Identification of Familial Infections Using Multilocus Microsatellite Typing in Tinea Corporis due to Microsporum canis
We report three cases of tinea corporis due to M. canis from a single household with a domestic cat as a pet. The cases included a woman in her thirties (mother), a girl in her teens (older sister), and a girl in her teens (younger sister). Following sudden hair loss in the domestic cat, annular erythema with pruritus and scales appeared on the face, neck, and limbs of the older sister, younger sister, and mother, sequentially; they subsequently visited our hospital. Potassium hydroxide direct microscopy revealed filamentous fungi on all three women. In addition, short-haired colonies with a white to yellowish-white color ...
Source: Medical Mycology Journal - February 28, 2024 Category: Biology Authors: Chiaki Takahashi Ryohei Asakura Ayaka Chaya Michi Ota Kazutoshi Harada Tatsuya Inukai Shigeki Nakamura Yasuki Hata Emiko Watanabe-Okada Source Type: research
Most Azole-Susceptible Isolates of Aspergillus fumigatus in Hokkaido, Japan are Clustered with Worldwide Strains That Do Not Have Tandem Repeats in Cyp51A Promoter
In this study, we analyzed Aspergillus fumigatus short tandem repeat patterns of 106 strains isolated from the outdoor air, clinical specimens, and king penguins (Aptenodytes patagonicus) with aspergillosis in Japan, and compared them with those of 668 strains from AfumID (including six isolates from Japan). The results showed that the isolates were classified into three major groups. Group II contained most of the azole-resistant strains with 34- and 46-bp tandem repeats in cyp51A promoter. As in our previous study, OKH50 and Env1 strains were classified in Group II. Most of the azole-susceptible strains obtained in Japan...
Source: Medical Mycology Journal - February 28, 2024 Category: Biology Authors: Takuya Fujiwara Megumi Itoh Naoya Matsumoto Yusuke Koshizaki Syunpei Saitou Kazutaka Yamada Takahito Toyotome Source Type: research
Skin Manifestations of Micafungin Breakthrough Disseminated Trichosporonosis in Acute Megakaryoblastic Leukemia
Med Mycol J. 2024;65(1):17-21. doi: 10.3314/mmj.23-00009.ABSTRACTDisseminated trichosporonosis is a rare fungal infection whose risk factors are hematological malignancies and neutropenia. Recently, breakthrough Trichosporon infections after administration of micafungin, the first-line systemic antifungal agent in compromised hosts, have been widely recognized. A man in his seventies about 1 month into chemotherapy for acute megakaryoblastic leukemia presented with a worsening fever and dyspnea. The patient was being administered with empirical micafungin therapy for suspected candidiasis. As the symptoms progressed, scatt...
Source: Medical Mycology Journal - February 28, 2024 Category: Biology Authors: Yukiro Matsumoto Sayuka Arakawa Ken Sadahira Tomotaka Sato Kazuto Yamazaki Shuhei Nishimoto Source Type: research
A Case of Tinea Faciei due to Trichophyton indotineae with Steroid Rosacea Related to Topical Over-The-Counter Drugs Purchased Outside of Japan
Med Mycol J. 2024;65(1):23-26. doi: 10.3314/mmj.23-00014.ABSTRACTA Filipino woman in her forties had facial erythema that was being self-treated with over-the-counter (OTC) drugs purchased outside of Japan. The drugs included clobetasol propionate, antibiotic, and antifungal components. Her facial erythema symptoms were worse during summertime. KOH direct examination of annular erythema was positive for fungal hyphae and negative for Demodex folliculorum. Fungal culture revealed Trichophyton indotineae based on internal transcribed spacer sequence analysis. Minimal inhibitory concentration for terbinafine was 0.06 µg/mL. ...
Source: Medical Mycology Journal - February 28, 2024 Category: Biology Authors: Norihito Fukada Hisashi Kobayashi Manabu Nakazono Keita Ohyachi Akinori Takeda Takashi Yaguchi Miyuki Okada Tomotaka Sato Source Type: research
A Silkworm Infection Model for Evaluating In Vivo Biofilm Formation by Pathogenic Fungi
Med Mycol J. 2024;65(1):7-12. doi: 10.3314/mmj.24.001.ABSTRACTExperimental animal models are necessary for research on infectious diseases. Generally, mammalian animals, such as mice, are used for infection experiments. However, there are ethical issues associated with conducting infection experiments in mammals. This has made it difficult to perform infection experiments with a large number of individuals. The invertebrate silkworm, Bombyx mori, is gaining attention as a model animal for infection experiments, and silkworm infection models with various pathogens have been established. This review provides information on t...
Source: Medical Mycology Journal - February 28, 2024 Category: Biology Authors: Yasuhiko Matsumoto Shintaro Eshima Sanae Kurakado Takashi Sugita Source Type: research
In vitro Azole Susceptibility Testing of Japanese Isolates of Itraconazole-Resistant Dermatophytes
Med Mycol J. 2023;64(4):103-105. doi: 10.3314/mmj.23-00005.ABSTRACTWe conducted antifungal susceptibility testing on itraconazole (ITCZ)-resistant isolates of Trichophyton interdigitale and Trichophyton rubrum collected from Japanese patients in 2021 and 2022. The aim of the present study was to determine the most effective drug against ITCZ-resistant strains of dermatophytes. In all isolates, the minimum inhibitory concentrations (MICs) were > 32 mg/l for ITCZ, < 0.03 to 0.5 mg/l for ravuconazole (RVCZ), and < 0.03 mg/l for efinaconazole (EFCZ), luliconazole (LUCZ), and terbinafine (TRBF). Thus, in tinea unguium ...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Honoka Nojo Junichiro Hiruma Hiromitsu Noguchi Masataro Hiruma Kazutoshi Harada Koichi Makimura Rui Kano Source Type: research
Invasive Malassezia Infections
Med Mycol J. 2023;64(4):79-83. doi: 10.3314/mmj.23-003.ABSTRACTThe Malassezia species are dimorphic fungi that require lipids such as olive oil for their growth. They are constituents of the normal human skin microbiota and can affix to the host or other surfaces through the establishment of biofilms. Malassezia species are accountable for superficial mycoses like folliculitis. Additionally, they are capable of causing invasive infections, such as of the bloodstream, in neonates and immunocompromised patients, albeit infrequently. Catheter-associated bloodstream infections in neonates are the most commonly reported invasiv...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Masato Tashiro Takahiro Takazono Koichi Izumikawa Source Type: research
2021 Epidemiological Survey of Dermatomycoses in Japan
Med Mycol J. 2023;64(4):85-94. doi: 10.3314/mmj.23-00008.ABSTRACTThis is a report of the results of the epidemiological survey on dermatomycoses conducted in 2021. A total of 9,442 patients with dermatomycosis were reported for one year. They include 8,151 (86.3%) with dermatophytosis, 796 (8.4%) with candidiasis, 484 (5.1%) with Malassezia infection, and 11 (0.1%) with deep cutaneous mycosis. In order, the most common types of dermatophytoses were tinea pedis (4,195 cases, 2,341 males and 1,854 females), tinea unguium (2,711 cases, 1,509 males and 1,202 females), tinea corporis (674 cases, 445 males and 229 females), tine...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Kaori Nakamura Tomoo Fukuda Source Type: research
Importance of Accurate Identification and Antifungal Susceptibility Testing of Aspergillus Species in Clinical Settings
In conclusion, accurate identification of Aspergillus spp. and ASTs are needed to carry out appropriate treatment. Moreover, we hope that these microbiological tests will be widely used in clinical laboratories to improve clinical practice.PMID:38030277 | DOI:10.3314/mmj.23-004 (Source: Medical Mycology Journal)
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Keita Takeda Junko Suzuki Yuka Sasaki Akira Watanabe Katsuhiko Kamei Source Type: research
Isolation of Aspergillus udagawae in Canaliculitis: A Case Report
Med Mycol J. 2023;64(4):99-102. doi: 10.3314/mmj.23-00004.ABSTRACTAspergillus udagawae is a cryptic species of Aspergillus section Fumigati. Here, we report a case of canaliculitis with isolated A. udagawae. Fungal canaliculitis is a rare lacrimal disease, and its clinical features are poorly understood. The causative fungus was initially misclassified as Aspergillus thermomutatus by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) but was finally identified as A. udagawae by β-tubulin genetic analysis. The patient showed rapid improvement and did not experience relapse after dra...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Yuji Nishihara Takahito Nakamura Yuki Sakai Yumiko Ban Masato Tashiro Koichi Izumikawa Kei Kasahara Source Type: research
In vitro Azole Susceptibility Testing of Japanese Isolates of Itraconazole-Resistant Dermatophytes
Med Mycol J. 2023;64(4):103-105. doi: 10.3314/mmj.23-00005.ABSTRACTWe conducted antifungal susceptibility testing on itraconazole (ITCZ)-resistant isolates of Trichophyton interdigitale and Trichophyton rubrum collected from Japanese patients in 2021 and 2022. The aim of the present study was to determine the most effective drug against ITCZ-resistant strains of dermatophytes. In all isolates, the minimum inhibitory concentrations (MICs) were > 32 mg/l for ITCZ, < 0.03 to 0.5 mg/l for ravuconazole (RVCZ), and < 0.03 mg/l for efinaconazole (EFCZ), luliconazole (LUCZ), and terbinafine (TRBF). Thus, in tinea unguium ...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Honoka Nojo Junichiro Hiruma Hiromitsu Noguchi Masataro Hiruma Kazutoshi Harada Koichi Makimura Rui Kano Source Type: research
Invasive Malassezia Infections
Med Mycol J. 2023;64(4):79-83. doi: 10.3314/mmj.23-003.ABSTRACTThe Malassezia species are dimorphic fungi that require lipids such as olive oil for their growth. They are constituents of the normal human skin microbiota and can affix to the host or other surfaces through the establishment of biofilms. Malassezia species are accountable for superficial mycoses like folliculitis. Additionally, they are capable of causing invasive infections, such as of the bloodstream, in neonates and immunocompromised patients, albeit infrequently. Catheter-associated bloodstream infections in neonates are the most commonly reported invasiv...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Masato Tashiro Takahiro Takazono Koichi Izumikawa Source Type: research
2021 Epidemiological Survey of Dermatomycoses in Japan
Med Mycol J. 2023;64(4):85-94. doi: 10.3314/mmj.23-00008.ABSTRACTThis is a report of the results of the epidemiological survey on dermatomycoses conducted in 2021. A total of 9,442 patients with dermatomycosis were reported for one year. They include 8,151 (86.3%) with dermatophytosis, 796 (8.4%) with candidiasis, 484 (5.1%) with Malassezia infection, and 11 (0.1%) with deep cutaneous mycosis. In order, the most common types of dermatophytoses were tinea pedis (4,195 cases, 2,341 males and 1,854 females), tinea unguium (2,711 cases, 1,509 males and 1,202 females), tinea corporis (674 cases, 445 males and 229 females), tine...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Kaori Nakamura Tomoo Fukuda Source Type: research
Importance of Accurate Identification and Antifungal Susceptibility Testing of Aspergillus Species in Clinical Settings
In conclusion, accurate identification of Aspergillus spp. and ASTs are needed to carry out appropriate treatment. Moreover, we hope that these microbiological tests will be widely used in clinical laboratories to improve clinical practice.PMID:38030277 | DOI:10.3314/mmj.23-004 (Source: Medical Mycology Journal)
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Keita Takeda Junko Suzuki Yuka Sasaki Akira Watanabe Katsuhiko Kamei Source Type: research
Isolation of Aspergillus udagawae in Canaliculitis: A Case Report
Med Mycol J. 2023;64(4):99-102. doi: 10.3314/mmj.23-00004.ABSTRACTAspergillus udagawae is a cryptic species of Aspergillus section Fumigati. Here, we report a case of canaliculitis with isolated A. udagawae. Fungal canaliculitis is a rare lacrimal disease, and its clinical features are poorly understood. The causative fungus was initially misclassified as Aspergillus thermomutatus by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) but was finally identified as A. udagawae by β-tubulin genetic analysis. The patient showed rapid improvement and did not experience relapse after dra...
Source: Medical Mycology Journal - November 29, 2023 Category: Biology Authors: Yuji Nishihara Takahito Nakamura Yuki Sakai Yumiko Ban Masato Tashiro Koichi Izumikawa Kei Kasahara Source Type: research
