. C4BP can suppress the over-activation of complement components and prevent the complement system from attacking the host cells through the binding of complement cleavage products C4b and C3b, working in concert as a cofactor fo...
Source: Molecular Diagnosis and Therapy - January 23, 2024 Category: Molecular Biology Source Type: research
Exagamglogene Autotemcel: First Approval
This article summarizes the milestones in the development of exagamglogene autotemcel leading to these first approvals. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - January 17, 2024 Category: Molecular Biology Source Type: research
Acknowledgement to Referees
(Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - January 3, 2024 Category: Molecular Biology Source Type: research
Personalizing Oncolytic Immunovirotherapy Approaches
AbstractDevelopment of successful cancer therapeutics requires exploration of the differences in genetics, metabolism, and interactions with the immune system among malignant and normal cells. The clinical observation of spontaneous tumor regression following natural infection with microorganism has created the premise of their use as cancer therapeutics. Oncolytic viruses (OVs) originate from viruses with attenuated virulence in humans, well-characterized vaccine strains of known human pathogens, or engineered replication-deficient viral vectors. Their selectivity is based on receptor ex pression level and post entry r...
Source: Molecular Diagnosis and Therapy - December 27, 2023 Category: Molecular Biology Source Type: research
Acute Fluid Biomarkers for Diagnosis and Prognosis in Children with Mild Traumatic Brain Injury: A Systematic Review
ConclusionsThe largest amount of evidence supported the potential use of S100B, glial fibrillary acidic protein, and UCH-L1, but there was mixed accuracy for diagnosis and prognostication for all biomarkers in pediatric mTBI. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - December 22, 2023 Category: Molecular Biology Source Type: research
Viral Vector-Based Gene Therapy for Epilepsy: What Does the Future Hold?
AbstractIn recent years, many pre-clinical studies have tested gene therapy approaches as possible treatments for epilepsy, following the idea that they may provide an alternative to conventional pharmacological and surgical options. Multiple gene therapy approaches have been developed, including those based on anti-sense oligonucleotides, RNA interference, and viral vectors. In this opinion article, we focus on translational issues related to viral vector-mediated gene therapy for epilepsy. Research has advanced dramatically in addressing issues like viral vector optimization, target identification, strategies of gene exp...
Source: Molecular Diagnosis and Therapy - December 16, 2023 Category: Molecular Biology Source Type: research
Development of a Novel Internally Controlled HrpB1 Gene-Based Real-Time qPCR Assay for Detection of Burkholderia pseudomallei
ConclusionThe results of the study showed the applicability of a novel HrpB1-based qPCR assay for sensitive and specific detection of B. pseudomallei in diverse clinical and environmental samples. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - December 12, 2023 Category: Molecular Biology Source Type: research
Comment on: “Steps to Improve Precision Medicine in Epilepsy”: Are we all Agreed on the Definition?
(Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - December 9, 2023 Category: Molecular Biology Source Type: research
Genotype and Phenotype of Renal Hypouricemia: A Single-Center Study from China
ConclusionThe current study reported six novel variants inSLC22A12 andSLC2A9 genes of Chinese patients with RHUC. The variant c.944G>A (p.W315X) inSLC2A9 may be common in Chinese patients. EIAKI is the main clinical phenotype associated with RHUC in our cohort, with a favorable outcome. Hypercalciuria presented in some RHUC patients is a new finding. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - November 16, 2023 Category: Molecular Biology Source Type: research
Saliva Collection Methods Among Children and Adolescents: A Scoping Review
ConclusionOverall, saliva collection is well tolerated by children and adolescents, with the absorption and suction methods being preferred with young and uncooperative children. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - November 10, 2023 Category: Molecular Biology Source Type: research
Expanded Alternatives of CRISPR –Cas9 Applications in Immunotherapy of Colorectal Cancer
AbstractImmunotherapy for colorectal cancer (CRC) is limited to patients with advanced disease who have already undergone first-line chemotherapy and whose tumors exhibit microsatellite instability. Novel technical strategies are required to enhance therapeutic options and achieve a more robust immunological response. Therefore, exploring gene analysis and manipulation at the molecular level can further accelerate the development of advanced technologies to address these challenges. The emergence of advanced genome editing technology, particularly of clustered, regularly interspaced short palindromic repeats (CRISPR) –CR...
Source: Molecular Diagnosis and Therapy - October 31, 2023 Category: Molecular Biology Source Type: research
Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases
AbstractMicroRNAs (miRNAs) are endogenous noncoding RNAs that mediate the fibrotic process by regulating multiple targets. MicroRNA-based therapy can restore or inhibit miRNA expression and is expected to become an effective approach to prevent and alleviate fibrotic diseases. However, the safe, targeted, and effective delivery of miRNAs is a major challenge in translating miRNA therapy from bench to bedside. In this review, we briefly describe the pathophysiological process of fibrosis and the mechanism by which miRNAs regulate the progression of fibrosis. Additionally, we summarize the miRNA nanodelivery tools for fibrot...
Source: Molecular Diagnosis and Therapy - October 28, 2023 Category: Molecular Biology Source Type: research
Correction: Recent Advancements in Nanomaterials: A Promising Way to Manage Neurodegenerative Disorders
(Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - October 26, 2023 Category: Molecular Biology Source Type: research
How Do Molecular Classifications Affect the Neoadjuvant Treatment of Muscle-Invasive Urothelial Carcinoma?
AbstractDespite the significant improvements in the field of oncological treatments in recent decades, and the advent of targeted therapies and immunotherapy, urothelial carcinoma of the bladder remains a highly heterogeneous and difficult-to-treat neoplasm with a poor prognosis. In this context, owing to the new methods of genomic sequencing, numerous studies have analyzed the genetic features of muscle-invasive bladder cancer, providing a consensus set of molecular classes, to identify malignancies that may respond better to specific treatments (standard chemotherapy, immunotherapy, target therapy, local-regional treatme...
Source: Molecular Diagnosis and Therapy - October 24, 2023 Category: Molecular Biology Source Type: research
